On Broken Ne(c)ks and Broken DNA: The Role of Human NEKs in the DNA Damage Response

• Published in: Cells (Basel, Switzerland) Vol. 10; no. 3; p. 507
• Main Authors: Pavan, Isadora Carolina Betim, Peres de Oliveira, Andressa, Dias, Pedro Rafael Firmino, Basei, Fernanda Luisa, Issayama, Luidy Kazuo, Ferezin, Camila de Castro, Silva, Fernando Riback, Rodrigues de Oliveira, Ana Luisa, Alves Dos Reis Moura, Lívia, Martins, Mariana Bonjiorno, Simabuco, Fernando Moreira, Kobarg, Jörg
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 27.02.2021; MDPI
• Subjects: Apoptosis; Ataxia telangiectasia; Ataxia telangiectasia mutated protein; Cell activation; Cell cycle; Cell division; Chromosomes; Cilia; Cyclin-dependent kinases; Deoxyribonucleic acid; DNA; DNA damage; DNA Damage - genetics; DNA damage response; DNA repair; DNA Repair - genetics; DNA-dependent protein kinase; Double-strand break repair; Gene expression; Genomes; Homology; Humans; kinase; Kinases; Metabolism; Mitosis; Nek1 protein; Non-homologous end joining; p53 Protein; Phosphorylation; Protein interaction; protein kinase; Proteins; Review; kinase; DNA damage response; cell cycle; protein kinase

NIMA-related kinases, or NEKs, are a family of Ser/Thr protein kinases involved in cell cycle and mitosis, centrosome disjunction, primary cilia functions, and DNA damage responses among other biological functional contexts in vertebrate cells. In human cells, there are 11 members, termed NEK1 to 11...