Apelin is a novel angiogenic factor in retinal endothelial cells

• Published in: Biochemical and biophysical research communications Vol. 325; no. 2; pp. 395 - 400
• Main Authors: Kasai, Atsushi, Shintani, Norihito, Oda, Maki, Kakuda, Michiya, Hashimoto, Hitoshi, Matsuda, Toshio, Hinuma, Shuji, Baba, Akemichi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 10.12.2004
• Subjects: Adipokines; Angiogenesis; Angiogenesis Modulating Agents - metabolism; Angiogenesis Modulating Agents - pharmacology; Angiogenic Proteins - pharmacology; Angiogenic Proteins - physiology; Animals; Apelin; APJ; Capillaries - growth & development; Capillaries - ultrastructure; Carrier Proteins - pharmacology; Carrier Proteins - physiology; Cell Movement - drug effects; Cell Proliferation - drug effects; Endothelium; Endothelium, Vascular - cytology; Endothelium, Vascular - drug effects; Endothelium, Vascular - metabolism; Hemoglobins - analysis; Humans; Intercellular Signaling Peptides and Proteins; Mice; Neovascularization, Physiologic - drug effects; Orphan G-protein-coupled receptor; Recombinant Proteins - genetics; Recombinant Proteins - metabolism; Recombinant Proteins - pharmacology; Retina; Retina - cytology; Retina - drug effects; Retina - metabolism; RF/6A; Umbilical Veins - cytology; Vascular Endothelial Growth Factor A - pharmacology; VEGF; Angiogenesis; RF/6A; Orphan G-protein-coupled receptor; VEGF; Retina; APJ; Apelin; Endothelium

There has been much focus recently on the possible functions of apelin, an endogenous ligand for the orphan G-protein-coupled receptor APJ, in cardiovascular and central nervous systems. We report a new function of apelin as a novel angiogenic factor in retinal endothelial cells. The retinal endothe...