The Epigenetic Landscape of Vascular Calcification: An Integrative Perspective

• Published in: International journal of molecular sciences Vol. 21; no. 3; p. 980
• Main Authors: Hou, Yi-Chou, Lu, Chien-Lin, Yuan, Tzu-Hang, Liao, Min-Tser, Chao, Chia-Ter, Lu, Kuo-Cheng
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.02.2020; MDPI
• Subjects: Calcification; DNA methylation; Epigenetics; Growth factors; Kinases; MicroRNAs; Pathogenesis; Review; Smooth muscle; Transcription factors; chronic kidney disease; epigenetic; vascular calcification; phosphate; microRNA; diabetes mellitus; medial calcification; vascular smooth muscle cells

Vascular calcification (VC) is an important complication among patients of advanced age, those with chronic kidney disease, and those with diabetes mellitus. The pathophysiology of VC encompasses passive occurrence of physico-chemical calcium deposition, active cellular secretion of osteoid matrix u...