The Behavioral and Neurochemical Effects of a Novel d-Amino Acid Oxidase Inhibitor Compound 8 [4 H-Thieno [3,2-b]pyrrole-5-carboxylic Acid] and d-Serine

• Published in: The Journal of pharmacology and experimental therapeutics Vol. 328; no. 3; pp. 921 - 930
• Main Authors: Smith, Sean M., Uslaner, Jason M., Yao, Lihang, Mullins, Chadwick M., Surles, Nathan O., Huszar, Sarah L., McNaughton, Caitlyn H., Pascarella, Danette M., Kandebo, Monika, Hinchliffe, Richard M., Sparey, Tim, Brandon, Nicholas J., Jones, Brian, Venkatraman, Shankar, Young, Mary Beth, Sachs, Nancy, Jacobson, Marlene A., Hutson, Peter H.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2009; American Society for Pharmacology and Experimental Therapeutics
• Subjects: Aged; Animals; D-Amino-Acid Oxidase - pharmacology; Dizocilpine Maleate - pharmacology; Habituation, Psychophysiologic; Humans; Male; Models, Molecular; Pyrroles - pharmacology; Rats; Rats, Wistar; Recognition, Psychology - drug effects; Schizophrenia - blood; Schizophrenia - cerebrospinal fluid; Serine - blood; Serine - cerebrospinal fluid; Serine - pharmacology; Thiophenes - chemistry; Thiophenes - pharmacology

Multiple studies indicate that N-methyl-d-aspartate (NMDA) receptor hypofunction underlies some of the deficits associated with schizophrenia. One approach for improving NMDA receptor function is to enhance occupancy of the glycine modulatory site on the NMDA receptor by increasing the availability...