Insensitivity of the chicken embryo to the ototoxicity of aminoglycoside antibiotics and a loop diuretic

• Published in: Toxicologic pathology Vol. 22; no. 1; p. 10
• Main Authors: Fikes, J D, Render, J A, Reed, W M, Bursian, S, Poppenga, R H, Sleight, S D
• Format: Journal Article
• Language: English
• Published: United States 01.01.1994
• Subjects: Animals; Anti-Bacterial Agents - toxicity; Chick Embryo; Cochlea - pathology; Diuretics - toxicity; Ear Diseases - chemically induced; Ear Diseases - pathology; Ethacrynic Acid - toxicity; Gentamicins - toxicity; Hair Cells, Auditory - drug effects; Kanamycin - toxicity; Kidney - pathology; Streptomycin - toxicity

Guinea pigs are routinely used in the histological evaluation of the cochlea as a method of testing for ototoxicity, but the procedures are very time-consuming. Because the avian cochlea is easier to examine and newly hatched chicks are sensitive to the ototoxic effects of gentamicin, birds may be u...