Fate of induced pluripotent stem cells following transplantation to murine seminiferous tubules

• Published in: Human molecular genetics Vol. 23; no. 12; pp. 3071 - 3084
• Main Authors: Durruthy Durruthy, Jens, Ramathal, Cyril, Sukhwani, Meena, Fang, Fang, Cui, Jun, Orwig, Kyle E, Reijo Pera, Renee A
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 15.06.2014
• Subjects: Animals; Cell Differentiation; Cell Line; Cellular Reprogramming; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation; Humans; Induced Pluripotent Stem Cells - metabolism; Induced Pluripotent Stem Cells - transplantation; Male; Mice; Mice, Nude; Seminiferous Tubules - metabolism; Spermatozoa - cytology; Spermatozoa - physiology; Transplantation, Heterologous - methods

Studies of human germ cell development are limited in large part by inaccessibility of germ cells during development. Moreover, although several studies have reported differentiation of mouse and human germ cells from pluripotent stem cells (PSCs) in vitro, differentiation of human germ cells from P...