In Vitro Antitumor Activity of Aloperine on Human Thyroid Cancer Cells through Caspase-Dependent Apoptosis

• Published in: International journal of molecular sciences Vol. 19; no. 1; p. 312
• Main Authors: Lee, Ying-Ray, Chen, Shu-Hsin, Lin, Ching-Yen, Chao, Wen-Ying, Lim, Yun-Ping, Yu, Hui-I, Lu, Chieh-Hsiang
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 21.01.2018; MDPI
• Subjects: Antineoplastic Agents - pharmacology; Apoptosis; Apoptosis - drug effects; Biomarkers; Caspases - metabolism; Cell cycle; Cell Cycle - drug effects; Cell Line, Tumor; Cell Proliferation - drug effects; Cell Transformation, Neoplastic - genetics; Cell Transformation, Neoplastic - metabolism; Flow Cytometry; Humans; Neuroendocrine tumors; Piperidines - pharmacology; Proto-Oncogene Proteins c-akt - metabolism; Signal Transduction - drug effects; Thyroid cancer; Thyroid Neoplasms - genetics; Thyroid Neoplasms - metabolism; Thyroid Neoplasms - pathology; apoptosis; thyroid cancer; aloperine

The global incidence of thyroid cancer, one of the most common endocrine malignancies, is especially high among women. Although most patients with thyroid cancers exhibit a good prognosis with standard treatment, there are no effective therapies for patients with anaplastic thyroid cancers or cancer...