Mapping the changed hubs and corresponding functional connectivity in idiopathic restless legs syndrome
The hubs of the brain network play a key role in integrating and transferring information between different functional modules. However, whether the changed pattern in functional network hubs contributes to the onset of leg discomfort symptoms in restless legs syndrome (RLS) patients remains unclear...
Saved in:
| Published in | Sleep medicine Vol. 45; pp. 132 - 139 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.05.2018
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1389-9457 1878-5506 1878-5506 |
| DOI | 10.1016/j.sleep.2017.12.016 |
Cover
| Abstract | The hubs of the brain network play a key role in integrating and transferring information between different functional modules. However, whether the changed pattern in functional network hubs contributes to the onset of leg discomfort symptoms in restless legs syndrome (RLS) patients remains unclear. Using resting-state functional magnetic resonance imaging (rs-fMRI) and graph theory methods, we investigated whether alterations of hubs can be detected in RLS.
First, we constructed the whole-brain voxelwise functional connectivity and calculated a functional connectivity strength (FCS) map in each of 16 drug-naive idiopathic RLS patients and 26 gender- and age-matched healthy control (HC) subjects. Next, a two-sample t test was applied to compare the FCS maps between HC and RLS patients, and to identify significant changes in FCS in RLS patients. To further elucidate the corresponding changes in the functional connectivity patterns of the aberrant hubs in RLS patients, whole-brain resting-state functional connectivity analyses for the hub areas were performed.
The hub analysis revealed decreased FCS in the cuneus, fusiform gyrus, paracentral lobe, and precuneus, and increased FCS in the superior frontal gyrus and thalamus in idiopathic drug-naive RLS patients. Subsequent functional connectivity analyses revealed decreased functional connectivity in sensorimotor and visual processing networks and increased functional connectivity in the affective cognitive network and cerebellar–thalamic circuit. Furthermore, the mean FCS value in the superior frontal gyrus was significantly correlated with Hamilton Anxiety Rating Scale scores in RLS patients, and the mean FCS value in the fusiform gyrus was significantly correlated with Hamilton Depression Rating Scale scores.
These findings may provide novel insight into the pathophysiology of RLS.
•The changed hubs of the brain and corresponding functional alterations in restless legs syndrome patients were investigated.•The hub analysis revealed decreased functional connectivity in sensorimotor and visual processing network.•And increased functional connectivity in the affective cognitive network and cerebellar-thalamic circuit. |
|---|---|
| AbstractList | The hubs of the brain network play a key role in integrating and transferring information between different functional modules. However, whether the changed pattern in functional network hubs contributes to the onset of leg discomfort symptoms in restless legs syndrome (RLS) patients remains unclear. Using resting-state functional magnetic resonance imaging (rs-fMRI) and graph theory methods, we investigated whether alterations of hubs can be detected in RLS.
First, we constructed the whole-brain voxelwise functional connectivity and calculated a functional connectivity strength (FCS) map in each of 16 drug-naive idiopathic RLS patients and 26 gender- and age-matched healthy control (HC) subjects. Next, a two-sample t test was applied to compare the FCS maps between HC and RLS patients, and to identify significant changes in FCS in RLS patients. To further elucidate the corresponding changes in the functional connectivity patterns of the aberrant hubs in RLS patients, whole-brain resting-state functional connectivity analyses for the hub areas were performed.
The hub analysis revealed decreased FCS in the cuneus, fusiform gyrus, paracentral lobe, and precuneus, and increased FCS in the superior frontal gyrus and thalamus in idiopathic drug-naive RLS patients. Subsequent functional connectivity analyses revealed decreased functional connectivity in sensorimotor and visual processing networks and increased functional connectivity in the affective cognitive network and cerebellar-thalamic circuit. Furthermore, the mean FCS value in the superior frontal gyrus was significantly correlated with Hamilton Anxiety Rating Scale scores in RLS patients, and the mean FCS value in the fusiform gyrus was significantly correlated with Hamilton Depression Rating Scale scores.
These findings may provide novel insight into the pathophysiology of RLS. The hubs of the brain network play a key role in integrating and transferring information between different functional modules. However, whether the changed pattern in functional network hubs contributes to the onset of leg discomfort symptoms in restless legs syndrome (RLS) patients remains unclear. Using resting-state functional magnetic resonance imaging (rs-fMRI) and graph theory methods, we investigated whether alterations of hubs can be detected in RLS. First, we constructed the whole-brain voxelwise functional connectivity and calculated a functional connectivity strength (FCS) map in each of 16 drug-naive idiopathic RLS patients and 26 gender- and age-matched healthy control (HC) subjects. Next, a two-sample t test was applied to compare the FCS maps between HC and RLS patients, and to identify significant changes in FCS in RLS patients. To further elucidate the corresponding changes in the functional connectivity patterns of the aberrant hubs in RLS patients, whole-brain resting-state functional connectivity analyses for the hub areas were performed. The hub analysis revealed decreased FCS in the cuneus, fusiform gyrus, paracentral lobe, and precuneus, and increased FCS in the superior frontal gyrus and thalamus in idiopathic drug-naive RLS patients. Subsequent functional connectivity analyses revealed decreased functional connectivity in sensorimotor and visual processing networks and increased functional connectivity in the affective cognitive network and cerebellar–thalamic circuit. Furthermore, the mean FCS value in the superior frontal gyrus was significantly correlated with Hamilton Anxiety Rating Scale scores in RLS patients, and the mean FCS value in the fusiform gyrus was significantly correlated with Hamilton Depression Rating Scale scores. These findings may provide novel insight into the pathophysiology of RLS. •The changed hubs of the brain and corresponding functional alterations in restless legs syndrome patients were investigated.•The hub analysis revealed decreased functional connectivity in sensorimotor and visual processing network.