Oxidized Phospholipids, Lipoprotein(a), Lipoprotein-Associated Phospholipase A2 Activity, and 10-Year Cardiovascular Outcomes: Prospective Results From the Bruneck Study

• Published in: Arteriosclerosis, thrombosis, and vascular biology Vol. 27; no. 8; pp. 1788 - 1795
• Main Authors: Kiechl, Stefan, Willeit, Johann, Mayr, Manuel, Viehweider, Brigitte, Oberhollenzer, Martin, Kronenberg, Florian, Wiedermann, Christian J., Oberthaler, Sabine, Xu, Qingbo, Witztum, Joseph L., Tsimikas, Sotirios
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Heart Association, Inc 01.08.2007; Hagerstown, MD Lippincott
• Subjects: 1-Alkyl-2-acetylglycerophosphocholine Esterase - blood; 1-Alkyl-2-acetylglycerophosphocholine Esterase - metabolism; Age Factors; Aged; Apolipoprotein B-100 - blood; Apolipoprotein B-100 - metabolism; Atherosclerosis (general aspects, experimental research); Atherosclerosis - diagnosis; Atherosclerosis - epidemiology; Biological and medical sciences; Biomarkers - blood; Blood and lymphatic vessels; Cardiology. Vascular system; Coronary Artery Disease - enzymology; Coronary Artery Disease - epidemiology; Coronary Artery Disease - physiopathology; Disease Progression; Diseases of the cardiovascular system; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Female; Fundamental and applied biological sciences. Psychology; General aspects; Humans; Male; Medical sciences; Middle Aged; Phospholipases A2; Phospholipids - blood; Phospholipids - metabolism; Population Surveillance; Predictive Value of Tests; Probability; Prognosis; Proportional Hazards Models; Prospective Studies; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Risk Factors; Sensitivity and Specificity; Severity of Illness Index; Sex Factors; Survival Analysis; Vertebrates: cardiovascular system; Prognosis; Enzyme; Phospholipid; Cardiovascular disease; Esterases; Phospholipase A; lipoprotein-associated phospholipase A2; Lipoprotein a; Carboxylic ester hydrolases; lipoprotein (a); Vascular disease; Atherosclerosis; Hydrolases; Oxidation; oxidized phospholipids; lipoproteins

BACKGROUND—Oxidized phospholipids (OxPL) circulate on apolipoprotein B-100 particles (OxPL/apoB), and primarily on Lp(a) lipoprotein (a) [Lp(a)]. The relationship of OxPL/apoB levels to future cardiovascular events is not known. METHODS AND RESULTS—The Bruneck study is a prospective population-based...