The Role of Integrin α6 (CD49f) in Stem Cells: More than a Conserved Biomarker
Stem cells have the capacity for self-renewal and differentiation into specialized cells that form and repopulated all tissues and organs, from conception to adult life. Depending on their capacity for differentiation, stem cells are classified as totipotent (ie, zygote), pluripotent (ie, embryonic...
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| Published in | Stem cells and development Vol. 26; no. 15; p. 1090 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
United States
01.08.2017
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| Abstract | Stem cells have the capacity for self-renewal and differentiation into specialized cells that form and repopulated all tissues and organs, from conception to adult life. Depending on their capacity for differentiation, stem cells are classified as totipotent (ie, zygote), pluripotent (ie, embryonic stem cells), multipotent (ie, neuronal stem cells, hematopoietic stem cells, epithelial stem cells, etc.), and unipotent (ie, spermatogonial stem cells). Adult or tissue-specific stem cells reside in specific niches located in, or nearby, their organ or tissue of origin. There, they have microenvironmental support to remain quiescent, to proliferate as undifferentiated cells (self-renewal), and to differentiate into progenitors or terminally differentiated cells that migrate from the niche to perform specialized functions. The presence of proteins at the cell surface is often used to identify, classify, and isolate stem cells. Among the diverse groups of cell surface proteins used for these purposes, integrin α6, also known as CD49f, may be the only biomarker commonly found in more than 30 different populations of stem cells, including some cancer stem cells. This broad expression among stem cell populations indicates that integrin α6 may play an important and conserved role in stem cell biology, which is reaffirmed by recent demonstrations of its role maintaining self-renewal of pluripotent stem cells and breast and glioblastoma cancer stem cells. Therefore, this review intends to highlight and synthesize new findings on the importance of integrin α6 in stem cell biology. |
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| AbstractList | Stem cells have the capacity for self-renewal and differentiation into specialized cells that form and repopulated all tissues and organs, from conception to adult life. Depending on their capacity for differentiation, stem cells are classified as totipotent (ie, zygote), pluripotent (ie, embryonic stem cells), multipotent (ie, neuronal stem cells, hematopoietic stem cells, epithelial stem cells, etc.), and unipotent (ie, spermatogonial stem cells). Adult or tissue-specific stem cells reside in specific niches located in, or nearby, their organ or tissue of origin. There, they have microenvironmental support to remain quiescent, to proliferate as undifferentiated cells (self-renewal), and to differentiate into progenitors or terminally differentiated cells that migrate from the niche to perform specialized functions. The presence of proteins at the cell surface is often used to identify, classify, and isolate stem cells. Among the diverse groups of cell surface proteins used for these purposes, integrin α6, also known as CD49f, may be the only biomarker commonly found in more than 30 different populations of stem cells, including some cancer stem cells. This broad expression among stem cell populations indicates that integrin α6 may play an important and conserved role in stem cell biology, which is reaffirmed by recent demonstrations of its role maintaining self-renewal of pluripotent stem cells and breast and glioblastoma cancer stem cells. Therefore, this review intends to highlight and synthesize new findings on the importance of integrin α6 in stem cell biology. |