•And increased functional connectivity in the affective cognitive network and cerebellar-thalamic circuit. The hubs of the brain network play a key role in integrating and transferring information between different functional modules. However, whether the changed pattern in functional network hubs contributes to the onset of leg discomfort symptoms in restless legs syndrome (RLS) patients remains unclear. Using resting-state functional magnetic resonance imaging (rs-fMRI) and graph theory methods, we investigated whether alterations of hubs can be detected in RLS.OBJECTIVEThe hubs of the brain network play a key role in integrating and transferring information between different functional modules. However, whether the changed pattern in functional network hubs contributes to the onset of leg discomfort symptoms in restless legs syndrome (RLS) patients remains unclear. Using resting-state functional magnetic resonance imaging (rs-fMRI) and graph theory methods, we investigated whether alterations of hubs can be detected in RLS.First, we constructed the whole-brain voxelwise functional connectivity and calculated a functional connectivity strength (FCS) map in each of 16 drug-naive idiopathic RLS patients and 26 gender- and age-matched healthy control (HC) subjects. Next, a two-sample t test was applied to compare the FCS maps between HC and RLS patients, and to identify significant changes in FCS in RLS patients. To further elucidate the corresponding changes in the functional connectivity patterns of the aberrant hubs in RLS patients, whole-brain resting-state functional connectivity analyses for the hub areas were performed.METHODSFirst, we constructed the whole-brain voxelwise functional connectivity and calculated a functional connectivity strength (FCS) map in each of 16 drug-naive idiopathic RLS patients and 26 gender- and age-matched healthy control (HC) subjects. Next, a two-sample t test was applied to compare the FCS maps between HC and RLS patients, and to identify significant changes in FCS in RLS patients. To further elucidate the corresponding changes in the functional connectivity patterns of the aberrant hubs in RLS patients, whole-brain resting-state functional connectivity analyses for the hub areas were performed.The hub analysis revealed decreased FCS in the cuneus, fusiform gyrus, paracentral lobe, and precuneus, and increased FCS in the superior frontal gyrus and thalamus in idiopathic drug-naive RLS patients. Subsequent functional connectivity analyses revealed decreased functional connectivity in sensorimotor and visual processing networks and increased functional connectivity in the affective cognitive network and cerebellar-thalamic circuit. Furthermore, the mean FCS value in the superior frontal gyrus was significantly correlated with Hamilton Anxiety Rating Scale scores in RLS patients, and the mean FCS value in the fusiform gyrus was significantly correlated with Hamilton Depression Rating Scale scores.RESULTSThe hub analysis revealed decreased FCS in the cuneus, fusiform gyrus, paracentral lobe, and precuneus, and increased FCS in the superior frontal gyrus and thalamus in idiopathic drug-naive RLS patients. Subsequent functional connectivity analyses revealed decreased functional connectivity in sensorimotor and visual processing networks and increased functional connectivity in the affective cognitive network and cerebellar-thalamic circuit. Furthermore, the mean FCS value in the superior frontal gyrus was significantly correlated with Hamilton Anxiety Rating Scale scores in RLS patients, and the mean FCS value in the fusiform gyrus was significantly correlated with Hamilton Depression Rating Scale scores.These findings may provide novel insight into the pathophysiology of RLS.CONCLUSIONSThese findings may provide novel insight into the pathophysiology of RLS. |
| Author | Wang, Li Zhan, Shuqin Wang, Jiaojian Qi, Zhigang Wang, Rong Wang, Yuping Hou, Yue Liu, Chunyan |
| Author_xml | – sequence: 1 givenname: Chunyan surname: Liu fullname: Liu, Chunyan organization: Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China – sequence: 2 givenname: Jiaojian surname: Wang fullname: Wang, Jiaojian organization: The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China – sequence: 3 givenname: Yue surname: Hou fullname: Hou, Yue organization: Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China – sequence: 4 givenname: Zhigang surname: Qi fullname: Qi, Zhigang organization: Department of Radiology, Xuan Wu Hospital, Capital Medical University, Beijing, China – sequence: 5 givenname: Li surname: Wang fullname: Wang, Li organization: Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China – sequence: 6 givenname: Shuqin surname: Zhan fullname: Zhan, Shuqin organization: Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China – sequence: 7 givenname: Rong surname: Wang fullname: Wang, Rong email: rong_wang72@aliyun.com organization: Central Laboratory, Xuan Wu Hospital, Capital Medical University, Beijing Institute for Brain Disorders, Center of Alzheimer's Disease, Beijing, China – sequence: 8 givenname: Yuping orcidid: 0000-0002-6482-9710 surname: Wang fullname: Wang, Yuping email: wangyuping01@sina.cn organization: Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29680421$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkU2PFCEQholZ437oLzAxHL10Cw3dTcd4MBu_kjVe9Eyq6WKGkYEWujeZf7-Ms3rYy5yA4nkq8NY1uQgxICGvOas54927XZ094lw3jPc1b-pSe0auuOpV1basuyh7oYZqkG1_Sa5z3rECciVfkMtm6BSTDb8im-8wzy5s6LJFarYQNjjR7TpmCmGiJqaEeY5hOiJ2DWZxMYAvFyFgOdy75UBdoG5ycYZl6wwtwuIxZ-pxk2k-hCnFPb4kzy34jK8e1xvy6_Onn7dfq7sfX77dfryrjOR8qbBplZIAEqWxtgeYegvdCGg5a4waYeRSMLCWc9Yr1ovBCmRtKSqlBAhxQ96e-s4p_lnLU_TeZYPeQ8C4Zt2w8nchpewK-uYRXcc9TnpObg_poP-FUwBxAkyKOSe0_xHO9HEEeqf_jkAfR6B5o0utWMMTy7gFjrktCZw_4344uVgiuneYdDYOg8HJpRK3nqI7479_4hvvgjPgf-PhrP0AATq5FA |
| CitedBy_id | crossref_primary_10_1007_s11682_018_0020_0 crossref_primary_10_1038_s41394_023_00576_4 crossref_primary_10_1111_jsr_13298 crossref_primary_10_3389_fnins_2020_00873 crossref_primary_10_1007_s11682_021_00537_1 crossref_primary_10_1111_jsr_14303 crossref_primary_10_1016_j_sleep_2024_11_020 crossref_primary_10_1016_j_smrv_2024_101949 crossref_primary_10_1038_s41398_022_01781_9 crossref_primary_10_1002_jmri_28682 crossref_primary_10_3389_fnagi_2022_1009632 crossref_primary_10_3389_fnins_2018_00692 crossref_primary_10_1177_1756286420941670 crossref_primary_10_3390_brainsci12010118 crossref_primary_10_1007_s40120_022_00397_x crossref_primary_10_3389_fnins_2021_746894 crossref_primary_10_3988_jcn_2022_18_3_290 crossref_primary_10_1007_s11682_021_00608_3 crossref_primary_10_1016_j_sleep_2020_07_026 crossref_primary_10_1093_cercor_bhab371 crossref_primary_10_1007_s00234_020_02451_7 crossref_primary_10_1016_j_sleep_2023_08_014 crossref_primary_10_1111_ene_14577 crossref_primary_10_1093_psyrad_kkac015 crossref_primary_10_1016_j_sleep_2020_05_040 |
