Muscle-specific activation of Ca2+/calmodulin-dependent protein kinase IV increases whole-body insulin action in mice

• Published in: Diabetologia Vol. 57; no. 6; pp. 1232 - 1241
• Main Authors: Lee, Hui-Young, Gattu, Arijeet K., Camporez, João-Paulo G., Kanda, Shoichi, Guigni, Blas, Kahn, Mario, Zhang, Dongyan, Galbo, Thomas, Birkenfeld, Andreas L., Jornayvaz, Francois R., Jurczak, Michael J., Choi, Cheol Soo, Yan, Zhen, Williams, R. Sanders, Shulman, Gerald I., Samuel, Varman T.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2014; Springer
• Subjects: Biological and medical sciences; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Human Physiology; Internal Medicine; Medical sciences; Medicine; Medicine & Public Health; Metabolic Diseases; Myokines; Muscle insulin resistance; Hyperinsulinaemic–euglycaemic clamp; Endocrinopathy; Pancreatic hormone; Calcium; Enzyme; Transferases; Diabetes mellitus; Non-specific serine/threonine protein kinase; Rodentia; Metabolic diseases; Hyperinsulinaemic-euglycaemic clamp; Inorganic element; Insulin; Target tissue resistance; Vertebrata; Mammalia; Mouse; Animal; Insulin resistance; Muscle; Calmodulin

Aims/hypothesis Aerobic exercise increases muscle glucose and improves insulin action through numerous pathways, including activation of Ca 2+ /calmodulin-dependent protein kinases (CAMKs) and peroxisome proliferator γ coactivator 1α (PGC-1α). While overexpression of PGC-1α increases muscle mitochon...