B cell–intrinsic requirement for STK4 in humoral immunity in mice and human subjects

• Published in: Journal of allergy and clinical immunology Vol. 143; no. 6; pp. 2302 - 2305
• Main Authors: Moran, Imogen, Avery, Danielle T., Payne, Kathryn, Lenthall, Helen, Davies, E. Graham, Burns, Siobhan, Ip, Winnie, Oleastro, Matÿfffedas M., Reisli, Ismail, Guner, Sukru, Keles, Sevgi, Notarangelo, Luigi, Deenick, Elissa K., Goodnow, Christopher C., Zahra, David, Brink, Robert, Wong, Melanie, Tangye, Stuart G., Ma, Cindy S., Phan, Tri Giang
• Format: Journal Article
• Language: English
• Published: St. Louis Elsevier Inc 01.06.2019; Elsevier Limited
• Subjects: Antigens; B-cell receptor; Bone marrow; CD69 antigen; CD86 antigen; Defects; Dendritic cells; Human subjects; Humoral immunity; Immunodeficiency; Immunoglobulin A; Immunoglobulin E; Immunoglobulin G; Immunoglobulins; Kinases; Ligands; Lymphocytes B; Lymphocytes T; Lymphopenia; Macrophages; Mutation; Neutropenia; Plasma cells; Protein-serine/threonine kinase
• ISSN: 0091-6749; 1097-6825; 1097-6825
• DOI: 10.1016/j.jaci.2019.02.010

To the Editor: Biallelic loss-of-function mutations in serine-threonine kinase 4 (STK4), also known as mammalian sterile 20-like 1 (MST1), are associated with a combined immunodeficiency characterized by recurrent bacterial, fungal, and viral infections.1-6 Most patients have intermittent neutropeni...