Encephalopathy induced by high levels of ceftriaxone in the blood and cerebrospinal fluid
Ceftriaxone is commonly used to treat bacterial infections. Encephalopathy is a rare adverse effect of ceftriaxone therapy, and most cases have been diagnosed based on medical history. We report a case of a 73-year-old woman with ceftriaxone-associated encephalopathy, which was confirmed by measurin...
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| Published in | IDCases Vol. 29; p. e01581 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier
01.01.2022
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| Subjects | |
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| Abstract | Ceftriaxone is commonly used to treat bacterial infections. Encephalopathy is a rare adverse effect of ceftriaxone therapy, and most cases have been diagnosed based on medical history. We report a case of a 73-year-old woman with ceftriaxone-associated encephalopathy, which was confirmed by measuring the ceftriaxone levels in the blood and cerebrospinal fluid. She regularly underwent hemodialysis. She received intravenous ceftriaxone at a dose of 1 g/day for 4 days for enteritis, and mental status began to be disturbed during the therapy. Six days after ceftriaxone discontinuation, her consciousness level rapidly improved. Thus, ceftriaxone-associated encephalopathy was suspected. High ceftriaxone levels in the blood and cerebrospinal fluid were observed while the patient had disturbed consciousness. This case indicated that high ceftriaxone levels in the blood and cerebrospinal fluid were related to development of encephalopathy. The estimation of ceftriaxone levels may be useful for an accurate diagnosis. |
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| AbstractList | Ceftriaxone is commonly used to treat bacterial infections. Encephalopathy is a rare adverse effect of ceftriaxone therapy, and most cases have been diagnosed based on medical history. We report a case of a 73-year-old woman with ceftriaxone-associated encephalopathy, which was confirmed by measuring the ceftriaxone levels in the blood and cerebrospinal fluid. She regularly underwent hemodialysis. She received intravenous ceftriaxone at a dose of 1 g/day for 4 days for enteritis, and mental status began to be disturbed during the therapy. Six days after ceftriaxone discontinuation, her consciousness level rapidly improved. Thus, ceftriaxone-associated encephalopathy was suspected. High ceftriaxone levels in the blood and cerebrospinal fluid were observed while the patient had disturbed consciousness. This case indicated that high ceftriaxone levels in the blood and cerebrospinal fluid were related to development of encephalopathy. The estimation of ceftriaxone levels may be useful for an accurate diagnosis. |
| ArticleNumber | e01581 |
| Author | Minamii, Takahiro Shimizu, Hayato Irie, Kei Nishioka, Hiroaki |
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| Cites_doi | 10.1128/AAC.24.4.529 10.2169/internalmedicine.1785-18 10.1128/AAC.22.5.816 10.1007/s11357-020-00211-2 10.1128/AAC.39.1.232 10.1186/s13054-016-1522-z 10.1136/postgradmedj-2017-134999 10.1016/j.ijantimicag.2003.11.004 10.1128/AAC.37.7.1518 10.1212/WNL.0000000000002023 10.1016/S0749-0704(05)70367-5 10.1016/j.ekir.2017.03.009 |
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| References | Chow (10.1016/j.idcr.2022.e01581_bib15) 2004; 23 Roncon-Albuquerque (10.1016/j.idcr.2022.e01581_bib1) 2009; 67 Jadot (10.1016/j.idcr.2022.e01581_bib6) 2021; 8 Sutter (10.1016/j.idcr.2022.e01581_bib14) 2015; 85 Safadi (10.1016/j.idcr.2022.e01581_bib2) 2014; 2014 Suzuki (10.1016/j.idcr.2022.e01581_bib5) 2019; 58 Dubin (10.1016/j.idcr.2022.e01581_bib4) 2018; 94 Gilbert (10.1016/j.idcr.2022.e01581_bib7) 2021 Pollock (10.1016/j.idcr.2022.e01581_bib8) 1982; 22 Nau (10.1016/j.idcr.2022.e01581_bib9) 1993; 37 Inoue (10.1016/j.idcr.2022.e01581_bib3) 2017; 2 Verheggen (10.1016/j.idcr.2022.e01581_bib16) 2020; 42 Wallace (10.1016/j.idcr.2022.e01581_bib10) 1997; 13 Cohen (10.1016/j.idcr.2022.e01581_bib13) 1983; 24 Chaïbi (10.1016/j.idcr.2022.e01581_bib12) 2016; 20 De Sarro (10.1016/j.idcr.2022.e01581_bib11) 1995; 39 |