| Cites_doi | 10.3174/ajnr.A2829 10.1097/00001756-200303240-00019 10.1002/mds.23353 10.1093/scan/nsx100 10.1007/BF00237906 10.1016/j.jad.2017.08.084 10.1002/ana.410410108 10.1073/pnas.98.2.676 10.1073/pnas.0604187103 10.1016/j.sleep.2016.05.007 10.1002/hbm.22241 10.1002/jnr.23705 10.1016/j.jad.2017.09.001 10.1002/hbm.23488 10.1016/j.sleep.2011.01.021 10.1016/j.neuron.2011.09.006 10.1152/jn.00338.2011 10.3389/fnana.2016.00120 10.1038/nrn2575 10.1002/hbm.22745 10.1371/journal.pbio.0060159 10.1212/WNL.0000000000001455 10.1093/cercor/bhr269 10.1002/ana.410410513 10.1007/s11682-015-9460-y 10.1016/j.sleep.2013.05.017 10.1093/gerona/glp161 10.1002/mds.25576 10.1016/j.pain.2006.02.023 10.1016/j.neuroimage.2012.07.045 10.1126/science.288.5472.1769 10.1093/brain/awl163 10.1002/hbm.23311 10.1002/hbm.22626 10.1016/j.neuron.2014.05.014 10.1093/brain/awg033 10.1016/S1474-4422(05)70139-3 10.1093/brain/awh441 10.1093/sleep/32.5.589 10.1016/j.sleep.2013.09.030 10.1016/j.neuroimage.2009.11.001 10.3389/fnins.2017.00259 10.1016/j.sleep.2014.12.029 10.1016/j.sleep.2016.07.018 10.1016/j.sleep.2007.03.021 10.1016/j.brs.2008.09.009 10.1016/j.neuroimage.2004.10.021 10.3389/fnana.2016.00041 10.1016/S1389-9457(03)00010-8 10.1038/nrn3901 10.1523/JNEUROSCI.5062-08.2009 10.1093/brain/aws266 10.1177/1073858406293182 10.1016/j.clinph.2004.01.031 10.1016/j.tics.2013.09.012 10.1038/nn1544 10.1053/smrv.1999.0075 10.1007/BF01244940 |
| ContentType | Journal Article |
| Copyright | 2018 Elsevier B.V. Copyright © 2018 Elsevier B.V. All rights reserved. |
| Copyright_xml | – notice: 2018 Elsevier B.V. – notice: Copyright © 2018 Elsevier B.V. All rights reserved. |
| DBID | AAYXX CITATION NPM 7X8 |
| DOI | 10.1016/j.sleep.2017.12.016 |
| DatabaseName | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | PubMed MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| EISSN | 1878-5506 |
| EndPage | 139 |
| ExternalDocumentID | 29680421 10_1016_j_sleep_2017_12_016 S1389945718300327 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- --K --M .1- .FO .~1 0R~ 123 1B1 1P~ 1~. 1~5 4.4 457 4G. 53G 5VS 6PF 7-5 71M 8P~ AABNK AAEDT AAEDW AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATTM AAWTL AAXKI AAXLA AAXUO AAYWO ABBQC ABCQJ ABFNM ABFRF ABIVO ABJNI ABMAC ABMZM ABWVN ABXDB ACDAQ ACGFO ACGFS ACIEU ACIUM ACRLP ACRPL ACVFH ADBBV ADCNI ADEZE ADMUD ADNMO AEBSH AEFWE AEIPS AEKER AENEX AEUPX AEVXI AFJKZ AFPUW AFRHN AFTJW AFXIZ AGCQF AGHFR AGQPQ AGUBO AGWIK AGYEJ AIEXJ AIGII AIIUN AIKHN AITUG AJRQY AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ANZVX APXCP ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CS3 DU5 EBS EFJIC EFKBS EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-Q GBLVA HVGLF HZ~ IHE J1W KOM M41 MO0 MOBAO N9A O-L O9- OAUVE OJ- OV. OZT P-8 P-9 P2P PC. Q38 R2- ROL RPZ SCC SDF SDG SEL SES SEW SJN SPCBC SSH SSN SSZ T5K UHS UNMZH UV1 Z5R ~G- ~S- AACTN AADPK AAIAV ABLVK ABYKQ AFCTW AFKWA AJBFU AJOXV AMFUW EFLBG LCYCR RIG AAYXX AGRNS CITATION NPM 7X8 |
| ID | FETCH-LOGICAL-c411t-e25884aa4e4cff7aad7fa6baef102c8bab1430aff110780739f3e051438883a33 |
| IEDL.DBID | AIKHN |
| ISSN | 1389-9457 1878-5506 |
| IngestDate | Thu Sep 04 17:59:58 EDT 2025 Wed Feb 19 02:37:15 EST 2025 Tue Jul 01 02:03:07 EDT 2025 Thu Apr 24 23:05:07 EDT 2025 Fri Feb 23 02:16:36 EST 2024 Tue Aug 26 20:35:39 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | Functional connectivity RLS Resting-state functional MRI Pathophysiology Hubs Network |
| Language | English |
| License | Copyright © 2018 Elsevier B.V. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c411t-e25884aa4e4cff7aad7fa6baef102c8bab1430aff110780739f3e051438883a33 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0002-6482-9710 |
| PMID | 29680421 |
| PQID | 2029634446 |
| PQPubID | 23479 |
| PageCount | 8 |
| ParticipantIDs | proquest_miscellaneous_2029634446 pubmed_primary_29680421 crossref_primary_10_1016_j_sleep_2017_12_016 crossref_citationtrail_10_1016_j_sleep_2017_12_016 elsevier_sciencedirect_doi_10_1016_j_sleep_2017_12_016 elsevier_clinicalkey_doi_10_1016_j_sleep_2017_12_016 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | May 2018 2018-05-00 20180501 |
| PublicationDateYYYYMMDD | 2018-05-01 |
| PublicationDate_xml | – month: 05 year: 2018 text: May 2018 |
| PublicationDecade | 2010 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands |
| PublicationTitle | Sleep medicine |
| PublicationTitleAlternate | Sleep Med |
| PublicationYear | 2018 |
| Publisher | Elsevier B.V |
| Publisher_xml | – name: Elsevier B.V |
| References | Bucher, Seelos, Dodel (bib41) 1997; 41 Wang, Fan, Wang (bib12) 2015; 36 Wang, Zhang, Rong (bib47) 2016 Rizzo, Li, Galantucci (bib40) 2017; 31 von Spiczak, Whone, Hammers (bib50) 2005; 128 Rizzo, Manners, Testa (bib28) 2013; 28 Bassett, Bullmore (bib19) 2006; 12 Wu, Sun, Xu (bib23) 2016; 10 Raichle, MacLeod, Snyder (bib45) 2001; 98 Mears, Pollard (bib16) 2016; 94 Fenton, Palmieri, Boggio (bib37) 2009; 2 Reidler, Mendonca, Santana (bib34) 2012; 13 Buhmann, Glauche, Sturenburg (bib33) 2003; 126 Carra-Dalliere, Menjot de Champfleur, Ayrignac (bib29) 2015; 84 Wu, Zhang, Liu (bib48) 2016; 10 Trenkwalder, Paulus (bib61) 2004; 115 Wang, Wei, Yuan (bib25) 2017; 225 Cole, Pathak, Schneider (bib21) 2010; 49 Mendonca, Santana, Baptista (bib36) 2011; 12 Etgen, Draganski, Ilg (bib60) 2005; 24 Fornito, Zalesky, Breakspear (bib27) 2015; 16 Winkelman, Gagnon, Clair (bib44) 2013; 14 Bullmore, Sporns (bib18) 2009; 10 Walters, Rye (bib55) 2009; 32 Buckner, Sepulcre, Talukdar (bib8) 2009; 29 Yeo, Krienen, Sepulcre (bib10) 2011; 106 Wang, Wei, Bai (bib24) 2017 Bucher, Seelos, Oertel (bib3) 1997; 41 Zhu, Lin, Lin (bib62) 2018; 225 Fulda, Beitinger, Reppermund (bib54) 2010; 25 Power, Cohen, Nelson (bib9) 2011; 72 Cervenka, Palhagen, Comley (bib32) 2006; 129 Hoshi, Tremblay, Feger (bib42) 2005; 8 Staedt, Stoppe, Kogler (bib43) 1993; 93 Wang, Fan, Zhang (bib11) 2012; 63 Wang, Tian, Wang (bib15) 2016; 10 van den Heuvel, Sporns (bib20) 2013; 17 Cole, Bassett, Power (bib14) 2014; 83 Fregni, Boggio, Lima (bib35) 2006; 122 Wik, Fischer, Bragee (bib38) 2003; 14 Hagmann, Cammoun, Gigandet (bib17) 2008; 6 Picchietti, Winkelman (bib57) 2005; 28 Margariti, Astrakas, Tsouli (bib4) 2012; 33 Fries, Zieglgansberger (bib39) 1974; 21 Price (bib51) 2000; 288 Liu, Dai, Zhang (bib6) 2015; 16 Fukui (bib58) 2008; 28 Ku, Cho, Lee (bib31) 2014; 15 Allen, Picchietti, Hening (bib1) 2003; 4 Zuo, Ehmke, Mennes (bib26) 2012; 22 Rizzo, Tonon, Testa (bib30) 2012; 135 Lustberg, Reynolds (bib56) 2000; 4 Wang, Xie, Guo (bib46) 2017; 38 Wang, Yang, Fan (bib13) 2015; 36 Fox, Corbetta, Snyder (bib7) 2006; 103 Spiegelhalder, Feige, Paul (bib5) 2008; 9 Trenkwalder, Paulus, Walters (bib2) 2005; 4 Karroum, Golmard, Leu-Semenescu (bib52) 2012; 13 Celle, Roche, Kerleroux (bib53) 2010; 65 Wang, Dai, Peng (bib22) 