| Author | Krebsbach, Paul H Villa-Diaz, Luis G |
| Author_xml | – sequence: 1 givenname: Paul H surname: Krebsbach fullname: Krebsbach, Paul H organization: 1 School of Dentistry, University of California , Los Angeles, California – sequence: 2 givenname: Luis G surname: Villa-Diaz fullname: Villa-Diaz, Luis G organization: 2 Department of Biological Sciences, Oakland University , Rochester, Michigan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28494695$$D View this record in MEDLINE/PubMed |
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| Keywords | stem cells niche differentiation self-renewal integrin α6 CD49f |
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| References | 26349061 - Nat Commun. 2015 Sep 08;6:8198 9271670 - Mamm Genome. 1997 Sep;8(9):673-81 21793026 - Hepatology. 2011 Nov;54(5):1830-41 8500165 - Cell. 1993 May 21;73(4):713-24 8673141 - Nat Genet. 1996 Jul;13(3):370-3 20452317 - Cell Stem Cell. 2010 May 7;6(5):421-32 25561492 - Genes Dev. 2015 Jan 1;29(1):1-6 21670270 - Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10544-9 22284662 - BMC Cancer. 2012 Jan 28;12 :48 18055450 - Stem Cells. 2008 Mar;26(3):600-10 21641404 - Am J Pathol. 2011 Jun;178(6):2832-44 6991310 - Dev Biol. 1980 Apr;76(1):100-14 24578244 - Stem Cells. 2014 Jun;32(6):1408-19 12674330 - J Bone Miner Res. 2003 Apr;18(4):696-704 15153612 - Stem Cells. 2004;22(3):355-66 20484027 - Cancer Res. 2010 Jun 1;70(11):4624-33 15989959 - Cell. 2005 Jul 1;121(7):1109-21 14563990 - Science. 2003 Oct 17;302(5644):393; author reply 393 17222404 - Dev Biol. 2007 Mar 1;303(1):29-44 21907166 - Stem Cell Res. 2011 Nov;7(3):230-43 11005869 - Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10960-5 17332515 - Stem Cells. 2007 Mar;25(3):664-9 8530087 - Genomics. 1995 Sep 1;29(1):282-4 12648211 - J Invest Dermatol. 2003 Apr;120(4):501-11 1946438 - Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10183-7 21041368 - Development. 2010 Dec;137(23):3965-71 20332234 - Cancer Res. 2010 Apr 1;70(7):2840-51 18985765 - J Biomed Mater Res A. 2009 Nov;91(2):528-39 21737740 - Science. 2011 Jul 8;333(6039):218-21 10087271 - J Cell Biol. 1999 Mar 22;144(6):1295-309 16690778 - Stem Cells. 2006 Sep;24(9):2078-84 15035980 - Cell. 2004 Mar 19;116(6):769-78 24762436 - J Clin Invest. 2014 Jun;124(6):2378-95 17948866 - J Comp Neurol. 2007 Dec 20;505(6):630-43 7600577 - Cell. 1995 Jun 30;81(7):1095-104 16395311 - Nature. 2006 Feb 23;439(7079):993-7 12145193 - EMBO J. 2002 Aug 1;21(15):3919-26 10318913 - Proc Natl Acad Sci U S A. 1999 May 11;96(10):5504-9 15770794 - Cytotherapy. 2004;6(6):543-53 11093729 - Hepatology. 2000 Dec;32(6):1230-9 15749936 - Stem Cells. 2005 Mar;23 (3):412-23 12595759 - J Biomed Sci. 2003 Mar-Apr;10(2):228-41 21558389 - Cancer Res. 2011 May 15;71(10):3709-19 12454851 - Gastroenterology. 2002 Dec;123(6):1941-8 16051216 - Exp Eye Res. 2005 Sep;81(3):247-64 11581665 - Nat Biotechnol. 2001 Oct;19(10):971-4 15606498 - Differentiation. 2004 Oct;72(8):387-95 19887604 - Cancer Res. 2009 Nov 15;69(22):8555-62 18786416 - Cell Stem Cell. 2008 Sep 11;3(3):289-300 12873811 - J Hepatol. 