Cannabinoid Receptors Overexpression in a Rat Model of Irritable Bowel Syndrome (IBS) after Treatment with a Ketogenic Diet
The administration of a ketogenic diet (KD) has been considered therapeutic in subjects with irritable bowel syndrome (IBS). This study aimed to investigate the molecular mechanisms by which a low-carbohydrate diet, such as KD, can improve gastrointestinal symptoms and functions in an animal model o...
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| Published in | International journal of molecular sciences Vol. 22; no. 6; p. 2880 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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12.03.2021
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| Abstract | The administration of a ketogenic diet (KD) has been considered therapeutic in subjects with irritable bowel syndrome (IBS). This study aimed to investigate the molecular mechanisms by which a low-carbohydrate diet, such as KD, can improve gastrointestinal symptoms and functions in an animal model of IBS by evaluating possible changes in intestinal tissue expression of endocannabinoid receptors. In rats fed a KD, we detected a significant restoration of cell damage to the intestinal crypt base, a histological feature of IBS condition, and upregulation of CB1 and CB2 receptors. The diet also affected glucose metabolism and intestinal membrane permeability, with an overexpression of the glucose transporter GLUT1 and tight junction proteins in treated rats. The present data suggest that CB receptors represent one of the molecular pathways through which the KD works and support possible cannabinoid-mediated protection at the intestinal level in the IBS rats after dietary treatment. |
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| AbstractList | The administration of a ketogenic diet (KD) has been considered therapeutic in subjects with irritable bowel syndrome (IBS). This study aimed to investigate the molecular mechanisms by which a low-carbohydrate diet, such as KD, can improve gastrointestinal symptoms and functions in an animal model of IBS by evaluating possible changes in intestinal tissue expression of endocannabinoid receptors. In rats fed a KD, we detected a significant restoration of cell damage to the intestinal crypt base, a histological feature of IBS condition, and upregulation of CB1 and CB2 receptors. The diet also affected glucose metabolism and intestinal membrane permeability, with an overexpression of the glucose transporter GLUT1 and tight junction proteins in treated rats. The present data suggest that CB receptors represent one of the molecular pathways through which the KD works and support possible cannabinoid-mediated protection at the intestinal level in the IBS rats after dietary treatment. The administration of a ketogenic diet (KD) has been considered therapeutic in subjects with irritable bowel syndrome (IBS). This study aimed to investigate the molecular mechanisms by which a low-carbohydrate diet, such as KD, can improve gastrointestinal symptoms and functions in an animal model of IBS by evaluating possible changes in intestinal tissue expression of endocannabinoid receptors. In rats fed a KD, we detected a significant restoration of cell damage to the intestinal crypt base, a histological feature of IBS condition, and upregulation of CB1 and CB2 receptors. The diet also affected glucose metabolism and intestinal membrane permeability, with an overexpression of the glucose transporter GLUT1 and tight junction proteins in treated rats. The present data suggest that CB receptors represent one of the molecular pathways through which the KD works and support possible cannabinoid-mediated protection at the intestinal level in the IBS rats after