P2X7 Receptor Activity Limits Accumulation of T Cells within Tumors - Romagnani, Andrea; Rottoli, Elsa; Mazza, Emilia Maria Cristina; Rezzonico-Jost, Tanja; De Ponte Conti, Benedetta; Proietti, Michele; Perotti, Michela; Civanelli, Elisa; Perruzza, Lisa; Catapano, Alberico L.; Baragetti, Andrea; Tenedini, Elena; et al. (Cancer research (Chicago, Ill.), 2020)
Keywords: Adenosine Triphosphate - metabolism; Animals; CD4-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - immunology; Cell Cycle; Cell Line, Tumor; Cell Migration Inhibition; Cellular Senescence - immunology; Cyclin-Dependent Kinase Inhibitor p21 - metabolism; Flow Cytometry - methods; Gene Expression Profiling; Humans; Immune Checkpoint Inhibitors - therapeutic use; Immunotherapy, Adoptive - methods; Lymphocytes, Tumor-Infiltrating - immunology; Lymphocytes, Tumor-Infiltrating - metabolism; Melanoma, Experimental - immunology; Melanoma, Experimental - pathology; Melanoma, Experimental - therapy; Mice; Mice, Inbred C57BL; Mitochondria - metabolism; Neoplasm Transplantation; Purinergic P2X Receptor Antagonists; Reactive Oxygen Species - metabolism; Receptors, Purinergic P2X7 - deficiency; Receptors, Purinergic P2X7 - metabolism; T-Lymphocytes, Cytotoxic - immunology; Transcription, Genetic; Tumor Microenvironment - immunology; Up-Regulation