2003 Aug;39(2):162-70 18466216 - Oral Dis. 2008 Jul;14(5):413-8 11689954 - Nature. 2001 Nov 1;414(6859):98-104 18436868 - Stem Cells. 2008 Jul;26(7):1723-31 26235893 - Stem Cell Reports. 2015 Aug 11;5(2):195-206 24767994 - Cell Rep. 2014 May 8;7(3):747-61 17185413 - Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):181-6 1709048 - Int Immunol. 1991 Feb;3(2):175-84 23906788 - Stem Cell Res. 2013 Nov;11(3):990-1002 18249090 - J Autoimmun. 2008 May;30(3):121-7 9804556 - Science. 1998 Nov 6;282(5391):1145-7 25288800 - J Biol Chem. 2014 Nov 21;289(47):32742-56 12297042 - Cell. 2002 Sep 20;110(6):673-87 27008711 - Oncotarget. 2016 May 31;7(22):31943-54 23071686 - PLoS One. 2012;7(10 ):e46979 16545360 - Dev Biol. 2006 May 15;293(2):414-25 25196208 - Cell Struct Funct. 2014;39(2):101-12 2070796 - Eur J Biochem. 1991 Jul 15;199(2):425-33 20711167 - EMBO J. 2010 Oct 6;29(19):3286-300 24950291 - Stem Cells Dev. 2014 Nov 15;23(22):2744-57 11781341 - J Cell Biol. 2002 Jan 7;156(1):173-84 8012393 - Nat Genet. 1994 Mar;6(3):293-7 23132820 - Stem Cells. 2013 Feb;31(2):317-26 24340075 - PLoS One. 2013 Dec 10;8(12):e83024 9520465 - Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3902-7 10194432 - Blood. 1999 Apr 15;93(8):2533-42 6586833 - J Immunol. 1984 Jul;133(1):157-65 26013602 - Stem Cells. 2015 Sep;33(9):2798-810 22493440 - J Biol Chem. 2012 May 25;287(22):17975-84 26930028 - Stem Cells. 2016 Jul;34(7):1753-64 10975875 - J Comp Neurol. 2000 Oct 2;425(4):479-94 18167064 - Hepatology. 2008 Apr;47(4):1288-97 22980068 - J Thorac Cardiovasc Surg. 2012 Nov;144(5):1192-9 10688781 - Science. 2000 Feb 25;287(5457):1427-30 18818395 - Blood. 2009 Jan 22;113(4):816-26 8306881 - Development. 1993 Dec;119(4):1175-86 17579552 - Cloning Stem Cells. 2007 Summer;9(2):191-205 1384866 - Int Arch Allergy Immunol. 1992;98(4):339-42 9698453 - Dev Biol. 1998 Aug 1;200(1):27-34 12358928 - Br J Haematol. 2002 Oct;119(1):212-20 14671312 - Science. 2004 Jan 16;303(5656):359-63 23436775 - EMBO Mol Med. 2013 Apr;5(4):488-508 7242681 - Nature. 1981 Jul 9;292(5819):154-6 26108791 - Biol Reprod. 2015 Aug;93(2):37 12086642 - Neuron. 2002 Jun 13;34(6):945-60 24497003 - Stem Cells. 2014 Jun;32(6):1380-9 10759420 - Crit Rev Oral Biol Med. 1999;10(2):165-81 15849176 - Stem Cells. 2005 May;23(5):689-98 17872908 - Hum Reprod. 2007 Nov;22(11):2903-11 19088204 - Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20882-7 12529557 - Stem Cells. 2003;21(1):105-10 22122577 - Stem Cells Dev. 2012 Jul 20;21(11):2012-25 18155160 - Biochem Biophys Res Commun. 2008 Mar 7;367(2):256-63 20080639 - Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1414-9 22311737 - Stem Cells. 2012 May;30(5):876-87 10102814 - Science. 1999 Apr 2;284(5411):143-7 16439681 - Blood. 2006 May 1;107(9):3503-10 9472007 - J Cell Sci. 1998 Mar;111 ( Pt 6):793-802 1720038 - Blood. 1991 Dec 1;78(11):2848-53 21131442 - Am J Respir Cell Mol Biol. 2011 Sep;45(3):459-69 22078877 - Cell. 2011 Nov 11;147(4):759-72 16725254 - Cancer Lett. 2007 Mar 8;247(1):1-25 22389315 - Stem Cells. 2012 May;30(5):854-64 |
