The p24 Complex Contributes to Specify Arf1 for COPI Coat Selection

• Published in: International journal of molecular sciences Vol. 22; no. 1; p. 423
• Main Authors: Sabido-Bozo, Susana, Perez-Linero, Ana, Manzano-Lopez, Javier, Rodriguez-Gallardo, Sofia, Aguilera-Romero, Auxiliadora, Cortes-Gomez, Alejandro, Lopez, Sergio, Wellinger, Ralf, Muñiz, Manuel
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 03.01.2021; MDPI
• Subjects: ADP-Ribosylation Factor 1 - genetics; ADP-Ribosylation Factor 1 - metabolism; Coat Protein Complex I - genetics; Coat Protein Complex I - metabolism; COP-Coated Vesicles - metabolism; Golgi Apparatus - metabolism; Guanine Nucleotide Exchange Factors - genetics; Guanine Nucleotide Exchange Factors - metabolism; Peptides; Protein Transport; Proteins; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - growth & development; Saccharomyces cerevisiae - metabolism; Saccharomyces cerevisiae Proteins - genetics; Saccharomyces cerevisiae Proteins - metabolism; Yeast; COPI; Golgi; Arf1; p24 complex; ArfGEFs

Golgi trafficking depends on the small GTPase Arf1 which, upon activation, drives the assembly of different coats onto budding vesicles. Two related types of guanine nucleotide exchange factors (GEFs) activate Arf1 at different Golgi sites. In yeast, Gea1 in the cis-Golgi and Gea2 in the medial-Golg...