Inferring recombination patterns in African populations
Abstract Although several high-resolution recombination maps exist for European-descent populations, the recombination landscape of African populations remains relatively understudied. Given that there is high genetic divergence among groups in Africa, it is possible that recombination hotspots also...
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| Published in | Human molecular genetics Vol. 30; no. R1; pp. R11 - R16 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
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England
Oxford University Press
26.04.2021
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| Abstract | Abstract
Although several high-resolution recombination maps exist for European-descent populations, the recombination landscape of African populations remains relatively understudied. Given that there is high genetic divergence among groups in Africa, it is possible that recombination hotspots also diverge significantly. Both limitations and opportunities exist for developing recombination maps for these populations. In this review, we discuss various recombination inference methods, and the strengths and weaknesses of these methods in analyzing recombination in African-descent populations. Furthermore, we provide a decision tree and recommendations for which inference method to use in various research contexts. Establishing an appropriate methodology for recombination rate inference in a particular study will improve the accuracy of various downstream analyses including but not limited to local ancestry inference, haplotype phasing, fine-mapping of GWAS loci and genome assemblies. |
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| AbstractList | Although several high-resolution recombination maps exist for European-descent populations, the recombination landscape of African populations remains relatively understudied. Given that there is high genetic divergence among groups in Africa, it is possible that recombination hotspots also diverge significantly. Both limitations and opportunities exist for developing recombination maps for these populations. In this review, we discuss various recombination inference methods, and the strengths and weaknesses of these methods in analyzing recombination in African-descent populations. Furthermore, we provide a decision tree and recommendations for which inference method to use in various research contexts. Establishing an appropriate methodology for recombination rate inference in a particular study will improve the accuracy of various downstream analyses including but not limited to local ancestry inference, haplotype phasing, fine-mapping of GWAS loci and genome assemblies. Abstract Although several high-resolution recombination maps exist for European-descent populations, the recombination landscape of African populations remains relatively understudied. Given that there is high genetic divergence among groups in Africa, it is possible that recombination hotspots also diverge significantly. Both limitations and opportunities exist for developing recombination maps for these populations. In this review, we discuss various recombination inference methods, and the strengths and weaknesses of these methods in analyzing recombination in African-descent populations. Furthermore, we provide a decision tree and recommendations for which inference method to use in various research contexts. Establishing an appropriate methodology for recombination rate inference in a particular study will improve the accuracy of various downstream analyses including but not limited to local ancestry inference, haplotype phasing, fine-mapping of GWAS loci and genome assemblies. |
| Author | van Eeden, Gerald Henn, Brenna M Uren, Caitlin Möller, Marlo |
| Author_xml | – sequence: 1 givenname: Gerald surname: van Eeden fullname: van Eeden, Gerald – sequence: 2 givenname: Caitlin surname: Uren fullname: Uren, Caitlin – sequence: 3 givenname: Marlo surname: Möller fullname: Möller, Marlo – sequence: 4 givenname: Brenna M surname: Henn fullname: Henn, Brenna M email: bmhenn@ucdavis.edu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33445180$$D View this record in MEDLINE/PubMed |
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Although several high-resolution recombination maps exist for European-descent populations, the recombination landscape of African populations remains... Although several high-resolution recombination maps exist for European-descent populations, the recombination landscape of African populations remains... |
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| SubjectTerms | Africa Blacks - genetics Decision Trees Evolution, Molecular Genome-Wide Association Study Genomics - methods Haplotypes Humans Invited Review Polymorphism, Single Nucleotide Recombination, Genetic |
| Title | Inferring recombination patterns in African populations |
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