Association between Plasma HMGB-1 and Silicosis: A Case-Control Study

• Published in: International journal of molecular sciences Vol. 19; no. 12; p. 4043
• Main Authors: Ma, Jixuan, Zhou, Yun, Li, Wei, Xiao, Lili, Yang, Meng, Tan, Qiyou, Xu, Yiju, Chen, Weihong
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 14.12.2018; MDPI
• Subjects: Biomarkers; Chronic obstructive pulmonary disease; Collagen; Health care; Plasma; Proteins; Pulmonary fibrosis; Silica dust; Silicosis; China; silicosis; biomarker; high mobility group box-1

High-mobility group box-1 (HMGB-1) has been associated with fibrotic diseases. However, the role of HMGB-1 in silicosis is still uncertain. In this study, we conducted a case-control study involving 74 patients with silicosis and 107 age/gender-matched healthy controls in China. An Enzyme-linked imm...