Potential role of APOE ɛ4 allele as a modifier for the association of BDNF Val66Met polymorphisms and cognitive impairment in community-dwelling older adults

• Published in: Frontiers in aging neuroscience Vol. 16; p. 1330193
• Main Authors: Ji, Shaozhen, Kang, Jia, Han, Chao, Xu, Xitong, Chen, Meijie, Chen, Jie, Chhetri, Jagadish K, Pan, Jing, Chan, Piu
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 05.02.2024; Frontiers Media S.A
• Subjects: Aging; Aging Neuroscience; Alleles; APOE ε4; Apolipoprotein E; BDNF Val66Met; Brain-derived neurotrophic factor; Cognitive ability; cognitive impairment; Confounding (Statistics); Dementia disorders; Disease; Genotype & phenotype; Health risk assessment; Memory; modify; older adults; Older people; Polymorphism; Regression analysis; Beijing China; China; APOE ε4; older adults; modify; BDNF Val66Met; cognitive impairment

To determine whether the brain-derived neurotrophic factor ( ) Val66Met polymorphism is associated with cognitive impairment (CI) in community-dwelling Chinese older adults, and to investigate whether this relationship is modified by the Apolipoprotein E ( ) ɛ4 allele. The study is a secondary analy...