| References_xml | – reference: 23071686 - PLoS One. 2012;7(10 ):e46979 – reference: 10087271 - J Cell Biol. 1999 Mar 22;144(6):1295-309 – reference: 9271670 - Mamm Genome. 1997 Sep;8(9):673-81 – reference: 9804556 - Science. 1998 Nov 6;282(5391):1145-7 – reference: 18466216 - Oral Dis. 2008 Jul;14(5):413-8 – reference: 18055450 - Stem Cells. 2008 Mar;26(3):600-10 – reference: 21641404 - Am J Pathol. 2011 Jun;178(6):2832-44 – reference: 24762436 - J Clin Invest. 2014 Jun;124(6):2378-95 – reference: 20452317 - Cell Stem Cell. 2010 May 7;6(5):421-32 – reference: 22122577 - Stem Cells Dev. 2012 Jul 20;21(11):2012-25 – reference: 15849176 - Stem Cells. 2005 May;23(5):689-98 – reference: 10318913 - Proc Natl Acad Sci U S A. 1999 May 11;96(10):5504-9 – reference: 16051216 - Exp Eye Res. 2005 Sep;81(3):247-64 – reference: 23436775 - EMBO Mol Med. 2013 Apr;5(4):488-508 – reference: 6586833 - J Immunol. 1984 Jul;133(1):157-65 – reference: 15749936 - Stem Cells. 2005 Mar;23 (3):412-23 – reference: 16439681 - Blood. 2006 May 1;107(9):3503-10 – reference: 17948866 - J Comp Neurol. 2007 Dec 20;505(6):630-43 – reference: 16725254 - Cancer Lett. 2007 Mar 8;247(1):1-25 – reference: 18167064 - Hepatology. 2008 Apr;47(4):1288-97 – reference: 18818395 - Blood. 2009 Jan 22;113(4):816-26 – reference: 11689954 - Nature. 2001 Nov 1;414(6859):98-104 – reference: 22493440 - J Biol Chem. 2012 May 25;287(22):17975-84 – reference: 19088204 - Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20882-7 – reference: 9698453 - Dev Biol. 1998 Aug 1;200(1):27-34 – reference: 12529557 - Stem Cells. 2003;21(1):105-10 – reference: 24497003 - Stem Cells. 2014 Jun;32(6):1380-9 – reference: 26930028 - Stem Cells. 2016 Jul;34(7):1753-64 – reference: 11781341 - J Cell Biol. 2002 Jan 7;156(1):173-84 – reference: 18436868 - Stem Cells. 2008 Jul;26(7):1723-31 – reference: 22389315 - Stem Cells. 2012 May;30(5):854-64 – reference: 26235893 - Stem Cell Reports. 2015 Aug 11;5(2):195-206 – reference: 18155160 - Biochem Biophys Res Commun. 2008 Mar 7;367(2):256-63 – reference: 17872908 - Hum Reprod. 2007 Nov;22(11):2903-11 – reference: 1720038 - Blood. 1991 Dec 1;78(11):2848-53 – reference: 10102814 - Science. 1999 Apr 2;284(5411):143-7 – reference: 20711167 - EMBO J. 2010 Oct 6;29(19):3286-300 – reference: 10194432 - Blood. 1999 Apr 15;93(8):2533-42 – reference: 20080639 - Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1414-9 – reference: 26108791 - Biol Reprod. 2015 Aug;93(2):37 – reference: 10759420 - Crit Rev Oral Biol Med. 1999;10(2):165-81 – reference: 12297042 - Cell. 2002 Sep 20;110(6):673-87 – reference: 12873811 - J Hepatol. 2003 Aug;39(2):162-70 – reference: 21907166 - Stem Cell Res. 2011 Nov;7(3):230-43 – reference: 12086642 - Neuron. 2002 Jun 13;34(6):945-60 – reference: 14563990 - Science. 2003 Oct 17;302(5644):393; author reply 393 – reference: 10975875 - J Comp Neurol. 2000 Oct 2;425(4):479-94 – reference: 20332234 - Cancer Res. 2010 Apr 1;70(7):2840-51 – reference: 21131442 - Am J Respir Cell Mol Biol. 2011 Sep;45(3):459-69 – reference: 8530087 - Genomics. 1995 Sep 1;29(1):282-4 – reference: 12358928 - Br J Haematol. 2002 Oct;119(1):212-20 – reference: 23906788 - Stem Cell Res. 2013 Nov;11(3):990-1002 – reference: 18786416 - Cell Stem Cell. 2008 Sep 11;3(3):289-300 – reference: 7600577 - Cell. 1995 Jun 30;81(7):1095-104 – reference: 24340075 - PLoS One. 2013 Dec 10;8(12):e83024 – reference: 15153612 - Stem Cells. 2004;22(3):355-66 – reference: 17185413 - Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):181-6 – reference: 22284662 - BMC Cancer. 2012 Jan 28;12 :48 – reference: 15770794 - Cytotherapy. 2004;6(6):543-53 – reference: 8673141 - Nat Genet. 1996 Jul;13(3):370-3 – reference: 16395311 - Nature. 2006 Feb 23;439(7079):993-7 – reference: 20484027 - Cancer Res. 2010 Jun 1;70(11):4624-33 – reference: 8012393 - Nat Genet. 