Alveolar and lung interstitial macrophages: Definitions, functions, and roles in lung fibrosis

• Published in: Journal of leukocyte biology Vol. 110; no. 1; pp. 107 - 114
• Main Authors: Shi, Ting, Denney, Laura, An, Huazhang, Ho, Ling‐Pei, Zheng, Yuejuan
• Format: Journal Article
• Language: English
• Published: England 01.07.2021
• Subjects: Animals; asthma; Cellular Microenvironment; Disease Susceptibility; fibrosis; Homeostasis; Humans; Immunity, Innate; lung; Lung - immunology; Lung - metabolism; Lung - pathology; Macrophages, Alveolar - immunology; Macrophages, Alveolar - metabolism; Macrophages, Alveolar - pathology; Mϕs; Pulmonary Alveoli - immunology; Pulmonary Alveoli - metabolism; Pulmonary Alveoli - pathology; Pulmonary Fibrosis - etiology; Pulmonary Fibrosis - metabolism; Pulmonary Fibrosis - pathology; lung; Mϕs; asthma; fibrosis

Mϕs are the main innate immune cells in the lung at homeostasis, with important roles in host defence and immune modulation. Alveolar Mϕs (AMs) and interstitial Mϕs (IMs) are the two lung Mϕ subsets, so called according to the sites they reside in. These subsets are also defined by their origins and...