Rapid and scale-independent microfluidic manufacture of liposomes entrapping protein incorporating in-line purification and at-line size monitoring

• Published in: International journal of pharmaceutics Vol. 556; pp. 68 - 81
• Main Authors: Forbes, Neil, Hussain, Maryam T., Briuglia, Maria L., Edwards, Darren P., Horst, Joop H. ter, Szita, Nicolas, Perrie, Yvonne
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 10.02.2019
• Subjects: Continuous; Formulation; Liposomes; Manufacture; Microfluidics; Protein; Scale-independent; Continuous; Formulation; Liposomes; Manufacture; Scale-independent; Protein; Microfluidics

[Display omitted] Within this paper we present work that has the ability to de-risk the translation of liposomes from bench to the clinic. We have used microfluidics for the rapid and scale-independent manufacture of liposomes and have incorporated in-line purification and at-line monitoring of part...