Cannabinoid Receptors Overexpression in a Rat Model of Irritable Bowel Syndrome (IBS) after Treatment with a Ketogenic Diet

• Published in: International journal of molecular sciences Vol. 22; no. 6; p. 2880
• Main Authors: Gigante, Isabella, Tutino, Valeria, Russo, Francesco, De Nunzio, Valentina, Coletta, Sergio, Armentano, Raffaele, Crovace, Alberto, Caruso, Maria Gabriella, Orlando, Antonella, Notarnicola, Maria
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 12.03.2021; MDPI
• Subjects: Animals; Cannabinoids - metabolism; Carbohydrates; Diet; Diet, Ketogenic - adverse effects; Disease Models, Animal; Endocannabinoids - genetics; Gene expression; Glucose; Humans; Inflammation; Intestinal Mucosa - drug effects; Intestinal Mucosa - metabolism; Irritable bowel syndrome; Irritable Bowel Syndrome - diet therapy; Irritable Bowel Syndrome - genetics; Irritable Bowel Syndrome - pathology; Metabolism; Motility; Nervous system; Permeability; Protein expression; Proteins; Rats; Receptor, Cannabinoid, CB1 - genetics; Receptor, Cannabinoid, CB2 - genetics; Receptors, Cannabinoid - genetics; rat model; cannabinoid receptors; irritable bowel syndrome; ketogenic diet

The administration of a ketogenic diet (KD) has been considered therapeutic in subjects with irritable bowel syndrome (IBS). This study aimed to investigate the molecular mechanisms by which a low-carbohydrate diet, such as KD, can improve gastrointestinal symptoms and functions in an animal model o...