TOMM40 Genetic Variants Cause Neuroinflammation in Alzheimer’s Disease

• Published in: International journal of molecular sciences Vol. 24; no. 4; p. 4085
• Main Authors: Chen, Yi-Chun, Chang, Shih-Cheng, Lee, Yun-Shien, Ho, Wei-Min, Huang, Yu-Hua, Wu, Yah-Yuan, Chu, Yi-Chuan, Wu, Kuan-Hsuan, Wei, Li-Shan, Wang, Hung-Li, Chiu, Ching-Chi
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 17.02.2023; MDPI
• Subjects: Alzheimer Disease - genetics; Alzheimer Disease - pathology; Alzheimer's disease; Apoptosis; Biobanks; Cytokines; Genes; Genetic Variation; Genomes; Humans; Hypotheses; Inflammasomes - metabolism; Interleukin-6 - metabolism; Kinases; Microglia - metabolism; Mitochondria; Mitochondrial Precursor Protein Import Complex Proteins - genetics; Mutation; Neuroinflammatory Diseases - genetics; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; Oxidative stress; Pathogenesis; Protein expression; Proteins; Tumor necrosis factor-TNF; Taiwan; NF-κB; TOMM40; Alzheimer’s disease; SNP; neuroinflammation; NLRP3; microglia; hippocampal neurons

Translocase of outer mitochondrial membrane 40 (TOMM40) is located in the outer membrane of mitochondria. TOMM40 is essential for protein import into mitochondria. TOMM40 genetic variants are believed to increase the risk of Alzheimer’s disease (AD) in different populations. In this study, three exo...