dietary treatment.The administration of a ketogenic diet (KD) has been considered therapeutic in subjects with irritable bowel syndrome (IBS). This study aimed to investigate the molecular mechanisms by which a low-carbohydrate diet, such as KD, can improve gastrointestinal symptoms and functions in an animal model of IBS by evaluating possible changes in intestinal tissue expression of endocannabinoid receptors. In rats fed a KD, we detected a significant restoration of cell damage to the intestinal crypt base, a histological feature of IBS condition, and upregulation of CB1 and CB2 receptors. The diet also affected glucose metabolism and intestinal membrane permeability, with an overexpression of the glucose transporter GLUT1 and tight junction proteins in treated rats. The present data suggest that CB receptors represent one of the molecular pathways through which the KD works and support possible cannabinoid-mediated protection at the intestinal level in the IBS rats after dietary treatment. |
| Author | De Nunzio, Valentina Coletta, Sergio Russo, Francesco Tutino, Valeria Crovace, Alberto Caruso, Maria Gabriella Notarnicola, Maria Armentano, Raffaele Gigante, Isabella Orlando, Antonella |
| AuthorAffiliation | 4 Animal Facility, National Institute of Gastroenterology, “S. de Bellis” Research Hospital, 70013 Castellana Grotte (BA), Italy; alberto.crovace@irccsdebellis.it 5 Ambulatory of Clinical Nutrition, National Institute of Gastroenterology, “S. de Bellis” Research Hospital, 70013 Castellana Grotte (BA), Italy; gabriella.caruso@irccsdebellis.it 1 Laboratory of Nutritional Biochemistry, National Institute of Gastroenterology, “S. de Bellis” Research Hospital, 70013 Castellana Grotte (BA), Italy; isabella.gigante87@gmail.com (I.G.); valeria.tutino@irccsdebellis.it (V.T.); valentinadx@hotmail.it (V.D.N.) 2 Laboratory of Nutritional Pathophysiology, National Institute of Gastroenterology, “S. de Bellis” Research Hospital, 70013 Castellana Grotte (BA), Italy; francesco.russo@irccsdebellis.it (F.R.); antonella.orlando@irccsdebellis.it (A.O.) 3 Histopathology Unit, National Institute of Gastroenterology, “S. de Bellis” Research Hospital, 70013 Castellana Grotte (BA), Italy; sergiofalaut@hotmail.it ( |
| AuthorAffiliation_xml | – name: 1 Laboratory of Nutritional Biochemistry, National Institute of Gastroenterology, “S. de Bellis” Research Hospital, 70013 Castellana Grotte (BA), Italy; isabella.gigante87@gmail.com (I.G.); valeria.tutino@irccsdebellis.it (V.T.); valentinadx@hotmail.it (V.D.N.) – name: 3 Histopathology Unit, National Institute of Gastroenterology, “S. de Bellis” Research Hospital, 70013 Castellana Grotte (BA), Italy; sergiofalaut@hotmail.it (S.C.); raffaele.armentano@irccsdebellis.it (R.A.) – name: 2 Laboratory of Nutritional Pathophysiology, National Institute of Gastroenterology, “S. de Bellis” Research Hospital, 70013 Castellana Grotte (BA), Italy; francesco.russo@irccsdebellis.it (F.R.); antonella.orlando@irccsdebellis.it (A.O.) – name: 4 Animal Facility, National Institute of Gastroenterology, “S. de Bellis” Research Hospital, 70013 Castellana Grotte (BA), Italy; alberto.crovace@irccsdebellis.it – name: 5 Ambulatory of Clinical Nutrition, National Institute of Gastroenterology, “S. de Bellis” Research Hospital, 70013 Castellana Grotte (BA), Italy; gabriella.caruso@irccsdebellis.it |
