Potential role of APOE ɛ4 allele as a modifier for the association of BDNF Val66Met polymorphisms and cognitive impairment in community-dwelling older adults
To determine whether the brain-derived neurotrophic factor ( ) Val66Met polymorphism is associated with cognitive impairment (CI) in community-dwelling Chinese older adults, and to investigate whether this relationship is modified by the Apolipoprotein E ( ) ɛ4 allele. The study is a secondary analy...
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| Published in | Frontiers in aging neuroscience Vol. 16; p. 1330193 |
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| Language | English |
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| Abstract | To determine whether the brain-derived neurotrophic factor (
) Val66Met polymorphism is associated with cognitive impairment (CI) in community-dwelling Chinese older adults, and to investigate whether this relationship is modified by the Apolipoprotein E (
) ɛ4 allele.
The study is a secondary analysis of 703 participants aged ≥60 years randomly enrolled from the Beijing Longitudinal Study of Aging II prospective cohort. The education-adjusted Mini-Mental State Examination and the Clinical Dementia Rating Scale were used to measure the cognitive performance of the subjects. The main effects and interactions (additive and multiplicative) of the
Met and the
ε4 alleles on CI were estimated by logistic regression models.
In total, 84 out of 703 older adults aged ≥60 years old had CI. No significant difference was observed in the risk of CI between participants with the
Met allele and that of subjects without the
Met allele (
= 0.213;
= 0.164). Individuals carrying both the
Met and
ε4 alleles had an almost 1.5-fold increased odds of CI compared with carriers of the
Met allele but without the
ε4 allele. The additive association indicated a positive interaction of both
Met and
ε4 alleles with wide CIs (
= 0.021;
= 0.018).
The results suggest that the
ε4 allele may be a potential modifier for the association of the
Val66Met polymorphism with CI in community-dwelling older adults. |
|---|---|
| AbstractList | To determine whether the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with cognitive impairment (CI) in community-dwelling Chinese older adults, and to investigate whether this relationship is modified by the Apolipoprotein E (APOE) ɛ4 allele.ObjectiveTo determine whether the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with cognitive impairment (CI) in community-dwelling Chinese older adults, and to investigate whether this relationship is modified by the Apolipoprotein E (APOE) ɛ4 allele.The study is a secondary analysis of 703 participants aged ≥60 years randomly enrolled from the Beijing Longitudinal Study of Aging II prospective cohort. The education-adjusted Mini-Mental State Examination and the Clinical Dementia Rating Scale were used to measure the cognitive performance of the subjects. The main effects and interactions (additive and multiplicative) of the BDNF Met and the APOE ε4 alleles on CI were estimated by logistic regression models.MethodsThe study is a secondary analysis of 703 participants aged ≥60 years randomly enrolled from the Beijing Longitudinal Study of Aging II prospective cohort. The education-adjusted Mini-Mental State Examination and the Clinical Dementia Rating Scale were used to measure the cognitive performance of the subjects. The main effects and interactions (additive and multiplicative) of the BDNF Met and the APOE ε4 alleles on CI were estimated by logistic regression models.In total, 84 out of 703 older adults aged ≥60 years old had CI. No significant difference was observed in the risk of CI between participants with the BDNF Met allele and that of subjects without the BDNF Met allele (p = 0.213; p = 0.164). Individuals carrying both the BDNF Met and APOE ε4 alleles had an almost 1.5-fold increased odds of CI compared with carriers of the BDNF Met allele but without the APOE ε4 allele. The additive association indicated a positive interaction of both BDNF Met and APOE ε4 alleles with wide CIs (p = 0.021; p = 0.018).ResultsIn total, 84 out of 703 older adults aged ≥60 years old had CI. No significant difference was observed in the risk of CI between participants with the BDNF Met allele and that of subjects without the BDNF Met allele (p = 0.213; p = 0.164). Individuals carrying both the BDNF Met and APOE ε4 alleles had an almost 1.5-fold increased odds of CI compared with carriers of the BDNF Met allele but without the APOE ε4 allele. The additive association indicated a positive interaction of both BDNF Met and APOE ε4 alleles with wide CIs (p = 0.021; p = 0.018).The results suggest that the APOE ε4 allele may be a potential modifier for the association of the BDNF Val66Met polymorphism with CI in community-dwelling older adults.ConclusionThe results suggest that the APOE ε4 allele may be a potential modifier for the association of the BDNF Val66Met polymorphism with CI in community-dwelling older adults. To determine whether the brain-derived neurotrophic factor ( ) Val66Met polymorphism is associated with cognitive impairment (CI) in community-dwelling Chinese older adults, and to investigate whether this relationship is modified by the Apolipoprotein E ( ) ɛ4 allele. The study is a secondary analysis of 703 participants aged ≥60 years randomly enrolled from the Beijing Longitudinal Study of Aging II prospective cohort. The education-adjusted Mini-Mental State Examination and the Clinical Dementia Rating Scale were used to measure the cognitive performance of the subjects. The main effects and interactions (additive and multiplicative) of the Met and the ε4 alleles on CI were estimated by logistic regression models. In total, 84 out of 703 older adults aged ≥60 years old had CI. No significant difference was observed in the risk of CI between participants with the Met allele and that of subjects without the Met allele ( = 0.213; = 0.164). Individuals carrying both the Met and ε4 alleles had an almost 1.5-fold increased odds of CI compared with carriers of the Met allele but without the ε4 allele. The additive association indicated a positive interaction of both Met and ε4 alleles with wide CIs ( = 0.021; = 0.018). The results suggest that the ε4 allele may be a potential modifier for the association of the Val66Met polymorphism with CI in community-dwelling older adults. ObjectiveTo determine whether the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with cognitive impairment (CI) in community-dwelling