Genome-wide association study confirms lung cancer susceptibility loci on chromosomes 5p15 and 15q25 in an African-American population

• Published in: Lung cancer (Amsterdam, Netherlands) Vol. 98; pp. 33 - 42
• Main Authors: Zanetti, Krista A., Wang, Zhaoming, Aldrich, Melinda, Amos, Christopher I., Blot, William J., Bowman, Elise D., Burdette, Laurie, Cai, Qiuyin, Caporaso, Neil, Chung, Charles C., Gillanders, Elizabeth M., Haiman, Christopher A., Hansen, Helen M., Henderson, Brian E., Kolonel, Laurence N., Marchand, Loic Le, Li, Shengchao, McNeill, Lorna Haughton, Ryan, Bríd M., Schwartz, Ann G., Sison, Jennette D., Spitz, Margaret R., Tucker, Margaret, Wenzlaff, Angela S., Wiencke, John K., Wilkens, Lynne, Wrensch, Margaret R., Wu, Xifeng, Zheng, Wei, Zhou, Weiyin, Christiani, David, Palmer, Julie R., Penning, Trevor M., Rieber, Alyssa G., Rosenberg, Lynn, Ruiz-Narvaez, Edward A., Su, Li, Vachani, Anil, Wei, Yongyue, Whitehead, Alexander S., Chanock, Stephen J., Harris, Curtis C.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.08.2016
• Subjects: African Americans; Black or African American - genetics; Case-Control Studies; Chromosomes, Human, Pair 15; Chromosomes, Human, Pair 5; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Lung neoplasms; Lung Neoplasms - epidemiology; Lung Neoplasms - genetics; Polymorphism, Single Nucleotide; Population Surveillance; Quantitative Trait Loci; Receptors, Cholinergic; Smoking; Telomerase; African Americans; Genome-wide association study; Telomerase; Receptors, Cholinergic; Lung neoplasms; Smoking

•Confirmed previous reports that two loci on 15q25.1 and 5p15.33 are associated with lung cancer.•Two loci associated with lung cancer are near plausible candidate genes, CHRNA5 and TERT.•No SNPs reached genome-wide significance for the main effect model examining cigarettes per day. Genome-wide ass...