| Author_xml | – sequence: 1 givenname: Isabella orcidid: 0000-0003-3712-4149 surname: Gigante fullname: Gigante, Isabella – sequence: 2 givenname: Valeria surname: Tutino fullname: Tutino, Valeria – sequence: 3 givenname: Francesco orcidid: 0000-0003-0538-6072 surname: Russo fullname: Russo, Francesco – sequence: 4 givenname: Valentina orcidid: 0000-0001-7912-9023 surname: De Nunzio fullname: De Nunzio, Valentina – sequence: 5 givenname: Sergio surname: Coletta fullname: Coletta, Sergio – sequence: 6 givenname: Raffaele surname: Armentano fullname: Armentano, Raffaele – sequence: 7 givenname: Alberto surname: Crovace fullname: Crovace, Alberto – sequence: 8 givenname: Maria Gabriella orcidid: 0000-0003-4518-6307 surname: Caruso fullname: Caruso, Maria Gabriella – sequence: 9 givenname: Antonella orcidid: 0000-0001-8255-4776 surname: Orlando fullname: Orlando, Antonella – sequence: 10 givenname: Maria orcidid: 0000-0003-2274-2198 surname: Notarnicola fullname: Notarnicola, Maria |
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| Cites_doi | 10.1021/acs.jmedchem.9b01237 10.1080/09687680110090456 10.1159/000494512 10.3748/wjg.v23.i18.3356 10.1111/nmo.13675 10.15403/jgld-265 10.1136/gutjnl-2014-307264 10.3390/jcm7010004 10.1152/ajpgi.00242.2016 10.1111/j.1365-2982.2012.01921.x 10.1038/s41598-018-25190-5 10.1002/iub.315 10.2174/138161206777947425 10.2337/db13-0264 10.1007/s00213-010-2010-9 10.1016/j.brainresrev.2008.09.002 10.3389/fnins.2020.00371 10.3390/nu11020373 10.1016/j.expneurol.2011.04.020 10.2337/db14-0721 10.3390/nu11071532 10.1016/j.mam.2012.07.001 10.1098/rstb.2011.0393 10.1111/j.1365-2982.2008.01175.x 10.1002/(SICI)1520-7560(199911/12)15:6<412::AID-DMRR72>3.0.CO;2-8 10.1016/j.biocel.2015.01.022 10.1016/j.neuint.2008.10.012 10.1038/nri912 10.3748/wjg.v22.i15.4009 10.1016/S0896-6273(03)00499-9 10.1111/jnc.12646 10.1093/ecco-jcc/jjaa253 10.1053/gast.2001.24044 10.1038/cdd.2016.142 10.3748/wjg.v23.i47.8321 10.1172/JCI200419465 10.2174/092986710790980023 10.3389/fphar.2012.00059 10.3390/nu12061652 10.1146/annurev-med-050218-013625 10.1002/jcb.26399 10.1111/j.1528-1167.2008.01765.x 10.1371/journal.pone.0115147 10.1111/jcmm.13359 10.1186/s13229-016-0099-3 10.1152/ajpgi.00294.2015 |
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| Keywords | rat model cannabinoid receptors irritable bowel syndrome ketogenic diet |
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| References | Daynes (ref_5) 2002; 2 Chen (ref_18) 2003; 39 Wang (ref_22) 2020; 63 Sartor (ref_28) 1997; 92 Chen (ref_45) 2017; 23 Drossman (ref_12) 2017; 13 Brugnatelli (ref_15) 2020; 14 ref_10 Hughes (ref_7) 2014; 129 Demizieux (ref_20) 2015; 64 Larauche (ref_26) 2012; 233 Camilleri (ref_49) 2012; 24 Aviello (ref_37) 2008; 12 Halmos (ref_13) 2015; 64 Nunn (ref_43) 2012; 367 Storr (ref_17) 2008; 20 ref_25 Wang (ref_31) 2001; 120 Vidali (ref_34) 2015; 63 Hansen (ref_19) 2009; 54 Mueckler (ref_23) 2013; 34 Pesce (ref_16) 2018; 22 Wu (ref_24) 2018; 119 Maalouf (ref_4) 2009; 59 ref_27 Newell (ref_52) 2016; 7 Howlett (ref_44) 2010; 17 Lipina (ref_35) 2013; 62 Massa (ref_38) 2004; 113 Kossoff (ref_1) 2009; 50 Austin (ref_14) 2009; 7 Hyland (ref_29) 2011; 214 Stafstrom (ref_30) 2012; 3 Maagaard (ref_51) 2016; 22 Fabisiak (ref_40) 2019; 28 Tuck (ref_33) 2019; 31 Ma (ref_9) 2018; 8 Augustin (ref_21) 2010; 62 ref_42 Laffel (ref_6) 1999; 15 Sacks (ref_3) 2018; 13 Pedersen (ref_50) 2017; 23 ref_2 Hinden (ref_46) 2019; 143 Wang (ref_32) 2017; 24 Lee (ref_36) 2016; 311 ref_8 Engel (ref_39) 2010; 61 Massi (ref_41) 2006; 12 Camilleri (ref_48) 2016; 311 Liu (ref_11) 2020; 71 Joost (ref_47) 2001; 18 |
| References_xml | – volume: 63 start-page: 3834 year: 2020 ident: ref_22 article-title: The Druggability of Solute Carriers publication-title: J. Med. Chem. doi: 10.1021/acs.jmedchem.9b01237 – volume: 92 start-page: 5S year: 1997 ident: ref_28 article-title: Pathogenesis and immune mechanisms of chronic inflammatory bowel diseases publication-title: Am. J. Gastroenterol. – volume: 18 start-page: 247 year: 2001 ident: ref_47 article-title: The extended GLUT-family of sugar/polyol transport facilitators: Nomenclature, sequence characteristics, and potential function