Tumor Microenvironment: A Metabolic Player that Shapes the Immune Response

• Published in: International journal of molecular sciences Vol. 21; no. 1; p. 157
• Main Authors: Cassim, Shamir, Pouyssegur, Jacques
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.12.2019; MDPI
• Subjects: Amino Acids - metabolism; Antigens; Bioenergetics; Biosynthesis; Cancer; Cell division; Enzymes; Epigenetics; Fatty acids; Genotype & phenotype; Glucose; Glucose - metabolism; Humans; Immune response; Immunity; Kinases; Lactic Acid - metabolism; Lymphocytes; Lymphocytes - immunology; Lymphocytes - metabolism; Medical prognosis; Metabolism; Mutation; Neoplasms - metabolism; Neoplasms - pathology; Nutrients; Review; T cell receptors; Tumor Microenvironment; Tumors; microenvironment; tumor acidity; cancer; metabolism; immunity; lactate; nutrients

Immune cells survey and patrol throughout the body and sometimes take residence in niche environments with distinct cellular subtypes and nutrients that may fluctuate from those in which they matured. Rooted in immune cell physiology are metabolic pathways and metabolites that not only deliver subst...