| References_xml | – volume: 24 start-page: 529 year: 1983 ident: 10.1016/j.idcr.2022.e01581_bib13 article-title: Pharmacokinetics of ceftriaxone in patients with renal failure and in those undergoing hemodialysis publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.24.4.529 contributor: fullname: Cohen – volume: 58 start-page: 1775 year: 2019 ident: 10.1016/j.idcr.2022.e01581_bib5 article-title: Encephalopathy induced by high plasma and cerebrospinal fluid ceftriaxone concentrations in a hemodialysis patient publication-title: Intern Med doi: 10.2169/internalmedicine.1785-18 contributor: fullname: Suzuki – year: 2021 ident: 10.1016/j.idcr.2022.e01581_bib7 contributor: fullname: Gilbert – volume: 22 start-page: 816 year: 1982 ident: 10.1016/j.idcr.2022.e01581_bib8 article-title: Pharmacokinetic characteristics of intravenous ceftriaxone in normal adults publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.22.5.816 contributor: fullname: Pollock – volume: 42 start-page: 1183 year: 2020 ident: 10.1016/j.idcr.2022.e01581_bib16 article-title: Increase in blood–brain barrier leakage in healthy, older adults publication-title: GeroScience doi: 10.1007/s11357-020-00211-2 contributor: fullname: Verheggen – volume: 39 start-page: 232 year: 1995 ident: 10.1016/j.idcr.2022.e01581_bib11 article-title: Relationship between structure and convulsant properties of some beta-lactam antibiotics following intracerebroventricular microinjection in rats publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.39.1.232 contributor: fullname: De Sarro – volume: 20 start-page: 350 year: 2016 ident: 10.1016/j.idcr.2022.e01581_bib12 article-title: Not all β-lactams are equal regarding neurotoxicity publication-title: Crit Care doi: 10.1186/s13054-016-1522-z contributor: fullname: Chaïbi – volume: 67 start-page: 72 year: 2009 ident: 10.1016/j.idcr.2022.e01581_bib1 article-title: Ceftriaxone-induced acute reversible encephalopathy in a patient treated for a urinary tract infection publication-title: Neth J Med contributor: fullname: Roncon-Albuquerque – volume: 8 year: 2021 ident: 10.1016/j.idcr.2022.e01581_bib6 article-title: Ceftriaxone-induced encephalopathy: a pharmacokinetic approach publication-title: Eur J Case Rep Intern Med contributor: fullname: Jadot – volume: 94 start-page: 357 year: 2018 ident: 10.1016/j.idcr.2022.e01581_bib4 article-title: Iatrogenic coma: ceftriaxone-associated encephalopathy publication-title: Post Med J doi: 10.1136/postgradmedj-2017-134999 contributor: fullname: Dubin – volume: 23 start-page: 213 year: 2004 ident: 10.1016/j.idcr.2022.e01581_bib15 article-title: Mechanisms of antibiotic neurotoxicity in renal failure publication-title: Int J Antimicrob Agents doi: 10.1016/j.ijantimicag.2003.11.004 contributor: fullname: Chow – volume: 37 start-page: 1518 year: 1993 ident: 10.1016/j.idcr.2022.e01581_bib9 article-title: Passage of cefotaxime and ceftriaxone into cerebrospinal fluid of patients with uninflamed meninges publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.37.7.1518 contributor: fullname: Nau – volume: 85 start-page: 1332 year: 2015 ident: 10.1016/j.idcr.2022.e01581_bib14 article-title: Seizures as adverse events of antibiotic drugs: a systematic review publication-title: Neurology doi: 10.1212/WNL.0000000000002023 contributor: fullname: Sutter – volume: 13 start-page: 741 year: 1997 ident: 10.1016/j.idcr.2022.e01581_bib10 article-title: Antibiotic-induced convulsions publication-title: Crit Care Clin doi: 10.1016/S0749-0704(05)70367-5 contributor: fullname: Wallace – volume: 2014 year: 2014 ident: 10.1016/j.idcr.2022.e01581_bib2 article-title: Ceftriaxone-induced acute encephalopathy in a peritoneal dialysis patient publication-title: Case Rep Nephrol contributor: fullname: Safadi – volume: 2 start-page: 984 year: 2017 ident: 10.1016/j.idcr.2022.e01581_bib3 article-title: Three cases of hemodialysis patients receiving high-dose ceftriaxone: serum concentrations and its neurotoxicity publication-title: Kidney Int Rep doi: 10.1016/j.ekir.2017.03.009 contributor: fullname: Inoue |
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| Title | Encephalopathy induced by high levels of ceftriaxone in the blood and cerebrospinal fluid |
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