2014; 35 Ku, Lee, Chang (bib49) 2016; 23 Pang, Zhan, Zhang (bib59) 2017; 11 Carra-Dalliere (10.1016/j.sleep.2017.12.016_bib29) 2015; 84 Rizzo (10.1016/j.sleep.2017.12.016_bib30) 2012; 135 Buckner (10.1016/j.sleep.2017.12.016_bib8) 2009; 29 Price (10.1016/j.sleep.2017.12.016_bib51) 2000; 288 Winkelman (10.1016/j.sleep.2017.12.016_bib44) 2013; 14 Wu (10.1016/j.sleep.2017.12.016_bib48) 2016; 10 Wang (10.1016/j.sleep.2017.12.016_bib46) 2017; 38 Mears (10.1016/j.sleep.2017.12.016_bib16) 2016; 94 Wang (10.1016/j.sleep.2017.12.016_bib13) 2015; 36 Etgen (10.1016/j.sleep.2017.12.016_bib60) 2005; 24 Trenkwalder (10.1016/j.sleep.2017.12.016_bib61) 2004; 115 Trenkwalder (10.1016/j.sleep.2017.12.016_bib2) 2005; 4 Fox (10.1016/j.sleep.2017.12.016_bib7) 2006; 103 Hoshi (10.1016/j.sleep.2017.12.016_bib42) 2005; 8 Cervenka (10.1016/j.sleep.2017.12.016_bib32) 2006; 129 Cole (10.1016/j.sleep.2017.12.016_bib14) 2014; 83 Raichle (10.1016/j.sleep.2017.12.016_bib45) 2001; 98 Zhu (10.1016/j.sleep.2017.12.016_bib62) 2018; 225 Walters (10.1016/j.sleep.2017.12.016_bib55) 2009; 32 Picchietti (10.1016/j.sleep.2017.12.016_bib57) 2005; 28 Wik (10.1016/j.sleep.2017.12.016_bib38) 2003; 14 Rizzo (10.1016/j.sleep.2017.12.016_bib28) 2013; 28 Staedt (10.1016/j.sleep.2017.12.016_bib43) 1993; 93 Wang (10.1016/j.sleep.2017.12.016_bib15) 2016; 10 Fulda (10.1016/j.sleep.2017.12.016_bib54) 2010; 25 Lustberg (10.1016/j.sleep.2017.12.016_bib56) 2000; 4 Celle (10.1016/j.sleep.2017.12.016_bib53) 2010; 65 Mendonca (10.1016/j.sleep.2017.12.016_bib36) 2011; 12 Wang (10.1016/j.sleep.2017.12.016_bib25) 2017; 225 Zuo (10.1016/j.sleep.2017.12.016_bib26) 2012; 22 Fries (10.1016/j.sleep.2017.12.016_bib39) 1974; 21 Spiegelhalder (10.1016/j.sleep.2017.12.016_bib5) 2008; 9 Bassett (10.1016/j.sleep.2017.12.016_bib19) 2006; 12 Bucher (10.1016/j.sleep.2017.12.016_bib3) 1997; 41 Wang (10.1016/j.sleep.2017.12.016_bib11) 2012; 63 Karroum (10.1016/j.sleep.2017.12.016_bib52) 2012; 13 Power (10.1016/j.sleep.2017.12.016_bib9) 2011; 72 Pang (10.1016/j.sleep.2017.12.016_bib59) 2017; 11 Wu (10.1016/j.sleep.2017.12.016_bib23) 2016; 10 Rizzo (10.1016/j.sleep.2017.12.016_bib40) 2017; 31 Cole (10.1016/j.sleep.2017.12.016_bib21) 2010; 49 Fenton (10.1016/j.sleep.2017.12.016_bib37) 2009; 2 Yeo (10.1016/j.sleep.2017.12.016_bib10) 2011; 106 Fregni (10.1016/j.sleep.2017.12.016_bib35) 2006; 122 Allen (10.1016/j.sleep.2017.12.016_bib1) 2003; 4 Reidler (10.1016/j.sleep.2017.12.016_bib34) 2012; 13 Wang (10.1016/j.sleep.2017.12.016_bib47) 2016 Liu (10.1016/j.sleep.2017.12.016_bib6) 2015; 16 Ku (10.1016/j.sleep.2017.12.016_bib49) 2016; 23 van den Heuvel (10.1016/j.sleep.2017.12.016_bib20) 2013; 17 Bucher (10.1016/j.sleep.2017.12.016_bib41) 1997; 41 Margariti (10.1016/j.sleep.2017.12.016_bib4) 2012; 33 Buhmann (10.1016/j.sleep.2017.12.016_bib33) 2003; 126 von Spiczak (10.1016/j.sleep.2017.12.016_bib50) 2005; 128 Fukui (10.1016/j.sleep.2017.12.016_bib58) 2008; 28 Bullmore (10.1016/j.sleep.2017.12.016_bib18) 2009; 10 Ku (10.1016/j.sleep.2017.12.016_bib31) 2014; 15 Hagmann (10.1016/j.sleep.2017.12.016_bib17) 2008; 6 Wang (10.1016/j.sleep.2017.12.016_bib22) 2014; 35 Wang (10.1016/j.sleep.2017.12.016_bib12) 2015; 36 Wang (10.1016/j.sleep.2017.12.016_bib24) 2017 Fornito (10.1016/j.sleep.2017.12.016_bib27) 2015; 16 |
| References_xml | – volume: 129 start-page: 2017 year: 2006 end-page: 2028 ident: bib32 article-title: Support for dopaminergic hypoactivity in restless legs syndrome: a PET study on D2-receptor binding publication-title: Brain – volume: 2 start-page: 103 year: 2009 end-page: 107 ident: bib37 article-title: A preliminary study of transcranial direct current stimulation for the treatment of refractory chronic pelvic pain publication-title: Brain Stimul – volume: 94 start-page: 590 year: 2016 end-page: 605 ident: bib16 article-title: Network science and the human brain: using graph theory to understand the brain and one of its hubs, the amygdala, in health and disease publication-title: J Neurosci Res – volume: 63 start-page: 641 year: 2012 end-page: 652 ident: bib11 article-title: Tractography-based parcellation of the human left inferior parietal lobule publication-title: Neuroimage – volume: 122 start-page: 197 year: 2006 end-page: 209 ident: bib35 article-title: A sham-controlled, phase II trial of transcranial direct current stimulation for the treatment of central pain in traumatic spinal cord injury publication-title: Pain – volume: 225 start-page: 676 year: 2018 end-page: 683 ident: bib62 article-title: Selective functional dysconnectivity of the dorsal-anterior subregion of the precuneus in drug-naive major depressive disorder publication-title: J Affect Disord – volume: 13 start-page: 402 year: 2012 end-page: 408 ident: bib52 article-title: Sensations in restless legs syndrome publication-title: Sleep Med – volume: 28 start-page: 1886 year: 2013 end-page: 1890 ident: bib28 article-title: Low brain iron content in idiopathic restless legs syndrome patients detected by phase imaging publication-title: Mov Disord – volume: 16 start-page: 159 year: 2015 end-page: 172 ident: bib27 article-title: The connectomics of brain disorders publication-title: Nat Rev Neurosci – volume: 25 start-page: 2641 year: 2010 end-page: 2648 ident: bib54 article-title: Short-term attention and verbal fluency is decreased in restless legs syndrome patients publication-title: Mov Disord – volume: 135 start-page: 3712 year: 2012 end-page: 3720 ident: bib30 article-title: Abnormal medial thalamic metabolism in patients with idiopathic restless legs syndrome publication-title: Brain – volume: 36 start-page: 1908 year: 2015 end-page: 1924 ident: bib12 article-title: Determination of the posterior boundary of Wernicke's area based on multimodal connectivity profiles publication-title: Hum Brain Mapp – volume: 84 start-page: 1501 year: 2015 end-page: 1502 ident: bib29 article-title: Quantitative susceptibility mapping suggests a paramagnetic effect in PML publication-title: Neurology – volume: 9 start-page: 177 year: 2008 end-page: 183 ident: bib5 article-title: Cerebral correlates of muscle tone fluctuations in restless legs syndrome: a pilot study with combined functional magnetic resonance imaging and anterior tibial muscle electromyography publication-title: Sleep Med – volume: 288 start-page: 1769 year: 2000 end-page: 1772 ident: bib51 article-title: Psychological and neural mechanisms of the affective dimension of pain publication-title: Science – volume: 103 start-page: 10046 year: 2006 end-page: 10051 ident: bib7 article-title: Spontaneous neuronal activity distinguishes human dorsal and ventral attention systems publication-title: Proc Natl Acad Sci U S A – volume: 22 start-page: 1862 year: 2012 end-page: 1875 ident: bib26 article-title: Network centrality in the human functional connectome publication-title: Cereb Cortex – volume: 12 start-page: 