of its novel members (review) publication-title: Mol. Membr. Biol. doi: 10.1080/09687680110090456 – volume: 143 start-page: 24 year: 2019 ident: ref_46 article-title: Do Endocannabinoids Regulate Glucose Reabsorption in the Kidney? publication-title: Nephron doi: 10.1159/000494512 – volume: 23 start-page: 3356 year: 2017 ident: ref_50 article-title: Low-FODMAP diet reduces irritable bowel symptoms in patients with inflammatory bowel disease publication-title: World J. Gastroenterol. doi: 10.3748/wjg.v23.i18.3356 – volume: 31 start-page: e13675 year: 2019 ident: ref_33 article-title: The impact of dietary fermentable carbohydrates on a postinflammatory model of irritable bowel syndrome publication-title: Neurogastroenterol. Motil. Off. J. Eur. Gastrointest. Motil. Soc. doi: 10.1111/nmo.13675 – volume: 13 start-page: 694 year: 2017 ident: ref_12 article-title: Improving the Treatment of Irritable Bowel Syndrome With the Rome IV Multidimensional Clinical Profile publication-title: Gastroenterol. Hepatol. – volume: 28 start-page: 473 year: 2019 ident: ref_40 article-title: Gastrointestinal Adverse Events of Cannabinoid 1 Receptor Inverse Agonists suggest their Potential Use in Irritable Bowel Syndrome with Constipation: A Systematic Review and Meta-Analysis publication-title: J. Gastrointest. Liver Dis. JGLD doi: 10.15403/jgld-265 – volume: 64 start-page: 93 year: 2015 ident: ref_13 article-title: Diets that differ in their FODMAP content alter the colonic luminal microenvironment publication-title: Gut doi: 10.1136/gutjnl-2014-307264 – ident: ref_27 doi: 10.3390/jcm7010004 – volume: 311 start-page: G777 year: 2016 ident: ref_48 article-title: Chemical and molecular factors in irritable bowel syndrome: Current knowledge, challenges, and unanswered questions publication-title: Am. J. Physiol. Gastrointest. Liver Physiol. doi: 10.1152/ajpgi.00242.2016 – volume: 24 start-page: 503 year: 2012 ident: ref_49 article-title: Intestinal barrier function in health and gastrointestinal disease publication-title: Neurogastroenterol. Motil. Off. J. Eur. Gastrointest. Motil. Soc. doi: 10.1111/j.1365-2982.2012.01921.x – volume: 8 start-page: 6670 year: 2018 ident: ref_9 article-title: Ketogenic diet enhances neurovascular function with altered gut microbiome in young healthy mice publication-title: Sci. Rep. doi: 10.1038/s41598-018-25190-5 – volume: 62 start-page: 315 year: 2010 ident: ref_21 article-title: The protein family of glucose transport facilitators: It’s not only about glucose after all publication-title: IUBMB life doi: 10.1002/iub.315 – volume: 12 start-page: 3135 year: 2006 ident: ref_41 article-title: Cannabinoids, immune system and cytokine network publication-title: Curr. Pharm. Des. doi: 10.2174/138161206777947425 – volume: 62 start-page: 3426 year: 2013 ident: ref_35 article-title: Mitochondrial substrate availability and its role in lipid-induced insulin resistance and proinflammatory signaling in skeletal muscle publication-title: Diabetes doi: 10.2337/db13-0264 – volume: 214 start-page: 71 year: 2011 ident: ref_29 article-title: Maternal separation as a model of brain-gut axis dysfunction publication-title: Psychopharmacology doi: 10.1007/s00213-010-2010-9 – volume: 13 start-page: 612 year: 2018 ident: ref_3 article-title: Multisociety Consensus Quality Improvement Revised Consensus Statement for Endovascular Therapy of Acute Ischemic Stroke publication-title: Int. J. Stroke Off. J. Int. Stroke Soc. – volume: 59 start-page: 293 year: 2009 ident: ref_4 article-title: The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies publication-title: Brain Res. Rev. doi: 10.1016/j.brainresrev.2008.09.002 – volume: 14 start-page: 371 year: 2020 ident: ref_15 article-title: Irritable Bowel Syndrome: Manipulating the