Apelin is a novel angiogenic factor in retinal endothelial cells

There has been much focus recently on the possible functions of apelin, an endogenous ligand for the orphan G-protein-coupled receptor APJ, in cardiovascular and central nervous systems. We report a new function of apelin as a novel angiogenic factor in retinal endothelial cells. The retinal endothe...

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Published in	Biochemical and biophysical research communications Vol. 325; no. 2; pp. 395 - 400
Main Authors	Kasai, Atsushi, Shintani, Norihito, Oda, Maki, Kakuda, Michiya, Hashimoto, Hitoshi, Matsuda, Toshio, Hinuma, Shuji, Baba, Akemichi
Format	Journal Article
Language	English
Published	United States Elsevier Inc 10.12.2004
Subjects	Adipokines Angiogenesis Angiogenesis Modulating Agents - metabolism Angiogenesis Modulating Agents - pharmacology Angiogenic Proteins - pharmacology Angiogenic Proteins - physiology Animals Apelin APJ Capillaries - growth & development Capillaries - ultrastructure Carrier Proteins - pharmacology Carrier Proteins - physiology Cell Movement - drug effects Cell Proliferation - drug effects Endothelium Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Hemoglobins - analysis Humans Intercellular Signaling Peptides and Proteins Mice Neovascularization, Physiologic - drug effects Orphan G-protein-coupled receptor Recombinant Proteins - genetics Recombinant Proteins - metabolism Recombinant Proteins - pharmacology Retina Retina - cytology Retina - drug effects Retina - metabolism RF/6A Umbilical Veins - cytology Vascular Endothelial Growth Factor A - pharmacology VEGF Angiogenesis RF/6A Orphan G-protein-coupled receptor VEGF Retina APJ Apelin Endothelium
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Abstract	There has been much focus recently on the possible functions of apelin, an endogenous ligand for the orphan G-protein-coupled receptor APJ, in cardiovascular and central nervous systems. We report a new function of apelin as a novel angiogenic factor in retinal endothelial cells. The retinal endothelial cell line RF/6A highly expressed both apelin and APJ transcripts, while human umbilical venous endothelial cells (HUVECs) only expressed apelin mRNA. In accordance with these observations, apelin at concentrations of 1 pM–1 μM significantly enhanced migration, proliferation, and capillary-like tube formation of RF/6A cells, but not those of HUVECs, whereas VEGF stimulates those parameters of both cell types. In vivo Matrigel plug assay for angiogenesis, the inclusion of 1 nM apelin in the Matrigel resulted in clear capillary-like formations with an increase of hemoglobin content in the plug. This is the first report showing that apelin is an angiogenic factor in retinal endothelial cells.
AbstractList	There has been much focus recently on the possible functions of apelin, an endogenous ligand for the orphan G-protein-coupled receptor APJ, in cardiovascular and central nervous systems. We report a new function of apelin as a novel angiogenic factor in retinal endothelial cells. The retinal endothelial cell line RF/6A highly expressed both apelin and APJ transcripts, while human umbilical venous endothelial cells (HUVECs) only expressed apelin mRNA. In accordance with these observations, apelin at concentrations of 1 pM-1 microM significantly enhanced migration, proliferation, and capillary-like tube formation of RF/6A cells, but not those of HUVECs, whereas VEGF stimulates those parameters of both cell types. In vivo Matrigel plug assay for angiogenesis, the inclusion of 1 nM apelin in the Matrigel resulted in clear capillary-like formations with an increase of hemoglobin content in the plug. This is the first report showing that apelin is an angiogenic factor in retinal endothelial cells. There has been much focus recently on the possible functions of apelin, an endogenous ligand for the orphan G-protein-coupled receptor APJ, in cardiovascular and central nervous systems. We report a new function of apelin as a novel angiogenic factor in retinal endothelial cells. The retinal endothelial cell line RF/6A highly expressed both apelin and APJ transcripts, while human umbilical venous endothelial cells (HUVECs) only expressed apelin mRNA. In accordance with these observations, apelin at concentrations of 1pM-1 mu M significantly enhanced migration, proliferation, and capillary-like tube formation of RF/6A cells, but not those of HUVECs, whereas VEGF stimulates those parameters of both cell types. In vivo Matrigel plug assay for angiogenesis, the inclusion of 1nM apelin in the Matrigel resulted in clear capillary-like formations with an increase of hemoglobin content in the plug. This is the first report showing that apelin is an angiogenic factor in retinal endothelial cells. There has been much focus recently on the possible functions of apelin, an endogenous ligand for the orphan G-protein-coupled receptor APJ, in cardiovascular and central nervous systems. We report a new function of apelin as a novel angiogenic factor in retinal endothelial cells. The retinal endothelial cell line RF/6A highly expressed both apelin and APJ transcripts, while human umbilical venous endothelial cells (HUVECs) only expressed apelin mRNA. In accordance with these observations, apelin at concentrations of 1 pM–1 μM significantly enhanced migration, proliferation, and capillary-like tube formation of RF/6A cells, but not those of HUVECs, whereas VEGF stimulates those parameters of both cell types. In vivo Matrigel plug assay for angiogenesis, the inclusion of 1 nM apelin in the Matrigel resulted in clear capillary-like formations with an increase of hemoglobin content in the plug. This is the first report showing that apelin is an angiogenic factor in retinal endothelial cells.
Author	Hashimoto, Hitoshi Baba, Akemichi Shintani, Norihito Matsuda, Toshio Kakuda, Michiya Kasai, Atsushi Oda, Maki Hinuma, Shuji
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BackLink	https://www.ncbi.nlm.nih.gov/pubmed/15530405$$D View this record in MEDLINE/PubMed
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SubjectTerms	Adipokines Angiogenesis Angiogenesis Modulating Agents - metabolism Angiogenesis Modulating Agents - pharmacology Angiogenic Proteins - pharmacology Angiogenic Proteins - physiology Animals Apelin APJ Capillaries - growth & development Capillaries - ultrastructure Carrier Proteins - pharmacology Carrier Proteins - physiology Cell Movement - drug effects Cell Proliferation - drug effects Endothelium Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Hemoglobins - analysis Humans Intercellular Signaling Peptides and Proteins Mice Neovascularization, Physiologic - drug effects Orphan G-protein-coupled receptor Recombinant Proteins - genetics Recombinant Proteins - metabolism Recombinant Proteins - pharmacology Retina Retina - cytology Retina - drug effects Retina - metabolism RF/6A Umbilical Veins - cytology Vascular Endothelial Growth Factor A - pharmacology VEGF
Title	Apelin is a novel angiogenic factor in retinal endothelial cells
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