Pharmacokinetic–Pharmacodynamic Cutoff Values for Doxycycline in Pigs to Support the Establishment of Clinical Breakpoints for Antimicrobial Susceptibility Testing

• Published in: Journal of veterinary pharmacology and therapeutics Vol. 48; no. 4; pp. 300 - 317
• Main Authors: Toutain, Pierre‐Louis, Bousquet‐Melou, Alain, Ferran, Aude A., Roques, Béatrice B., Castillo, Jérôme R. E., Lees, Peter, Croubels, Siska, Bousquet, Eric, Pelligand, Ludovic
• Format: Journal Article
• Language: English
• Published: England Wiley-Blackwell 01.07.2025; John Wiley and Sons Inc
• Subjects: Animals; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - blood; Anti-Bacterial Agents - pharmacokinetics; Anti-Bacterial Agents - pharmacology; Antimicrobial susceptibility testing; Biological Availability; doxycycline; Doxycycline - administration & dosage; Doxycycline - blood; Doxycycline - pharmacokinetics; Doxycycline - pharmacology; Half-Life; Life Sciences; Microbial Sensitivity Tests - veterinary; Models, Biological; Original; Pharmaceutical sciences; pharmacokinetics; Pharmacology; pigs; PK/PD cutoff; Swine - blood; Swine - metabolism; Antimicrobial susceptibility testing; pharmacokinetics; pigs; doxycycline; PK/PD cutoff

ABSTRACT This meta‐analysis provides a population model of doxycycline (DOXY) disposition in pigs for computation of PK/PD cutoff values corresponding to differing modalities of DOXY administration orally in pigs. This analysis enables establishment of specific clinical breakpoints for the developme...