Chagas Disease Drug Discovery: Toward a New Era

• Published in: Journal of biomolecular screening Vol. 20; no. 1; pp. 22 - 35
• Main Author: Chatelain, Eric
• Format: Journal Article
• Language: English
• Published: United States 01.01.2015
• Subjects: Chagas Disease - drug therapy; Chagas Disease - parasitology; Clinical Trials as Topic; Drug Discovery - methods; Drug Discovery - trends; Humans; Treatment Outcome; Trypanocidal Agents - pharmacology; Trypanocidal Agents - therapeutic use; Trypanosoma cruzi - physiology; compound progression criteria; translation; drug discovery; secondary assays; Trypanosoma cruzi

American trypanosomiasis, or Chagas disease, is the result of infection by the Trypanosoma cruzi parasite. Endemic in Latin America where it is the major cause of death from cardiomyopathy, the impact of the disease is reaching global proportions through migrating populations. New drugs that are saf...