Supplementation of scopoletin improves insulin sensitivity by attenuating the derangements of insulin signaling through AMPK

• Published in: Molecular and cellular biochemistry Vol. 453; no. 1-2; pp. 65 - 78
• Main Authors: Kalpana, Kalaivanan, Sathiya Priya, Chandrasekaran, Dipti, Nanda, Vidhya, Ramachandran, Anuradha, Carani Venkatraman
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.03.2019; Springer; Springer Nature B.V
• Subjects: 1-Phosphatidylinositol 3-kinase; Activated carbon; AKT protein; Antioxidants; Antioxidants (Nutrients); Biochemistry; Biomedical and Life Sciences; Carbonyl compounds; Carbonyls; Cardiology; Catalase; Coumarin; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Dietary supplements; EDTA; Fructose; Glucose; Glucose metabolism; Glutathione; Glutathione peroxidase; High fat diet; Inositol; Insulin; Insulin receptor substrate 1; Kinases; Life Sciences; Lipids; Medical Biochemistry; Membrane lipids; Metabolism; Oncology; Oxidative stress; Pancreas; Peroxidase; Phenolic compounds; Phenols; Phosphorylation; Plant lipids; Protein kinases; Proteins; Rats; Rodents; Signaling; Substrates; Superoxide dismutase; Superoxides; Type 2 diabetes; Insulin resistance; AMPK; AICAR; Scopoletin

Scopoletin (SPL), a phenolic coumarin, is reported to regulate glucose metabolism. This study is initiated to substantiate the action of SPL on the regulation of insulin signaling in insulin resistant RIN5f cells and high fat, high fructose diet (HFFD)-fed rat model. Adult male Sprague Dawley rats w...