Varying Oxygen Partial Pressure Elicits Blood-Borne Microparticles Expressing Different Cell-Specific Proteins—Toward a Targeted Use of Oxygen?

• Published in: International journal of molecular sciences Vol. 23; no. 14; p. 7888
• Main Authors: Balestra, Costantino, Arya, Awadhesh K., Leveque, Clément, Virgili, Fabio, Germonpré, Peter, Lambrechts, Kate, Lafère, Pierre, Thom, Stephen R.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 17.07.2022; MDPI
• Subjects: Adult; Altitude; Antigens; Antioxidants; Aviation; Blood platelets; CD146 Antigen; Endothelial Cells - metabolism; Female; Humans; Hyperbaric Oxygenation; Hyperoxia; Hypoxia; Male; Middle Aged; Neutrophils; Oxidative stress; Oxygen - metabolism; Oxygen therapy; Partial Pressure; Phalloidine; Proteins; altitude; hypoxia; diving; hyperoxia; cellular reactions; hyperoxic-hypoxic paradox; hyperbaric oxygen; decompression sickness; normobaric oxygen paradox
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms23147888

Oxygen is a powerful trigger for cellular reactions, but there are few comparative investigations assessing the effects over a large range of partial pressures. We investigated a metabolic response to single exposures to either normobaric (10%, 15%, 30%, 100%) or hyperbaric (1.4 ATA, 2.5 ATA) oxygen...