Coexistence of Light Chain and Transthyretin Cardiac Amyloidosis

Although most patients with cardiac amyloidosis are diagnosed with either light chain (AL) or transthyretin (ATTR) disease, coexisting amyloid subtypes can occur. We present three cases of coexisting AL and ATTR cardiac amyloidosis and demonstrate the importance of clinical history and endomyocardia...

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Published inJACC. Case reports Vol. 29; no. 7; p. 102285
Main Authors Gami, Abhishek, Woller, John, Scheel, Paul, Ali, Syed Abbas, Huff, Carol Ann, Steenbergen, Charles, Halushka, Marc, Sharma, Kavita, Polydefkis, Michael, Vaishnav, Joban
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 03.04.2024
Elsevier
Subjects
cardiac amyloidosis
Case Report
endomyocardial biopsy
light chain
transthyretin
MM
NT-pro-BNP
transthyretin
ATTR-CM
cardiac amyloidosis
endomyocardial biopsy
light chain
AL-CM
HFpEF
HF
LVH
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Abstract Although most patients with cardiac amyloidosis are diagnosed with either light chain (AL) or transthyretin (ATTR) disease, coexisting amyloid subtypes can occur. We present three cases of coexisting AL and ATTR cardiac amyloidosis and demonstrate the importance of clinical history and endomyocardial biopsy in diagnosis of this rare entity. [Display omitted]
AbstractList Although most patients with cardiac amyloidosis are diagnosed with either light chain (AL) or transthyretin (ATTR) disease, coexisting amyloid subtypes can occur. We present three cases of coexisting AL and ATTR cardiac amyloidosis and demonstrate the importance of clinical history and endomyocardial biopsy in diagnosis of this rare entity.
Although most patients with cardiac amyloidosis are diagnosed with either light chain (AL) or transthyretin (ATTR) disease, coexisting amyloid subtypes can occur. We present three cases of coexisting AL and ATTR cardiac amyloidosis and demonstrate the importance of clinical history and endomyocardial biopsy in diagnosis of this rare entity. [Display omitted]
ArticleNumber 102285
Author Ali, Syed Abbas
Steenbergen, Charles
Scheel, Paul
Sharma, Kavita
Huff, Carol Ann
Vaishnav, Joban
Halushka, Marc
Gami, Abhishek
Polydefkis, Michael
Woller, John
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  organization: Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
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10.1161/CIRCULATIONAHA.116.021612
10.1056/NEJMoa1805689
10.1007/s10741-021-10080-2
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Keywords MM
NT-pro-BNP
transthyretin
ATTR-CM
cardiac amyloidosis
endomyocardial biopsy
light chain
AL-CM
HFpEF
HF
LVH
Language English
License This is an open access article under the CC BY-NC-ND license.
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SubjectTerms cardiac amyloidosis
Case Report
endomyocardial biopsy
light chain
transthyretin
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Title Coexistence of Light Chain and Transthyretin Cardiac Amyloidosis
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