The Use of Infant Pulmonary Function Tests in the Diagnosis of Neuroendocrine Cell Hyperplasia of Infancy

• Published in: Chest Vol. 160; no. 4; pp. 1397 - 1405
• Main Authors: Breuer, Oded, Cohen-Cymberknoh, Malena, Picard, Elie, Bentur, Lea, Bar-Yoseph, Ronen, Shoseyov, David, Tsabari, Reuven, Kerem, Eitan, Hevroni, Avigdor
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2021
• Subjects: airway obstruction; Case-Control Studies; Female; Functional Residual Capacity; Humans; Hyperplasia - diagnosis; Hyperplasia - physiopathology; Hypoxia - physiopathology; Infant; Infant, Premature; interstitial lung disease; Lung Diseases - diagnosis; Lung Diseases - pathology; Lung Diseases - physiopathology; Male; Neuroendocrine Cells - pathology; pediatrics; Plethysmography; pulmonary function test; Residual Volume; Respiratory Function Tests - methods; Respiratory Sounds - physiopathology; Sensitivity and Specificity; Spirometry - methods; Tachypnea - physiopathology; Total Lung Capacity; trapped air; FRCpleth; RV; Crs; iPFT; trapped air; FEV0.5; ROC; TLC; airway obstruction; interstitial lung disease; V̇maxFRC; pediatrics; pulmonary function test; NEHI

Infant pulmonary function tests (iPFTs) in subjects with neuroendocrine cell hyperplasia of infancy (NEHI) have demonstrated substantial expiratory airflow obstruction and air trapping. Can indices from iPFTs be used in the diagnosis of NEHI? This is an observational case-control study evaluating iP...