Evaluation of Novel Imidazotetrazine Analogues Designed to Overcome Temozolomide Resistance and Glioblastoma Regrowth - Ramirez, Yulian P.; Mladek, Ann C.; Phillips, Roger M.; Gynther, Mikko; Rautio, Jarkko; Ross, Alonzo H.; Wheelhouse, Richard T.; Sakaria, Jann N. (Molecular cancer therapeutics, 2015)
Keywords: Aniline Compounds - administration & dosage; Aniline Compounds - chemical synthesis; Aniline Compounds - pharmacokinetics; Animals; Antineoplastic Agents, Alkylating - administration & dosage; Antineoplastic Agents, Alkylating - chemical synthesis; Antineoplastic Agents, Alkylating - pharmacokinetics; Ataxia Telangiectasia Mutated Proteins - metabolism; Brain Neoplasms - drug therapy; Brain Neoplasms - metabolism; Cell Cycle - drug effects; Cell Line, Tumor; Dacarbazine - administration & dosage; Dacarbazine - analogs & derivatives; Dacarbazine - pharmacokinetics; DNA Damage - drug effects; DNA Modification Methylases - metabolism; DNA Repair Enzymes - metabolism; Drug Resistance, Neoplasm - drug effects; Fanconi Anemia Complementation Group D2 Protein - metabolism; Gene Expression Regulation, Neoplastic - drug effects; Glioblastoma - drug therapy; Glioblastoma - metabolism; Heterocyclic Compounds, 2-Ring - administration & dosage; Heterocyclic Compounds, 2-Ring - chemical synthesis; Heterocyclic Compounds, 2-Ring - pharmacokinetics; Humans; Mice; Mice, Inbred C57BL; Neoplasm Recurrence, Local - drug therapy; Neoplasm Recurrence, Local - metabolism; Temozolomide; Tumor Suppressor Proteins - metabolism; Xenograft Model Antitumor Assays