Recent advancements to engineer mesenchymal stem cells and their extracellular vesicles for targeting and destroying tumors

• Published in: PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY Vol. 178; pp. 1 - 16
• Main Authors: Karami Fath, Mohsen, Moayedi Banan, Zahra, Barati, Reza, Mohammadrezakhani, Omid, Ghaderi, Aliasghar, Hatami, Ali, Ghiabi, Shamim, Zeidi, Nazanin, Asgari, Katayoon, Payandeh, Zahra, Barati, Ghasem
• Format: Journal Article Publication
• Language: English
• Published: England Elsevier Ltd 01.03.2023
• Subjects: Antineoplastic Agents; Extracellular vesicles; Extracellular Vesicles - metabolism; Genetically engineered MSCs; Humans; Mesenchymal stem cells; Mesenchymal Stem Cells - metabolism; Neoplasms - metabolism; Oncolytic virotherapy; Targeted tumor therapy; Tumor Microenvironment; Extracellular vesicles; Oncolytic virotherapy; Genetically engineered MSCs; Targeted tumor therapy; Mesenchymal stem cells

Mesenchymal stem cells (MSCs) have the ability to migrate into tumor sites and release growth factors to modulate the tumor microenvironment. MSC therapy have shown a dual role in cancers, promoting or inhibiting. However, MSCs could be used as a carrier of anticancer agents for targeted tumor thera...