The Apoptosis Paradox in Cancer

• Published in: International journal of molecular sciences Vol. 23; no. 3; p. 1328
• Main Authors: Morana, Ornella, Wood, Will, Gregory, Christopher D.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.01.2022; MDPI
• Subjects: Angiogenesis; Animals; Apoptosis; Apoptosis - physiology; Cancer therapies; Cell Proliferation - physiology; Cell Survival - physiology; Cloning; Evolution; Humans; Immunity, Innate - physiology; Lymphoma; Medical prognosis; Neoplasms - pathology; Phagocytes - physiology; Physiology; Review; Tumor Microenvironment - physiology; Tumors; cancer therapy; repair; cell death; regeneration; tumour; immune system; apoptosis; macrophage; cancer; extracellular vesicle

Cancer growth represents a dysregulated imbalance between cell gain and cell loss, where the rate of proliferating mutant tumour cells exceeds the rate of those that die. Apoptosis, the most renowned form of programmed cell death, operates as a key physiological mechanism that limits cell population...