Prevalence of Antimicrobial Resistance in Eighty Clinical Isolates of Helicobacter pylori

We studied the in vitro susceptibility of 80 Helicobacter pylori clinical isolates to several antimicrobials commonly used to treat the infection, using the Epsilometer test (E-test). We also compared E-test and disk diffusion test in determining H. pylori susceptibility to the same antibiotics. We...

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Published inChemotherapy (Basel) Vol. 45; no. 1; pp. 8 - 14
Main Authors Iovene, M.R., Romano, M., Pilloni, A.P., Giordano, B., Montella, F., Caliendo, S., Tufano, M.A.
Format Journal Article
LanguageEnglish
Published Basel, Switzerland Karger 01.01.1999
S. Karger AG
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Abstract We studied the in vitro susceptibility of 80 Helicobacter pylori clinical isolates to several antimicrobials commonly used to treat the infection, using the Epsilometer test (E-test). We also compared E-test and disk diffusion test in determining H. pylori susceptibility to the same antibiotics. We found a high prevalence of H. pylori strains resistant to metronidazole (23.7%), whereas the prevalence of H. pylori strains resistant to clarithromycin was 10%. Also, a significant correlation was found between MICs obtained with the disk diffusion test and E-test for metronidazole and clarithromycin. In conclusion, our study confirms a high prevalence of metronidazole- or clarithromycin-resistant H. pylori strains. Also, our data suggest that the E-test is a single, reliable, and cost-effective method to assess in vitro susceptibility of H. pylori to antimicrobial agents commonly used to eradicate the infection.
AbstractList We studied the in vitro susceptibility of 80 Helicobacter pylori clinical isolates to several antimicrobials commonly used to treat the infection, using the Epsilometer test (E-test). We also compared E-test and disk diffusion test in determining H. pylori susceptibility to the same antibiotics. We found a high prevalence of H. pylori strains resistant to metronidazole (23.7%), whereas the prevalence of H. pylori strains resistant to clarithromycin was 10%. Also, a significant correlation was found between MICs obtained with the disk diffusion test and E-test for metronidazole and clarithromycin. In conclusion, our study confirms a high prevalence of metronidazole- or clarithromycin-resistant H. pylori strains. Also, our data suggest that the E-test is a single, reliable, and cost-effective method to assess in vitro susceptibility of H. pylori to antimicrobial agents commonly used to eradicate the infection.
Author Caliendo, S.
Iovene, M.R.
Romano, M.
Montella, F.
Pilloni, A.P.
Giordano, B.
Tufano, M.A.
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Cites_doi 10.1001/jama.272.1.65
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Keywords Helicobacter pylori
E-test
Antimicrobialresistance
Human
Spirillales
Drug susceptibility test
Spirillaceae
Bacteria
Antibacterial agent
In vitro
Clinical isolate
Language English
License Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
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SubjectTerms Adult
Aged
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Drug Resistance, Microbial
Evaluation Studies as Topic
Female
Helicobacter Infections - microbiology
Helicobacter pylori
Helicobacter pylori - drug effects
Helicobacter pylori - isolation & purification
Humans
Male
Medical sciences
Microbial Sensitivity Tests - methods
Microbiology
Middle Aged
Pharmacology. Drug treatments
Title Prevalence of Antimicrobial Resistance in Eighty Clinical Isolates of Helicobacter pylori
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