P2X7 Receptor Activity Limits Accumulation of T Cells within Tumors

• Published in: Cancer research (Chicago, Ill.) Vol. 80; no. 18; pp. 3906 - 3919
• Main Authors: Romagnani, Andrea, Rottoli, Elsa, Mazza, Emilia Maria Cristina, Rezzonico-Jost, Tanja, De Ponte Conti, Benedetta, Proietti, Michele, Perotti, Michela, Civanelli, Elisa, Perruzza, Lisa, Catapano, Alberico L., Baragetti, Andrea, Tenedini, Elena, Tagliafico, Enrico, Falzoni, Simonetta, Di Virgilio, Francesco, Norata, Giuseppe Danilo, Bicciato, Silvio, Grassi, Fabio
• Format: Journal Article
• Language: English
• Published: United States 15.09.2020
• Subjects: Adenosine Triphosphate - metabolism; Animals; CD4-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - immunology; Cell Cycle; Cell Line, Tumor; Cell Migration Inhibition; Cellular Senescence - immunology; Cyclin-Dependent Kinase Inhibitor p21 - metabolism; Flow Cytometry - methods; Gene Expression Profiling; Humans; Immune Checkpoint Inhibitors - therapeutic use; Immunotherapy, Adoptive - methods; Lymphocytes, Tumor-Infiltrating - immunology; Lymphocytes, Tumor-Infiltrating - metabolism; Melanoma, Experimental - immunology; Melanoma, Experimental - pathology; Melanoma, Experimental - therapy; Mice; Mice, Inbred C57BL; Mitochondria - metabolism; Neoplasm Transplantation; Purinergic P2X Receptor Antagonists; Reactive Oxygen Species - metabolism; Receptors, Purinergic P2X7 - deficiency; Receptors, Purinergic P2X7 - metabolism; T-Lymphocytes, Cytotoxic - immunology; Transcription, Genetic; Tumor Microenvironment - immunology; Up-Regulation

Extracellular ATP (eATP) is a signaling molecule that variably affects all cells of the immune system either directly or after hydrolysis to adenosine. Although eATP is virtually absent in the interstitium of normal tissues, it can be present in the hundreds of micromolar range in tumors, a concentr...