Endocannabinoid System as First-Line Treatment publication-title: Front. Neurosci. doi: 10.3389/fnins.2020.00371 – ident: ref_2 doi: 10.3390/nu11020373 – volume: 233 start-page: 49 year: 2012 ident: ref_26 article-title: Stress and visceral pain: From animal models to clinical therapies publication-title: Exp. Neurol. doi: 10.1016/j.expneurol.2011.04.020 – volume: 64 start-page: 808 year: 2015 ident: ref_20 article-title: Acute activation of cannabinoid receptors by anandamide reduces gastrointestinal motility and improves postprandial glycemia in mice publication-title: Diabetes doi: 10.2337/db14-0721 – ident: ref_10 doi: 10.3390/nu11071532 – volume: 34 start-page: 121 year: 2013 ident: ref_23 article-title: The SLC2 (GLUT) family of membrane transporters publication-title: Mol. Asp. Med. doi: 10.1016/j.mam.2012.07.001 – volume: 367 start-page: 3342 year: 2012 ident: ref_43 article-title: Endocannabinoids in neuroendopsychology: Multiphasic control of mitochondrial function publication-title: Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci. doi: 10.1098/rstb.2011.0393 – volume: 20 start-page: 857 year: 2008 ident: ref_17 article-title: The role of the endocannabinoid system in the pathophysiology and treatment of irritable bowel syndrome publication-title: Neurogastroenterol. Motil. Off. J. Eur. Gastrointest. Motil. Soc. doi: 10.1111/j.1365-2982.2008.01175.x – volume: 15 start-page: 412 year: 1999 ident: ref_6 article-title: Ketone bodies: A review of physiology, pathophysiology and application of monitoring to diabetes publication-title: Diabetes/Metab. Res. Rev. doi: 10.1002/(SICI)1520-7560(199911/12)15:6<412::AID-DMRR72>3.0.CO;2-8 – volume: 63 start-page: 55 year: 2015 ident: ref_34 article-title: Mitochondria: The ketogenic diet--A metabolism-based therapy publication-title: Int. J. Biochem. Cell Biol. doi: 10.1016/j.biocel.2015.01.022 – volume: 54 start-page: 199 year: 2009 ident: ref_19 article-title: Ketogenic diet is antiepileptogenic in pentylenetetrazole kindled mice and decrease levels of N-acylethanolamines in hippocampus publication-title: Neurochem. Int. doi: 10.1016/j.neuint.2008.10.012 – volume: 2 start-page: 748 year: 2002 ident: ref_5 article-title: Emerging roles of PPARs in inflammation and immunity publication-title: Nat. Rev. Immunol. doi: 10.1038/nri912 – volume: 22 start-page: 4009 year: 2016 ident: ref_51 article-title: Follow-up of patients with functional bowel symptoms treated with a low FODMAP diet publication-title: World J. Gastroenterol. doi: 10.3748/wjg.v22.i15.4009 – volume: 39 start-page: 599 year: 2003 ident: ref_18 article-title: Long-term plasticity of endocannabinoid signaling induced by developmental febrile seizures publication-title: Neuron doi: 10.1016/S0896-6273(03)00499-9 – volume: 129 start-page: 426 year: 2014 ident: ref_7 article-title: The ketogenic diet component decanoic acid increases mitochondrial citrate synthase and complex I activity in neuronal cells publication-title: J. Neurochem. doi: 10.1111/jnc.12646 – ident: ref_42 doi: 10.1093/ecco-jcc/jjaa253 – volume: 120 start-page: 1381 year: 2001 ident: ref_31 article-title: Inhibition of the phosphatidylinositol 3-kinase pathway contributes to HT29 and Caco-2 intestinal cell differentiation publication-title: Gastroenterology doi: 10.1053/gast.2001.24044 – volume: 24 start-page: 458 year: 2017 ident: ref_32 article-title: Ketogenesis contributes to intestinal cell differentiation publication-title: Cell Death Differ. doi: 10.1038/cdd.2016.142 – volume: 23 start-page: 8321 year: 2017 ident: ref_45 article-title: Fructo-oligosaccharide intensifies visceral hypersensitivity and intestinal inflammation in a stress-induced irritable bowel syndrome mouse model publication-title: World J. Gastroenterol. doi: 