Human immunodeficiency virus-specific cytotoxic responses of seropositive individuals: distinct types of effector cells mediate killing of targets expressing gag and env proteins
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| Published in | Journal of Virology Vol. 63; no. 5; pp. 2270 - 2277 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
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American Society for Microbiology
01.05.1989
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| ISSN | 0022-538X 1098-5514 |
| DOI | 10.1128/jvi.63.5.2270-2277.1989 |
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| AbstractList | By using target cells that expressed isolated env, gag, p27nef, or p23vif molecules introduced by recombinant vaccinia viruses containing genes encoding these polypeptides, it was possible to identify env, gag, p27nef, and p23vif as cytolytic target antigens for freshly isolated blood cells from human immunodeficiency virus 1 (HIV-1) seropositive patients. Most of the patients tested (95%) manifested a specific cytotoxic activity against vaccinia virus-env-infected target cells. The env-specific cytotoxic activity was not restricted by the major histocompatibility complex and was not mediated by T lymphocytes, as shown by the absence of blocking effect with an anti-CD3 monoclonal antibody and by the inefficiency of CD3+, CD8+, or CD4+ and CD8+ depletion to reduce the cytotoxic activity against the env-expressing target cells. In the same conditions, the cytotoxic activity specific for gag was abrogated and gag major histocompatibility complex-restricted cytotoxic T lymphocytes were detected in 85% of the subjects tested. Therefore, in a HIV-1 seropositive subject, distinct types of effector cells mediate the lysis of target cells expressing gag and env proteins. By using target cells that expressed isolated env, gag, p27 super(nef), or p23 super(vif) molecules introduced by recombinant vaccinia viruses containing genes encoding these polypeptides, it was possible to identify env, gag, p27 super(nef), and p23 super(vif) as cytolytic target antigens for freshly isolated blood cells from human immunodeficiency virus 1 (HIV-1) seropositive patients. Most of the patients tested (95%) manifested a specific cytotoxic activity against vaccinia virus-env-infected target cells. The env-specific cytotoxic activity was not restricted by the major histocompatibility complex and was not mediated by T lymphocytes, as shown by the absence of blocking effect with an anti-CD3 monoclonal antibody and by the inefficiency of CD3 super(+), CD8 super(+), or CD4 super(+) and CD8 super(+) depletion to reduce the cytotoxic activity against the env-expressing target cells. By using target cells that expressed isolated env, gag, p27nef, or p23vif molecules introduced by recombinant vaccinia viruses containing genes encoding these polypeptides, it was possible to identify env, gag, p27nef, and p23vif as cytolytic target antigens for freshly isolated blood cells from human immunodeficiency virus 1 (HIV-1) seropositive patients. Most of the patients tested (95%) manifested a specific cytotoxic activity against vaccinia virus-env-infected target cells. The env-specific cytotoxic activity was not restricted by the major histocompatibility complex and was not mediated by T lymphocytes, as shown by the absence of blocking effect with an anti-CD3 monoclonal antibody and by the inefficiency of CD3+, CD8+, or CD4+ and CD8+ depletion to reduce the cytotoxic activity against the env-expressing target cells. In the same conditions, the cytotoxic activity specific for gag was abrogated and gag major histocompatibility complex-restricted cytotoxic T lymphocytes were detected in 85% of the subjects tested. Therefore, in a HIV-1 seropositive subject, distinct types of effector cells mediate the lysis of target cells expressing gag and env proteins.By using target cells that expressed isolated env, gag, p27nef, or p23vif molecules introduced by recombinant vaccinia viruses containing genes encoding these polypeptides, it was possible to identify env, gag, p27nef, and p23vif as cytolytic target antigens for freshly isolated blood cells from human immunodeficiency virus 1 (HIV-1) seropositive patients. Most of the patients tested (95%) manifested a specific cytotoxic activity against vaccinia virus-env-infected target cells. The env-specific cytotoxic activity was not restricted by the major histocompatibility complex and was not mediated by T lymphocytes, as shown by the absence of blocking effect with an anti-CD3 monoclonal antibody and by the inefficiency of CD3+, CD8+, or CD4+ and CD8+ depletion to reduce the cytotoxic activity against the env-expressing target cells. In the same conditions, the cytotoxic activity specific for gag was abrogated and gag major histocompatibility complex-restricted cytotoxic T lymphocytes were detected in 85% of the subjects tested. Therefore, in a HIV-1 seropositive subject, distinct types of effector cells mediate the lysis of target cells expressing gag and env proteins. Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology. For an alternate route to JVI .asm.org, visit: JVI |
| Author | L Montagnier M P Kieny J J Fournel O Lopez Y Riviere P Sansonetti B Guy F Tanneau-Salvadori A Regnault |
| AuthorAffiliation | Viral Oncology Unit, Institut Pasteur, Paris, France |
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| Keywords | Human Cytolysis Immunopathology Seropositivity HIV-1 virus Cytotoxicity test Retroviridae Cytotoxicity AIDS Complement Hemopathy Monoclonal antibody Infection Virus Proteins Viral disease T-Lymphocyte Lysis Serum Human immunodeficiency virus Target cell |
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Mendeley... By using target cells that expressed isolated env, gag, p27nef, or p23vif molecules introduced by recombinant vaccinia viruses containing genes encoding these... By using target cells that expressed isolated env, gag, p27 super(nef), or p23 super(vif) molecules introduced by recombinant vaccinia viruses containing genes... |
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| SubjectTerms | Antibodies, Monoclonal Antigens, Differentiation, T-Lymphocyte - immunology Biological and medical sciences CD3 Complex CD8 Antigens Cytotoxicity, Immunologic Fundamental and applied biological sciences. Psychology Gene Products, gag HIV Seropositivity - immunology human immunodeficiency virus Humans Immunity, Cellular In Vitro Techniques Major Histocompatibility Complex Microbiology Receptors, Antigen, T-Cell - immunology Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains Retroviridae Proteins - immunology T-Lymphocytes - classification T-Lymphocytes - immunology Viral Envelope Proteins - immunology Virology |
| Title | Human immunodeficiency virus-specific cytotoxic responses of seropositive individuals: distinct types of effector cells mediate killing of targets expressing gag and env proteins |
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