512 year: 2006 end-page: 523 ident: bib19 article-title: Small-world brain networks publication-title: Neuroscientist – volume: 36 start-page: 238 year: 2015 end-page: 257 ident: bib13 article-title: Convergent functional architecture of the superior parietal lobule unraveled with multimodal neuroimaging approaches publication-title: Hum Brain Mapp – volume: 93 start-page: 71 year: 1993 end-page: 74 ident: bib43 article-title: Dopamine D2 receptor alteration in patients with periodic movements in sleep (nocturnal myoclonus) publication-title: J Neural Transm Gen Sect – volume: 10 year: 2016 ident: bib48 article-title: Distinct changes in functional connectivity in posteromedial cortex subregions during the progress of Alzheimer's disease publication-title: Front Neuroanat – volume: 13 start-page: 450 year: 2012 end-page: 458 ident: bib34 article-title: Effects of motor cortex modulation and descending inhibitory systems on pain thresholds in healthy subjects publication-title: J Pain – volume: 10 start-page: 1029 year: 2016 end-page: 1037 ident: bib15 article-title: A lateralized top-down network for visuospatial attention and neglect publication-title: Brain Imag Behav – volume: 106 start-page: 1125 year: 2011 end-page: 1165 ident: bib10 article-title: The organization of the human cerebral cortex estimated by intrinsic functional connectivity publication-title: J Neurophysiol – volume: 126 start-page: 451 year: 2003 end-page: 461 ident: bib33 article-title: Pharmacologically modulated fMRI─cortical responsiveness to levodopa in drug-naive hemiparkinsonian patients publication-title: Brain – volume: 23 start-page: 6 year: 2016 end-page: 11 ident: bib49 article-title: Default mode network disturbances in restless legs syndrome/Willis-Ekbom disease publication-title: Sleep Med – volume: 4 start-page: 465 year: 2005 end-page: 475 ident: bib2 article-title: The restless legs syndrome publication-title: Lancet Neurol – volume: 10 start-page: 186 year: 2009 end-page: 198 ident: bib18 article-title: Complex brain networks: graph theoretical analysis of structural and functional systems publication-title: Nat Rev Neurosci – volume: 24 start-page: 1242 year: 2005 end-page: 1247 ident: bib60 article-title: Bilateral thalamic gray matter changes in patients with restless legs syndrome publication-title: Neuroimage – volume: 8 start-page: 1491 year: 2005 end-page: 1493 ident: bib42 article-title: The cerebellum communicates with the basal ganglia publication-title: Nat Neurosci – volume: 72 start-page: 665 year: 2011 end-page: 678 ident: bib9 article-title: Functional network organization of the human brain publication-title: Neuron – volume: 32 start-page: 589 year: 2009 end-page: 597 ident: bib55 article-title: Review of the relationship of restless legs syndrome and periodic limb movements in sleep to hypertension, heart disease, and stroke publication-title: Sleep – volume: 41 start-page: 639 year: 1997 end-page: 645 ident: bib3 article-title: Cerebral generators involved in the pathogenesis of the restless legs syndrome publication-title: Ann Neurol – volume: 14 start-page: 934 year: 2013 end-page: 942 ident: bib44 article-title: Sensory symptoms in restless legs syndrome: the enigma of pain publication-title: Sleep Med – volume: 28 start-page: 891 year: 2005 end-page: 898 ident: bib57 article-title: Restless legs syndrome, periodic limb movements in sleep, and depression publication-title: Sleep – volume: 14 start-page: 619 year: 2003 end-page: 621 ident: bib38 article-title: Retrosplenial cortical activation in the fibromyalgia syndrome publication-title: Neuroreport – volume: 31 start-page: 39 year: 2017 end-page: 48 ident: bib40 article-title: Brain imaging and networks in restless legs syndrome publication-title: Sleep Med – volume: 49 start-page: 3132 year: 2010 end-page: 3148 ident: bib21 article-title: Identifying the brain's most globally connected regions publication-title: Neuroimage – year: 2017 ident: bib24 article-title: Electroconvulsive therapy selectively enhanced feedforward connectivity from fusiform face area to amygdala in major depressive disorder publication-title: Soc Cogn Affect Neurosci – volume: 15 start-page: 289 year: 2014 end-page: 294 ident: bib31 article-title: Functional connectivity alternation of the thalamus in restless legs syndrome patients during the asymptomatic period: a resting-state connectivity study using functional magnetic resonance imaging publication-title: Sleep Med – volume: 38 start-page: 1659 year: 2017 end-page: 1675 ident: bib46 article-title: Correspondent functional topography of the human left inferior parietal lobule at rest and under task revealed using resting-state fMRI and coactivation based parcellation publication-title: Hum Brain Mapp – volume: 6 start-page: e159 year: 2008 ident: bib17 article-title: Mapping the structural core of human cerebral cortex publication-title: PLoS Biol – volume: 28 start-page: 23 year: 2008 end-page: 28 ident: bib58 article-title: A magnetic resonance spectroscopy investigation of the anterior cingulate cortex and prefrontal cortex in chronic pain patients publication-title: Nihon Shinkei Seishin Yakurigaku Zasshi – volume: 65 start-page: 167 year: 2010 end-page: 173 ident: bib53 article-title: Prevalence and clinical correlates of restless legs syndrome in an elderly French population: the SYNAPSE study publication-title: J Gerontol A Biol Sci Med Sci – volume: 10 start-page: 120 year: 2016 ident: bib23 article-title: Changed hub and corresponding functional connectivity of subgenual anterior cingulate cortex in major depressive disorder publication-title: Front Neuroanat – volume: 225 start-page: 658 year: 2017 end-page: 664 ident: bib25 article-title: Local functional connectivity density is closely associated with the response of electroconvulsive therapy in major depressive disorder publication-title: J Affect Disord – volume: 12 start-page: 610 year: 2011 end-page: 617 ident: bib36 article-title: Transcranial DC stimulation in fibromyalgia: optimized cortical target supported by high-resolution computational models publication-title: J Pain – volume: 115 start-page: 1975 year: 2004 end-page: 1988 ident: bib61 article-title: Why do restless legs occur at rest? Pathophysiology of neuronal structures in RLS. Neurophysiology of RLS (part 2) publication-title: Clin Neurophysiol – volume: 83 start-page: 238 year: 2014 end-page: 251 ident: bib14 article-title: Intrinsic and task-evoked network architectures of the human brain publication-title: Neuron – volume: 41 start-page: 32 year: 1997 end-page: 40 ident: bib41 article-title: Activation mapping in essential tremor with functional magnetic resonance imaging publication-title: Ann Neurol – volume: 11 start-page: 259 year: 2017 ident: bib59 article-title: Aberrant functional connectivity architecture in