10.3748/wjg.v23.i47.8321 – volume: 7 start-page: 706 year: 2009 ident: ref_14 article-title: A very low-carbohydrate diet improves symptoms and quality of life in diarrhea-predominant irritable bowel syndrome publication-title: Clin. Gastroenterol. Hepatol. Off. Clin. Pract. J. Am. Gastroenterol. Assoc. – volume: 113 start-page: 1202 year: 2004 ident: ref_38 article-title: The endogenous cannabinoid system protects against colonic inflammation publication-title: J. Clin. Investig. doi: 10.1172/JCI200419465 – volume: 17 start-page: 1382 year: 2010 ident: ref_44 article-title: CB(1) cannabinoid receptors and their associated proteins publication-title: Curr. Med. Chem. doi: 10.2174/092986710790980023 – volume: 3 start-page: 59 year: 2012 ident: ref_30 article-title: The ketogenic diet as a treatment paradigm for diverse neurological disorders publication-title: Front. Pharmacol. doi: 10.3389/fphar.2012.00059 – volume: 12 start-page: 81 year: 2008 ident: ref_37 article-title: Cannabinoids and gastrointestinal motility: Animal and human studies publication-title: Eur. Rev. Med Pharmacol. Sci. – ident: ref_25 doi: 10.3390/nu12061652 – volume: 71 start-page: 303 year: 2020 ident: ref_11 article-title: Low-FODMAP Diet for Irritable Bowel Syndrome: What We Know and What We Have Yet to Learn publication-title: Annu. Rev. Med. doi: 10.1146/annurev-med-050218-013625 – volume: 119 start-page: 2356 year: 2018 ident: ref_24 article-title: Effects of Glut1 gene silencing on proliferation, differentiation, and apoptosis of colorectal cancer cells by targeting the TGF-beta/PI3K-AKT-mTOR signaling pathway publication-title: J. Cell. Biochem. doi: 10.1002/jcb.26399 – volume: 50 start-page: 304 year: 2009 ident: ref_1 article-title: Optimal clinical management of children receiving the ketogenic diet: Recommendations of the International Ketogenic Diet Study Group publication-title: Epilepsia doi: 10.1111/j.1528-1167.2008.01765.x – ident: ref_8 doi: 10.1371/journal.pone.0115147 – volume: 22 start-page: 706 year: 2018 ident: ref_16 article-title: Endocannabinoid-related compounds in gastrointestinal diseases publication-title: J. Cell. Mol. Med. doi: 10.1111/jcmm.13359 – volume: 7 start-page: 37 year: 2016 ident: ref_52 article-title: Ketogenic diet modifies the gut microbiota in a murine model of autism spectrum disorder publication-title: Mol. Autism doi: 10.1186/s13229-016-0099-3 – volume: 61 start-page: 89 year: 2010 ident: ref_39 article-title: Mice lacking cannabinoid CB1-, CB2-receptors or both receptors show increased susceptibility to trinitrobenzene sulfonic acid (TNBS)-induced colitis publication-title: J. Physiol. Pharmacol. Off. J. Pol. Physiol. Soc. – volume: 311 start-page: G655 year: 2016 ident: ref_36 article-title: Endocannabinoids in the gastrointestinal tract publication-title: Am. J. Physiol. Gastrointest. Liver Physiol. doi: 10.1152/ajpgi.00294.2015 |
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| SubjectTerms | Animals Cannabinoids - metabolism Carbohydrates Diet Diet, Ketogenic - adverse effects Disease Models, Animal Endocannabinoids - genetics Gene expression Glucose Humans Inflammation Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Irritable bowel syndrome Irritable Bowel Syndrome - diet therapy Irritable Bowel Syndrome - genetics Irritable Bowel Syndrome - pathology Metabolism Motility Nervous system Permeability Protein expression Proteins Rats Receptor, Cannabinoid, CB1 - genetics Receptor, Cannabinoid, CB2 - genetics Receptors, Cannabinoid - genetics |
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| Title | Cannabinoid Receptors Overexpression in a Rat Model of Irritable Bowel Syndrome (IBS) after Treatment with a Ketogenic Diet |
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