Esophageal and Small Intestinal Mucosal Integrity in Eosinophilic Esophagitis and Response to an Elemental Diet

• Published in: The American journal of gastroenterology Vol. 112; no. 7; pp. 1061 - 1071
• Main Authors: Warners, Marijn J, Vlieg-Boerstra, Berber J, Verheij, Joanne, van Hamersveld, Patricia H P, van Rhijn, Bram D, Van Ampting, Marleen T J, Harthoorn, Lucien F, de Jonge, Wouter J, Smout, Andreas J P M, Bredenoord, Albert J
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins 01.07.2017; Nature Publishing Group
• Subjects: Adult; Autoimmune diseases; Biopsy; Case-Control Studies; Electric Impedance; Endoscopy, Digestive System; Eosinophilic Esophagitis - diet therapy; Eosinophilic Esophagitis - pathology; Esophageal diseases; Esophagus; Esophagus - pathology; Female; Food, Formulated; Gastroenterology; Gastrointestinal diseases; Gene expression; Humans; Intestinal Mucosa - pathology; Intestine, Small - pathology; Male; Middle Aged; Permeability; Prospective Studies; Real-Time Polymerase Chain Reaction; Treatment Outcome

The esophageal mucosal integrity is impaired in eosinophilic esophagitis (EoE) and it has been suggested that the duodenal permeability is increased. The absence of food allergens may restore the integrity. The aims of this study were to assess duodenal permeability in EoE and to evaluate the effect...