participants with chronic insomnia disorder accompanying cognitive dysfunction: a whole-brain, data-driven analysis publication-title: Front Neurosci – volume: 17 start-page: 683 year: 2013 end-page: 696 ident: bib20 article-title: Network hubs in the human brain publication-title: Trends Cogn Sci – volume: 33 start-page: 667 year: 2012 end-page: 672 ident: bib4 article-title: Investigation of unmedicated early onset restless legs syndrome by voxel-based morphometry, T2 relaxometry, and functional MR imaging during the night-time hours publication-title: AJNR Am J Neuroradiol – volume: 4 start-page: 253 year: 2000 end-page: 262 ident: bib56 article-title: Depression and insomnia: questions of cause and effect publication-title: Sleep Med Rev – volume: 98 start-page: 676 year: 2001 end-page: 682 ident: bib45 article-title: A default mode of brain function publication-title: Proc Natl Acad Sci U S A – volume: 35 start-page: 1154 year: 2014 end-page: 1166 ident: bib22 article-title: Overlapping and segregated resting-state functional connectivity in patients with major depressive disorder with and without childhood neglect publication-title: Hum Brain Mapp – volume: 21 start-page: 441 year: 1974 end-page: 445 ident: bib39 article-title: A method to discriminate axonal from cellbody activity and to analyse “silent cells” publication-title: Exp Brain Res – volume: 4 start-page: 101 year: 2003 end-page: 109 ident: bib1 article-title: Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the national institutes of health publication-title: Sleep Med – year: 2016 ident: bib47 article-title: Functional topography of the right inferior parietal lobule structured by anatomical connectivity profiles publication-title: Hum Brain Mapp – volume: 29 start-page: 1860 year: 2009 end-page: 1873 ident: bib8 article-title: Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer's disease publication-title: J Neurosci – volume: 128 start-page: 906 year: 2005 end-page: 917 ident: bib50 article-title: The role of opioids in restless legs syndrome: an [11C]diprenorphine PET study publication-title: Brain – volume: 16 start-page: 785 year: 2015 end-page: 791 ident: bib6 article-title: Mapping intrinsic functional brain changes and repetitive transcranial magnetic stimulation neuromodulation in idiopathic restless legs syndrome: a resting-state functional magnetic resonance imaging study publication-title: Sleep Med – volume: 33 start-page: 667 year: 2012 ident: 10.1016/j.sleep.2017.12.016_bib4 article-title: Investigation of unmedicated early onset restless legs syndrome by voxel-based morphometry, T2 relaxometry, and functional MR imaging during the night-time hours publication-title: AJNR Am J Neuroradiol doi: 10.3174/ajnr.A2829 – volume: 14 start-page: 619 year: 2003 ident: 10.1016/j.sleep.2017.12.016_bib38 article-title: Retrosplenial cortical activation in the fibromyalgia syndrome publication-title: Neuroreport doi: 10.1097/00001756-200303240-00019 – volume: 25 start-page: 2641 year: 2010 ident: 10.1016/j.sleep.2017.12.016_bib54 article-title: Short-term attention and verbal fluency is decreased in restless legs syndrome patients publication-title: Mov Disord doi: 10.1002/mds.23353 – year: 2017 ident: 10.1016/j.sleep.2017.12.016_bib24 article-title: Electroconvulsive therapy selectively enhanced feedforward connectivity from fusiform face area to amygdala in major depressive disorder publication-title: Soc Cogn Affect Neurosci doi: 10.1093/scan/nsx100 – volume: 21 start-page: 441 year: 1974 ident: 10.1016/j.sleep.2017.12.016_bib39 article-title: A method to discriminate axonal from cellbody activity and to analyse “silent cells” publication-title: Exp Brain Res doi: 10.1007/BF00237906 – volume: 225 start-page: 676 year: 2018 ident: 10.1016/j.sleep.2017.12.016_bib62 article-title: Selective functional dysconnectivity of the dorsal-anterior subregion of the precuneus in drug-naive major depressive disorder publication-title: J Affect Disord doi: 10.1016/j.jad.2017.08.084 – volume: 41 start-page: 32 year: 1997 ident: 10.1016/j.sleep.2017.12.016_bib41 article-title: Activation mapping in essential tremor with functional magnetic resonance imaging publication-title: Ann Neurol doi: 10.1002/ana.410410108 – volume: 98 start-page: 676 year: 2001 ident: 10.1016/j.sleep.2017.12.016_bib45 article-title: A default mode of brain function publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.98.2.676 – volume: 103 start-page: 10046 year: 2006 ident: 10.1016/j.sleep.2017.12.016_bib7 article-title: Spontaneous neuronal activity distinguishes human dorsal and ventral attention systems publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0604187103 – volume: 23 start-page: 6 year: 2016 ident: 10.1016/j.sleep.2017.12.016_bib49 article-title: Default mode network disturbances in restless legs syndrome/Willis-Ekbom disease publication-title: Sleep Med doi: 10.1016/j.sleep.2016.05.007 – volume: 35 start-page: 1154 year: 2014 ident: 10.1016/j.sleep.2017.12.016_bib22 article-title: Overlapping and segregated resting-state functional connectivity in patients with major depressive disorder with and without childhood neglect publication-title: Hum Brain Mapp doi: 10.1002/hbm.22241 – volume: 28 start-page: 891 year: 2005 ident: 10.1016/j.sleep.2017.12.016_bib57 article-title: Restless legs syndrome, periodic limb movements in sleep, and depression publication-title: Sleep – volume: 94 start-page: 590 year: 2016 ident: 10.1016/j.sleep.2017.12.016_bib16 article-title: Network science and the human brain: using graph theory to understand the brain and one of its hubs, the amygdala, in health and disease publication-title: J Neurosci Res doi: 10.1002/jnr.23705 – volume: 225 start-page: 658 year: 2017 ident: 10.1016/j.sleep.2017.12.016_bib25 article-title: Local functional connectivity density is closely associated with the response of electroconvulsive therapy in major depressive disorder publication-title: J Affect Disord doi: 10.1016/j.jad.2017.09.001 – volume: 38 start-page: 1659 year: 2017 ident: 10.1016/j.sleep.2017.12.016_bib46 article-title: Correspondent functional topography of the human left inferior parietal lobule at rest and under task revealed using resting-state fMRI and coactivation based parcellation publication-title: Hum Brain Mapp doi: 10.1002/hbm.23488 – volume: 13 start-page: 402 year: 2012 ident: 10.1016/j.sleep.2017.12.016_bib52 article-title: Sensations in restless legs syndrome publication-title: Sleep Med doi: 10.1016/j.sleep.2011.01.021 – volume: 72 start-page: 665 year: 2011 ident: 10.1016/j.sleep.2017.12.016_bib9 article-title: Functional network organization of the human brain publication-title: Neuron doi: 10.1016/j.neuron.2011.09.006 – volume: 106 start-page: 1125 year: 2011 ident: 10.1016/j.sleep.2017.12.016_bib10 article-title: The organization of the human cerebral