Chinese older adults, and to investigate whether this relationship is modified by the Apolipoprotein E (APOE) ɛ4 allele.MethodsThe study is a secondary analysis of 703 participants aged ≥60 years randomly enrolled from the Beijing Longitudinal Study of Aging II prospective cohort. The education-adjusted Mini-Mental State Examination and the Clinical Dementia Rating Scale were used to measure the cognitive performance of the subjects. The main effects and interactions (additive and multiplicative) of the BDNF Met and the APOE ε4 alleles on CI were estimated by logistic regression models.ResultsIn total, 84 out of 703 older adults aged ≥60 years old had CI. No significant difference was observed in the risk of CI between participants with the BDNF Met allele and that of subjects without the BDNF Met allele (p = 0.213; p = 0.164). Individuals carrying both the BDNF Met and APOE ε4 alleles had an almost 1.5-fold increased odds of CI compared with carriers of the BDNF Met allele but without the APOE ε4 allele. The additive association indicated a positive interaction of both BDNF Met and APOE ε4 alleles with wide CIs (p = 0.021; p = 0.018).ConclusionThe results suggest that the APOE ε4 allele may be a potential modifier for the association of the BDNF Val66Met polymorphism with CI in community-dwelling older adults. To determinate whether brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with cognitive impairment (CI) in the communitydwelling Chinese aged adults, and investigate whether this relationship is modified by Apolipoprotein E (APOE) ɛ4 allele.The study is a second analysis for 703 participants aged ≥60 years randomly enrolled from the Beijing Longitudinal Study of Aging II prospective cohort. Educationadjusted Mini-Mental State Examination and the Clinical Dementia Rating Scale measure cognitive performance of the subjects. Main effects and interactions (additive, multiplicative) of BDNF Met allele and APOE ε4 allele for CI were estimated by logistic regression models. Results 84 out of 703 older adults aged ≥60 years old were CI. No significant difference was observed in CI risk of participants with BDNF Met allele and that of subjects without BDNF Met allele (P = 0.213; P = 0.164). The individuals carrying both BDNF Met allele and APOE ε4 showed an almost 1.5-fold higher Odds for CI compared carriers of BDNF Met allele not APOE ε4. The additive association indicated a positive interaction of both BNDF Met and APOE ε4 alleles with broad CIs (P = 0.021; P = 0.018).The results suggested that APOE ε4 allele might be a potential modifier for the association of BDNF Val66Met polymorphism and CI among community dwelling older adults. |
| Author | Ji, Shaozhen Pan, Jing Kang, Jia Chhetri, Jagadish K Chan, Piu Han, Chao Chen, Jie Chen, Meijie Xu, Xitong |
| AuthorAffiliation | 2 Department of Neurology, The Second Affiliated Hospital of Inner Mongolia Medical University , Hohhot , China 5 Department of Geriatrics, Shenzhen Hospital, Peking University , Shenzhen , China 6 Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital of Capital Medical University , Beijing , China 1 Department of Neurology, Dongfang Hospital, Beijing University of Chinese Medicine , Beijing , China 3 National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital of Capital Medical University , Beijing , China 4 Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University , Jinan , China |
| AuthorAffiliation_xml | – name: 6 Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital of Capital Medical University , Beijing , China – name: 5 Department of Geriatrics, Shenzhen Hospital, Peking University , Shenzhen , China – name: 3 National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital of Capital Medical University , Beijing , China – name: 4 Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University , Jinan , China – name: 1 Department of Neurology, Dongfang Hospital, Beijing University of Chinese Medicine , Beijing , China – name: 2 Department of Neurology, The Second Affiliated Hospital of Inner Mongolia Medical University , Hohhot , China |
| Author_xml | – sequence: 1 givenname: Shaozhen surname: Ji fullname: Ji, Shaozhen – sequence: 2 givenname: Jia surname: Kang fullname: Kang, Jia – sequence: 3 givenname: Chao surname: Han fullname: Han, Chao – sequence: 4 givenname: Xitong surname: Xu fullname: Xu, Xitong – sequence: 5 givenname: Meijie surname: Chen fullname: Chen, Meijie – sequence: 6 givenname: Jie surname: Chen fullname: Chen, Jie – sequence: 7 givenname: Jagadish K surname: Chhetri fullname: Chhetri, Jagadish K – sequence: 8 givenname: Jing surname: Pan fullname: Pan, Jing – sequence: 9 givenname: Piu surname: Chan fullname: Chan, Piu |
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| CitedBy_id | crossref_primary_10_1016_j_tins_2024_04_004 |
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| Keywords | APOE ε4 older adults modify BDNF Val66Met cognitive impairment |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 These authors have contributed equally to this work Edited by: Boon-Seng Wong, Singapore Institute of Technology, Singapore Reviewed by: Qingwei Ruan, Huadong Hospital, Fudan University, China; Jolanta Dorszewska, Poznan University of Medical Sciences, Poland |
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| Snippet | To determine whether the brain-derived neurotrophic factor (
) Val66Met polymorphism is associated with cognitive impairment (CI) in community-dwelling Chinese... To determinate whether brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with cognitive impairment (CI) in the communitydwelling... To determine whether the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with cognitive impairment (CI) in community-dwelling... ObjectiveTo determine whether the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with cognitive impairment (CI) in... |
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| SubjectTerms | Aging Aging Neuroscience Alleles APOE ε4 Apolipoprotein E BDNF Val66Met Brain-derived neurotrophic factor Cognitive ability cognitive impairment Confounding (Statistics) Dementia disorders Disease Genotype & phenotype Health risk assessment Memory modify older adults Older people Polymorphism Regression analysis |
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| Title | Potential role of APOE ɛ4 allele as a modifier for the association of BDNF Val66Met polymorphisms and cognitive impairment in community-dwelling older adults |
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