Pediatric pancreatoblastoma: histopathologic and cytogenetic characterization of tumor and derived cell line
Little is known of the molecular events underlying the genesis of pancreatoblastoma tumors in the pediatric population. Such studies have been limited by the rare nature of the disease, infrequent reports detailing cytogenetic alterations, and the lack of availability of cell lines for biologic stud...
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| Published in | Cancer genetics and cytogenetics Vol. 157; no. 2; pp. 109 - 117 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.03.2005
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| Abstract | Little is known of the molecular events underlying the genesis of pancreatoblastoma tumors in the pediatric population. Such studies have been limited by the rare nature of the disease, infrequent reports detailing cytogenetic alterations, and the lack of availability of cell lines for biologic studies. We present the isolation of a cell line from a 14-year-old boy with malignant pancreatoblastoma, and its cytogenetic characterization using spectral karyotyping and comparative genomic hybridization (CGH). The cytogenetic analysis revealed an exceedingly complex cytogenetic karyotype, with 33 aberrant chromosomes. CGH revealed multiple regions of chromosomal loss and gain, including a region on 8q gained in adult pancreatic cancers, one that frequently contains the
MYC oncogene. |
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| AbstractList | Little is known of the molecular events underlying the genesis of pancreatoblastoma tumors in the pediatric population. Such studies have been limited by the rare nature of the disease, infrequent reports detailing cytogenetic alterations, and the lack of availability of cell lines for biologic studies. We present the isolation of a cell line from a 14-year-old boy with malignant pancreatoblastoma, and its cytogenetic characterization using spectral karyotyping and comparative genomic hybridization (CGH). The cytogenetic analysis revealed an exceedingly complex cytogenetic karyotype, with 33 aberrant chromosomes. CGH revealed multiple regions of chromosomal loss and gain, including a region on 8q gained in adult pancreatic cancers, one that frequently contains the MYC oncogene. Little is known of the molecular events underlying the genesis of pancreatoblastoma tumors in the pediatric population. Such studies have been limited by the rare nature of the disease, infrequent reports detailing cytogenetic alterations, and the lack of availability of cell lines for biologic studies. We present the isolation of a cell line from a 14-year-old boy with malignant pancreatoblastoma, and its cytogenetic characterization using spectral karyotyping and comparative genomic hybridization (CGH). The cytogenetic analysis revealed an exceedingly complex cytogenetic karyotype, with 33 aberrant chromosomes. CGH revealed multiple regions of chromosomal loss and gain, including a region on 8q gained in adult pancreatic cancers, one that frequently contains the MYC oncogene. |
| Author | Tsokos, Maria Padilla-Nash, Hesed Thiele, Carol J. Barenboim-Stapleton, Linda Ried, Thomas Wigginton, Jon M. Yang, Xuezhong |
| Author_xml | – sequence: 1 givenname: Linda surname: Barenboim-Stapleton fullname: Barenboim-Stapleton, Linda organization: Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health (NCI/NIH), Bethesda, MD – sequence: 2 givenname: Xuezhong surname: Yang fullname: Yang, Xuezhong organization: Cell & Molecular Biology Section, Pediatric Oncology Branch, Center for Cancer Research, NCI/NIH, Bethesda, MD 20892 – sequence: 3 givenname: Maria surname: Tsokos fullname: Tsokos, Maria organization: Pathology Laboratory, Center for Cancer Research, NCI/NIH, Bethesda, MD – sequence: 4 givenname: Jon M. surname: Wigginton fullname: Wigginton, Jon M. organization: Cell & Molecular Biology Section, Pediatric Oncology Branch, Center for Cancer Research, NCI/NIH, Bethesda, MD 20892 – sequence: 5 givenname: Hesed surname: Padilla-Nash fullname: Padilla-Nash, Hesed organization: Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health (NCI/NIH), Bethesda, MD – sequence: 6 givenname: Thomas surname: Ried fullname: Ried, Thomas organization: Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health (NCI/NIH), Bethesda, MD – sequence: 7 givenname: Carol J. surname: Thiele fullname: Thiele, Carol J. email: ct47@nih.gov organization: Cell & Molecular Biology Section, Pediatric Oncology Branch, Center for Cancer Research, NCI/NIH, Bethesda, MD 20892 |
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| CitedBy_id | crossref_primary_10_1097_01_mpa_0000240610_33936_cb crossref_primary_10_1097_PPO_0b013e31827459b6 crossref_primary_10_1016_j_canlet_2008_01_026 crossref_primary_10_1038_nprot_2006_358 crossref_primary_10_1007_s00383_019_04524_y crossref_primary_10_1097_MPH_0b013e3182707577 crossref_primary_10_1007_s12079_021_00661_z crossref_primary_10_1684_bdc_2012_1600 crossref_primary_10_1016_j_cpet_2008_10_004 crossref_primary_10_4132_jptm_2014_12_26 crossref_primary_10_3171_ped_2007_106_2_169 |
| Cites_doi | 10.1016/0165-4608(96)85319-2 10.1016/0165-4608(94)00117-T 10.1016/S0037-1963(00)90014-3 10.3322/canjclin.50.1.7 10.1002/mpo.10050 10.1016/S0002-9440(10)65298-4 10.1016/S0002-9440(10)63008-8 10.1007/s004180050169 10.1016/0735-0651(87)90021-5 10.1016/S0046-8177(99)90244-7 10.1002/gcc.1111 10.1126/science.273.5274.494 10.1159/000050103 |
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disease publication-title: Genes Chromosomes Cancer doi: 10.1002/gcc.1111 contributor: fullname: Phillips – volume: 273 start-page: 494 year: 1996 ident: 10.1016/j.cancergencyto.2004.05.017_bib10 article-title: Multicolor spectral karyotyping of human chromosomes publication-title: Science doi: 10.1126/science.273.5274.494 contributor: fullname: Schröck – volume: 18 start-page: 78 year: 2001 ident: 10.1016/j.cancergencyto.2004.05.017_bib3 article-title: Pancreatoblastoma: ultrastructural and image DNA cytometric analysis publication-title: Dig Surg doi: 10.1159/000050103 contributor: fullname: Riesener |
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| SubjectTerms | Adolescent Chromosome Aberrations Chromosome Banding Humans In Situ Hybridization, Fluorescence Male Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Spectral Karyotyping Tumor Cells, Cultured |
| Title | Pediatric pancreatoblastoma: histopathologic and cytogenetic characterization of tumor and derived cell line |
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