cortex estimated by intrinsic functional connectivity publication-title: J Neurophysiol doi: 10.1152/jn.00338.2011 – volume: 10 start-page: 120 year: 2016 ident: 10.1016/j.sleep.2017.12.016_bib23 article-title: Changed hub and corresponding functional connectivity of subgenual anterior cingulate cortex in major depressive disorder publication-title: Front Neuroanat doi: 10.3389/fnana.2016.00120 – volume: 10 start-page: 186 year: 2009 ident: 10.1016/j.sleep.2017.12.016_bib18 article-title: Complex brain networks: graph theoretical analysis of structural and functional systems publication-title: Nat Rev Neurosci doi: 10.1038/nrn2575 – volume: 36 start-page: 1908 year: 2015 ident: 10.1016/j.sleep.2017.12.016_bib12 article-title: Determination of the posterior boundary of Wernicke's area based on multimodal connectivity profiles publication-title: Hum Brain Mapp doi: 10.1002/hbm.22745 – volume: 6 start-page: e159 year: 2008 ident: 10.1016/j.sleep.2017.12.016_bib17 article-title: Mapping the structural core of human cerebral cortex publication-title: PLoS Biol doi: 10.1371/journal.pbio.0060159 – volume: 84 start-page: 1501 year: 2015 ident: 10.1016/j.sleep.2017.12.016_bib29 article-title: Quantitative susceptibility mapping suggests a paramagnetic effect in PML publication-title: Neurology doi: 10.1212/WNL.0000000000001455 – volume: 22 start-page: 1862 year: 2012 ident: 10.1016/j.sleep.2017.12.016_bib26 article-title: Network centrality in the human functional connectome publication-title: Cereb Cortex doi: 10.1093/cercor/bhr269 – volume: 41 start-page: 639 year: 1997 ident: 10.1016/j.sleep.2017.12.016_bib3 article-title: Cerebral generators involved in the pathogenesis of the restless legs syndrome publication-title: Ann Neurol doi: 10.1002/ana.410410513 – volume: 10 start-page: 1029 year: 2016 ident: 10.1016/j.sleep.2017.12.016_bib15 article-title: A lateralized top-down network for visuospatial attention and neglect publication-title: Brain Imag Behav doi: 10.1007/s11682-015-9460-y – volume: 14 start-page: 934 year: 2013 ident: 10.1016/j.sleep.2017.12.016_bib44 article-title: Sensory symptoms in restless legs syndrome: the enigma of pain publication-title: Sleep Med doi: 10.1016/j.sleep.2013.05.017 – volume: 65 start-page: 167 year: 2010 ident: 10.1016/j.sleep.2017.12.016_bib53 article-title: Prevalence and clinical correlates of restless legs syndrome in an elderly French population: the SYNAPSE study publication-title: J Gerontol A Biol Sci Med Sci doi: 10.1093/gerona/glp161 – volume: 28 start-page: 1886 year: 2013 ident: 10.1016/j.sleep.2017.12.016_bib28 article-title: Low brain iron content in idiopathic restless legs syndrome patients detected by phase imaging publication-title: Mov Disord doi: 10.1002/mds.25576 – volume: 122 start-page: 197 year: 2006 ident: 10.1016/j.sleep.2017.12.016_bib35 article-title: A sham-controlled, phase II trial of transcranial direct current stimulation for the treatment of central pain in traumatic spinal cord injury publication-title: Pain doi: 10.1016/j.pain.2006.02.023 – volume: 63 start-page: 641 year: 2012 ident: 10.1016/j.sleep.2017.12.016_bib11 article-title: Tractography-based parcellation of the human left inferior parietal lobule publication-title: Neuroimage doi: 10.1016/j.neuroimage.2012.07.045 – volume: 288 start-page: 1769 year: 2000 ident: 10.1016/j.sleep.2017.12.016_bib51 article-title: Psychological and neural mechanisms of the affective dimension of pain publication-title: Science doi: 10.1126/science.288.5472.1769 – volume: 129 start-page: 2017 year: 2006 ident: 10.1016/j.sleep.2017.12.016_bib32 article-title: Support for dopaminergic hypoactivity in restless legs syndrome: a PET study on D2-receptor binding publication-title: Brain doi: 10.1093/brain/awl163 – year: 2016 ident: 10.1016/j.sleep.2017.12.016_bib47 article-title: Functional topography of the right inferior parietal lobule structured by anatomical connectivity profiles publication-title: Hum Brain Mapp doi: 10.1002/hbm.23311 – volume: 36 start-page: 238 year: 2015 ident: 10.1016/j.sleep.2017.12.016_bib13 article-title: Convergent functional architecture of the superior parietal lobule unraveled with multimodal neuroimaging approaches publication-title: Hum Brain Mapp doi: 10.1002/hbm.22626 – volume: 83 start-page: 238 year: 2014 ident: 10.1016/j.sleep.2017.12.016_bib14 article-title: Intrinsic and task-evoked network architectures of the human brain publication-title: Neuron doi: 10.1016/j.neuron.2014.05.014 – volume: 126 start-page: 451 year: 2003 ident: 10.1016/j.sleep.2017.12.016_bib33 article-title: Pharmacologically modulated fMRI─cortical responsiveness to levodopa in drug-naive hemiparkinsonian patients publication-title: Brain doi: 10.1093/brain/awg033 – volume: 4 start-page: 465 year: 2005 ident: 10.1016/j.sleep.2017.12.016_bib2 article-title: The restless legs syndrome publication-title: Lancet Neurol doi: 10.1016/S1474-4422(05)70139-3 – volume: 128 start-page: 906 year: 2005 ident: 10.1016/j.sleep.2017.12.016_bib50 article-title: The role of opioids in restless legs syndrome: an [11C]diprenorphine PET study publication-title: Brain doi: 10.1093/brain/awh441 – volume: 32 start-page: 589 year: 2009 ident: 10.1016/j.sleep.2017.12.016_bib55 article-title: Review of the relationship of restless legs syndrome and periodic limb movements in sleep to hypertension, heart disease, and stroke publication-title: Sleep doi: 10.1093/sleep/32.5.589 – volume: 13 start-page: 450 year: 2012 ident: 10.1016/j.sleep.2017.12.016_bib34 article-title: Effects of motor cortex modulation and descending inhibitory systems on pain thresholds in healthy subjects publication-title: J Pain – volume: 28 start-page: 23 year: 2008 ident: 10.1016/j.sleep.2017.12.016_bib58 article-title: A magnetic resonance spectroscopy investigation of the anterior cingulate cortex and prefrontal cortex in chronic pain patients publication-title: Nihon Shinkei Seishin Yakurigaku Zasshi – volume: 15 start-page: 289 year: 2014 ident: 10.1016/j.sleep.2017.12.016_bib31 article-title: Functional connectivity alternation of the thalamus in restless legs syndrome patients during the asymptomatic period: a resting-state connectivity study using functional magnetic resonance imaging publication-title: Sleep Med doi: 10.1016/j.sleep.2013.09.030 – volume: 49 start-page: 3132 year: 2010 ident: 10.1016/j.sleep.2017.12.016_bib21 article-title: Identifying the brain's most globally connected regions publication-title: Neuroimage doi: 10.1016/j.neuroimage.2009.11.001 – volume: 11 start-page: 259 year: 2017 ident: 10.1016/j.sleep.2017.12.016_bib59 article-title: Aberrant functional connectivity architecture in participants with chronic insomnia disorder accompanying cognitive dysfunction: a whole-brain, data-driven analysis publication-title: Front Neurosci doi: 10.3389/fnins.2017.00259 – volume: 16 start-page: 785 year: 2015 ident: 10.1016/j.sleep.2017.12.016_bib6 article-title: Mapping intrinsic functional brain changes and repetitive transcranial magnetic stimulation neuromodulation in idiopathic restless legs syndrome: a resting-state functional magnetic resonance imaging study publication-title: Sleep Med doi: 10.1016/j.sleep.2014.12.029 – volume: 31 start-page: 39 year: 2017 ident: 10.1016/j.sleep.2017.12.016_bib40 article-title: Brain imaging and networks in restless legs syndrome publication-title: Sleep Med doi: 10.1016/j.sleep.2016.07.018 – volume: 12 start-page: 610 year: 2011 ident: 10.1016/j.sleep.2017.12.016_bib36 article-title: Transcranial DC stimulation in fibromyalgia: optimized cortical target supported by high-resolution computational models publication-title: J Pain – volume: 9 start-page: 177 year: 2008 ident: 10.1016/j.sleep.2017.12.016_bib5 article-title: Cerebral correlates of muscle tone fluctuations in restless legs syndrome: a pilot study with combined functional magnetic resonance imaging and anterior tibial muscle electromyography publication-title: Sleep Med doi: 10.1016/j.sleep.2007.03.021 – volume: 2 start-page: 103 year: 2009 ident: 10.1016/j.sleep.2017.12.016_bib37 article-title: A preliminary study of transcranial direct current stimulation for the treatment of refractory chronic pelvic pain publication-title: Brain Stimul doi: 10.1016/j.brs.2008.09.009 – volume: 24 start-page: 1242 year: 2005 ident: 10.1016/j.sleep.2017.12.016_bib60 article-title: Bilateral thalamic gray matter changes in patients with restless legs syndrome publication-title: Neuroimage doi: 10.1016/j.neuroimage.2004.10.021 – volume: 10 year: 2016 ident: 10.1016/j.sleep.2017.12.016_bib48 article-title: Distinct changes in functional connectivity in posteromedial cortex subregions during the progress of Alzheimer's disease publication-title: Front Neuroanat doi: 10.3389/fnana.2016.00041 – volume: 4 start-page: 101 year: 2003 ident: 10.1016/j.sleep.2017.12.016_bib1 article-title: Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the national institutes of health publication-title: Sleep Med doi: 10.1016/S1389-9457(03)00010-8 – volume: 16 start-page: 159 year: 2015 ident: 10.1016/j.sleep.2017.12.016_bib27 article-title: The connectomics of brain disorders publication-title: Nat Rev Neurosci doi: 10.1038/nrn3901 – volume: 29 start-page: 1860 year: 2009 ident: 10.1016/j.sleep.2017.12.016_bib8 article-title: Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer's disease publication-title: J Neurosci doi: 10.1523/JNEUROSCI.5062-08.2009 – volume: 135 start-page: 3712 year: 2012 ident: 10.1016/j.sleep.2017.12.016_bib30 article-title: Abnormal medial thalamic metabolism in patients with idiopathic restless legs syndrome publication-title: Brain doi: 10.1093/brain/aws266 – volume: 12 start-page: 512 year: 2006 ident: 10.1016/j.sleep.2017.12.016_bib19 article-title: Small-world brain networks publication-title: Neuroscientist doi: 10.1177/1073858406293182 – volume: 115 start-page: 1975 year: 2004 ident: 10.1016/j.sleep.2017.12.016_bib61 article-title: Why do restless legs occur at rest? Pathophysiology of neuronal structures in RLS. Neurophysiology of RLS (part 2) publication-title: Clin Neurophysiol doi: 10.1016/j.clinph.2004.01.031 – volume: 17 start-page: 683 year: 2013 ident: 10.1016/j.sleep.2017.12.016_bib20 article-title: Network hubs in the human brain publication-title: Trends Cogn Sci doi: 10.1016/j.tics.2013.09.012 – volume: 8 start-page: 1491 year: 2005 ident: 10.1016/j.sleep.2017.12.016_bib42 article-title: The cerebellum communicates with the basal ganglia publication-title: Nat Neurosci doi: 10.1038/nn1544 – volume: 4 start-page: 253 year: 2000 ident: 10.1016/j.sleep.2017.12.016_bib56 article-title: Depression and insomnia: questions of cause and effect publication-title: Sleep Med Rev doi: 10.1053/smrv.1999.0075 – volume: 93 start-page: 71 year: 1993 ident: 10.1016/j.sleep.2017.12.016_bib43 article-title: Dopamine D2 receptor alteration in patients with periodic movements in sleep (nocturnal myoclonus) publication-title: J Neural Transm Gen Sect doi: 10.1007/BF01244940 |
| SSID | ssj0017184 |
| Score | 2.3535125 |
| Snippet | The hubs of the brain network play a key role in integrating and transferring information between different functional modules. However, whether the changed... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 132 |
| SubjectTerms | Functional connectivity Hubs Network Pathophysiology Resting-state functional MRI RLS |
| Title | Mapping the changed hubs and corresponding functional connectivity in idiopathic restless legs syndrome |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S1389945718300327 https://dx.doi.org/10.1016/j.sleep.2017.12.016 https://www.ncbi.nlm.nih.gov/pubmed/29680421 https://www.proquest.com/docview/2029634446 |
| Volume | 45 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3da9swED_a9GUvY2Vf2UfQYI_zEsuybD2W0JJ9lbGt0DdxkqXMJThhSV_7t_ck2YHC2sEeLeuwfTr_dKf7AniPuTMz05BZ4oTIhDMyo31cZajqsnTKCYkx2uJcLi7E58vy8gDmQy5MCKvssT9hekTrfmTac3O6advpz-BiU6IkcC1INHl1CEe8ULIcwdHJpy-L870zgWak3ra1ygLBUHwohnltV86FupV5FY8FQ9_zv29Q9ymgcSM6ewKPew2SnaSXPIYD1z2F5TcMhRaWjPQ5lpJ5G_abQIFh1zAbW3Bs1jGDhYWtLJ0A0g2CWZsaSLC2Y23TrmOPYstCz44VwSBbueWWDYUNnsHF2emv-SLreyhkVuT5LnM8ZKIiCies9xViU3mUBp0nzcLWBg0pTDP0PtiBdXDb-cKFmugFmcYFFsVzGHXrzr0EJrGeYYkGLa2rkpXyxnOUjVe8LCyfjYEPjNO2LzAe-lys9BBJdqUjt3Xgts65prExfNgTbVJ9jYeni2FF9JA6SmCnCf8fJpN7sjvS9W_Cd8Oya_rvgjMFO7e-3tIkTtglyJoew4skD_sPoDs1gWH-6n8f-xoe0VWdAivfwGj359q9JeVnZyZw-PEmn5CIz398_T7pRf0WB3UHMA |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT8MwDI7GOMAFgXiNZ5A4Ura26euIJtCAjQtM4hY5aTKKpm5i25XfjpO0k5BgSFzjWG0d97OT-EHIJfhKdESO2xLFmMeUiD2045kHWRpFKlMsBhtt8RT3huzhNXptkG6dC2PCKivsd5hu0boaaVfSbE-Lov1srtgyFiG4hqiaQbJG1lkUJiau7_pzGefhI911tk0zz0yvSw_ZIK_ZWClTtdJP7KGg6Xr-s3n6zf20Zuhum2xV_iO9ca-4Qxqq3CWjAZgyCyOK3hx1qbw5fUNIoFDmVNoGHNOJzV-hxpC58z8kIMhK1z6CFiUt8mJiOxRLajp2jBEE6ViNZrQua7BHhne3L92eV3VQ8CTz_bmnApOHCsAUk1onAHmiIRagNPoVMhUg0F3qgNZmF5iaSzsdKlMRPcSNcQhhuE-a5aRUh4TGkHYgAgESVzWLk0wLHUCc6yyIQhl0WiSoBcdlVV7cdLkY8zqO7J1baXMjbe4HHMda5GrJNHXVNVZPZ_WK8DpxFKGOI_qvZouXbN9062_Gi3rZOf515ioFSjVZzHBSgMjFcC_dIgdOH5YfgJQUodA_-u9jz8lG72XQ5_37p8djsomU1IVYnpDm_GOhTtENmoszq-ZfENIGZg |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Mapping+the+changed+hubs+and+corresponding+functional+connectivity+in+idiopathic+restless+legs+syndrome&rft.jtitle=Sleep+medicine&rft.au=Liu%2C+Chunyan&rft.au=Wang%2C+Jiaojian&rft.au=Hou%2C+Yue&rft.au=Qi%2C+Zhigang&rft.date=2018-05-01&rft.issn=1878-5506&rft.eissn=1878-5506&rft.volume=45&rft.spage=132&rft_id=info:doi/10.1016%2Fj.sleep.2017.12.016&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1389-9457&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1389-9457&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1389-9457&client=summon |