1994 Mar;6(3):293-7 – reference: 19887604 - Cancer Res. 2009 Nov 15;69(22):8555-62 – reference: 24578244 - Stem Cells. 2014 Jun;32(6):1408-19 – reference: 12595759 - J Biomed Sci. 2003 Mar-Apr;10(2):228-41 – reference: 18249090 - J Autoimmun. 2008 May;30(3):121-7 – reference: 22311737 - Stem Cells. 2012 May;30(5):876-87 – reference: 6991310 - Dev Biol. 1980 Apr;76(1):100-14 – reference: 21793026 - Hepatology. 2011 Nov;54(5):1830-41 – reference: 11093729 - Hepatology. 2000 Dec;32(6):1230-9 – reference: 11005869 - Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10960-5 – reference: 14671312 - Science. 2004 Jan 16;303(5656):359-63 – reference: 21558389 - Cancer Res. 2011 May 15;71(10):3709-19 – reference: 9472007 - J Cell Sci. 1998 Mar;111 ( Pt 6):793-802 – reference: 11581665 - Nat Biotechnol. 2001 Oct;19(10):971-4 – reference: 27008711 - Oncotarget. 2016 May 31;7(22):31943-54 – reference: 12145193 - EMBO J. 2002 Aug 1;21(15):3919-26 – reference: 15989959 - Cell. 2005 Jul 1;121(7):1109-21 – reference: 15035980 - Cell. 2004 Mar 19;116(6):769-78 – reference: 16690778 - Stem Cells. 2006 Sep;24(9):2078-84 – reference: 22980068 - J Thorac Cardiovasc Surg. 2012 Nov;144(5):1192-9 – reference: 21737740 - Science. 2011 Jul 8;333(6039):218-21 – reference: 21041368 - Development. 2010 Dec;137(23):3965-71 – reference: 26349061 - Nat Commun. 2015 Sep 08;6:8198 – reference: 15606498 - Differentiation. 2004 Oct;72(8):387-95 – reference: 10688781 - Science. 2000 Feb 25;287(5457):1427-30 – reference: 24950291 - Stem Cells Dev. 2014 Nov 15;23(22):2744-57 – reference: 16545360 - Dev Biol. 2006 May 15;293(2):414-25 – reference: 8306881 - Development. 1993 Dec;119(4):1175-86 – reference: 8500165 - Cell. 1993 May 21;73(4):713-24 – reference: 17222404 - Dev Biol. 2007 Mar 1;303(1):29-44 – reference: 17579552 - Cloning Stem Cells. 2007 Summer;9(2):191-205 – reference: 1946438 - Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10183-7 – reference: 7242681 - Nature. 1981 Jul 9;292(5819):154-6 – reference: 21670270 - Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10544-9 – reference: 22078877 - Cell. 2011 Nov 11;147(4):759-72 – reference: 18985765 - J Biomed Mater Res A. 2009 Nov;91(2):528-39 – reference: 1384866 - Int Arch Allergy Immunol. 1992;98(4):339-42 – reference: 25288800 - J Biol Chem. 2014 Nov 21;289(47):32742-56 – reference: 25561492 - Genes Dev. 2015 Jan 1;29(1):1-6 – reference: 17332515 - Stem Cells. 2007 Mar;25(3):664-9 – reference: 2070796 - Eur J Biochem. 1991 Jul 15;199(2):425-33 – reference: 12674330 - J Bone Miner Res. 2003 Apr;18(4):696-704 – reference: 12454851 - Gastroenterology. 2002 Dec;123(6):1941-8 – reference: 26013602 - Stem Cells. 2015 Sep;33(9):2798-810 – reference: 25196208 - Cell Struct Funct. 2014;39(2):101-12 – reference: 1709048 - Int Immunol. 1991 Feb;3(2):175-84 – reference: 12648211 - J Invest Dermatol. 2003 Apr;120(4):501-11 – reference: 9520465 - Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3902-7 – reference: 24767994 - Cell Rep. 2014 May 8;7(3):747-61 – reference: 23132820 - Stem Cells. 2013 Feb;31(2):317-26 |
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| SubjectTerms | Animals Biomarkers - metabolism Cell Self Renewal Germ Cells - metabolism Humans Integrin alpha6 - metabolism Protein Binding Stem Cells - metabolism |
| Title | The Role of Integrin α6 (CD49f) in Stem Cells: More than a Conserved Biomarker |
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