Nanog Signaling Mediates Radioresistance in ALDH-Positive Breast Cancer Cells

• Published in: International journal of molecular sciences Vol. 20; no. 5; p. 1151
• Main Authors: Dehghan Harati, Mozhgan, Rodemann, H. Peter, Toulany, Mahmoud
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 06.03.2019; MDPI
• Subjects: Breast cancer; Cancer therapies; Chemotherapy; Deoxyribonucleic acid; DNA; DNA damage; Enzymes; Investigations; Phosphorylation; Proteins; Radiation therapy; Stem cells; Akt; Nanog; cancer stem cells; ALDH1; radioresistance; Notch

Recently, cancer stem cells (CSCs) have been identified as the major cause of both chemotherapy and radiotherapy resistance. Evidence from experimental studies applying both in vitro and in vivo preclinical models suggests that CSCs survive after conventional therapy protocols. Several mechanisms ar...