Y-chromosome and Surname Analyses for Reconstructing Past Population Structures: The Sardinian Population as a Test Case

• Published in: International journal of molecular sciences Vol. 20; no. 22; p. 5763
• Main Authors: Grugni, Viola, Raveane, Alessandro, Colombo, Giulia, Nici, Carmen, Crobu, Francesca, Ongaro, Linda, Battaglia, Vincenza, Sanna, Daria, Al-Zahery, Nadia, Fiorani, Ornella, Lisa, Antonella, Ferretti, Luca, Achilli, Alessandro, Olivieri, Anna, Francalacci, Paolo, Piazza, Alberto, Torroni, Antonio, Semino, Ornella
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 16.11.2019; MDPI
• Subjects: Chromosomes; Chromosomes, Human, Y - classification; Chromosomes, Human, Y - genetics; DNA, Ancient - analysis; European Continental Ancestry Group - genetics; Gene Frequency; Genetic Linkage; Genetics, Population; Geography; Haplotypes; Humans; Islands; Italy; Linguistics; Male; Neolithic; Phylogeny; Population; Principal Component Analysis; Italy; Europe; Anatolia; Caucasus; family name origin; phylogenetics; Human Y-chromosome variation; haplogroups; migrations; peopling of Sardinia
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms20225763

Many anthropological, linguistic, genetic and genomic analyses have been carried out to evaluate the potential impact that evolutionary forces had in shaping the present-day Sardinian gene pool, the main outlier in the genetic landscape of Europe. However, due to the homogenizing effect of internal movements, which have intensified over the past fifty years, only partial information has been obtained about the main demographic events. To overcome this limitation, we analyzed the male-specific region of the Y chromosome in three population samples obtained by reallocating a large number of Sardinian subjects to the place of origin of their monophyletic surnames, which are paternally transmitted through generations in most of the populations, much like the Y chromosome. Three Y-chromosome founding lineages, G2-L91, I2-M26 and R1b-V88, were identified as strongly contributing to the definition of the outlying position of Sardinians in the European genetic context and marking a significant differentiation within the island. The present distribution of these lineages does not always mirror that detected in ancient DNAs. Our results show that the analysis of the Y-chromosome gene pool coupled with a sampling method based on the origin of the family name, is an efficient approach to unravelling past heterogeneity, often hidden by recent movements, in the gene pool of modern populations. Furthermore, the reconstruction and comparison of past genetic isolates represent a starting point to better assess the genetic information deriving from the increasing number of available ancient DNA samples.