Pharmacokinetic evaluation of oral itraconazole for antifungal prophylaxis in children

• Published in: Clinical and experimental pharmacology & physiology Vol. 44; no. 11; pp. 1083 - 1088
• Main Authors: Allegra, Sarah, Fatiguso, Giovanna, De Francia, Silvia, Favata, Fabio, Pirro, Elisa, Carcieri, Chiara, De Nicolò, Amedeo, Cusato, Jessica, Di Perri, Giovanni, D'Avolio, Antonio
• Format: Journal Article
• Language: English
• Published: Australia Wiley Subscription Services, Inc 01.11.2017
• Subjects: Administration, Oral; antifungal; Antifungal Agents - administration & dosage; Antifungal Agents - blood; Antifungal Agents - pharmacokinetics; Antifungal Agents - pharmacology; Bioavailability; Child; Child, Preschool; Children; Chromatography; Continuity (mathematics); Drug dosages; Female; Fungicides; HPLC; Humans; invasive fungal infections; Itraconazole; Itraconazole - administration & dosage; Itraconazole - blood; Itraconazole - pharmacokinetics; Itraconazole - pharmacology; Male; Minority & ethnic groups; Monitoring; Mycoses - prevention & control; paediatrics; Pediatrics; Pharmacokinetics; Pharmacology; Prophylaxis; Regression analysis; Regression models; therapeutic drug monitoring; Triazoles; Variables; paediatrics; antifungal; itraconazole; invasive fungal infections; HPLC; therapeutic drug monitoring

Summary Itraconazole is a first‐generation triazole agent with an extended spectrum of activity; it is licensed in adults for superficial and systemic fungal infections; no recommendation has been yet established for use in children patients. Its variable and unpredictable oral bioavailability make...