Genetic Polymorphism of Drug Metabolising Enzymes in African Populations: Implications for the Use of Neuroleptics and Antidepressants

• Published in: Brain Research Bulletin Vol. 44; no. 5; pp. 561 - 571
• Main Authors: Masimirembwa, Collen M., Hasler, Julia A.
• Format: Book Review Journal Article
• Language: English
• Published: United States Elsevier Inc 1997
• Subjects: Africa; African Continental Ancestry Group - genetics; Alleles; Antidepressive Agents - pharmacokinetics; Antipsychotic Agents - pharmacokinetics; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6 - genetics; Cytochrome P-450 CYP2D6 - metabolism; Cytochrome P-450 Enzyme System - genetics; Cytochrome P-450 Enzyme System - metabolism; Cytochrome P450; Genetic Variation; Humans; Interindividual and interethnic variation; Mixed Function Oxygenases - genetics; Mixed Function Oxygenases - metabolism; Polymorphism, Genetic; Polymorphisms in Africa; Psychoactive drugs; Substrate Specificity; Polymorphisms in Africa; Interindividual and interethnic variation; Psychoactive drugs; Cytochrome P450

Metabolism of most drugs influences their pharmacological and toxicological effects. Drugs particularly affected are those with a narrow therapeutic window and that are subjected to considerable first-pass metabolism. Much of the interindividual and interethnic differences in effects of drugs is now...