Gap Junctions between Endothelial Cells Are Disrupted by Circulating Extracellular Vesicles from Sickle Cell Patients with Acute Chest Syndrome

• Published in: International journal of molecular sciences Vol. 21; no. 23; p. 8884
• Main Authors: Gemel, Joanna, Mao, Yifan, Lapping-Carr, Gabrielle, Beyer, Eric C.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 24.11.2020; MDPI
• Subjects: Acute Chest Syndrome - complications; Acute Chest Syndrome - genetics; Acute Chest Syndrome - pathology; Adolescent; Adult; Anemia, Sickle Cell - complications; Anemia, Sickle Cell - genetics; Anemia, Sickle Cell - pathology; Animals; Cell Communication - genetics; Child; Child, Preschool; Connexin 43 - genetics; Endothelial Cells - metabolism; Endothelium - metabolism; Endothelium - pathology; Extracellular vesicles; Extracellular Vesicles - genetics; Female; Gap Junctions - genetics; Hemoglobin; Humans; Intercellular Junctions - genetics; Lipids; Male; Membranes; MicroRNAs; Nanoparticles; Plasma; Proteins; Young Adult; endothelium; endothelial integrity; Connexin43; gap junction; extracellular vesicle; tight junction; sickle cell disease

Intercellular junctions maintain the integrity of the endothelium. We previously found that the adherens and tight junctions between endothelial cells are disrupted by plasma extracellular vesicles from patients with sickle cell disease (especially those with Acute Chest Syndrome). In the current st...