Novel microRNA correlations in the severely injured

• Published in: Surgery Vol. 156; no. 4; pp. 834 - 841
• Main Authors: Uhlich, Rindi M., BS, Konie, Jared A., MD, Davis, J. Wade, PhD, Misfeldt, Michael L., PhD, Nelson, Christopher, MD, Calaluce, Robert, MD, Barnes, Stephen L., MD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2014
• Subjects: Adult; Aged; Biomarkers - metabolism; Blood Transfusion; Case-Control Studies; Female; Gene Expression Profiling; Genetic Markers; Humans; Injury Severity Score; Linear Models; Male; MicroRNAs - blood; Middle Aged; Pilot Projects; Prospective Studies; Sequence Analysis, RNA; Shock, Hemorrhagic - blood; Shock, Hemorrhagic - etiology; Shock, Hemorrhagic - genetics; Shock, Hemorrhagic - therapy; Signal Transduction; Surgery; Toll-Like Receptor 3 - metabolism; Toll-Like Receptor 4 - metabolism; Wounds and Injuries - blood; Wounds and Injuries - complications; Wounds and Injuries - genetics; Wounds and Injuries - therapy

Purpose Severe injury initiates an inflammatory response that can perpetuate immunological dysfunction, uncontrolled inflammation, and subsequent multisystem organ failure. MicroRNAs (miRNAs) have recently been identified as regulators of this inflammatory response. Our study sought to identify the...