Neuroprotective strategies to prevent and treat Parkinson’s disease based on its pathophysiological mechanism

Parkinson’s disease (PD) is the second most common progressive neurodegenerative disease after Alzheimer’s disease. PD exhibits clinical symptoms that include tremors, rigidity, and bradykinesia. Many drugs are available to treat PD, such as, l -dopa, COMT inhibitor, MAO-B inhibitor, and dopamine ag...

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Published inArchives of pharmacal research Vol. 40; no. 10; pp. 1117 - 1128
Main Authors Lee, Yujeong, Kim, Min-Sun, Lee, Jaewon
Format Journal Article
LanguageEnglish
Published Seoul Pharmaceutical Society of Korea 01.10.2017
대한약학회
Subjects
agonists
Alzheimer disease
Cytokines - metabolism
dopamine
Dopaminergic Neurons - drug effects
Dopaminergic Neurons - immunology
drugs
etiology
Humans
Inflammation
L-dopa
Medicine
Membrane Potential, Mitochondrial - drug effects
Microglia - drug effects
Microglia - immunology
mitochondria
Neuroprotective Agents - therapeutic use
oxidative stress
Oxidative Stress - drug effects
Parkinson disease
Parkinson Disease - drug therapy
Parkinson Disease - etiology
Parkinson Disease - immunology
Pharmacology/Toxicology
Pharmacy
Plant Preparations - therapeutic use
Review
약학
Pathophysiological pathway
Oxidative stress
Phytochemicals
Mitochondrial dysfunction
Neuroinflammation
Parkinson’s disease
Adaptive cellular stress response
Online AccessGet full text
ISSN0253-6269
1976-3786
1976-3786
DOI10.1007/s12272-017-0960-8

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Abstract Parkinson’s disease (PD) is the second most common progressive neurodegenerative disease after Alzheimer’s disease. PD exhibits clinical symptoms that include tremors, rigidity, and bradykinesia. Many drugs are available to treat PD, such as, l -dopa, COMT inhibitor, MAO-B inhibitor, and dopamine agonists, but these drugs simply compensate for dopamine loss in PD, and therefore, cannot completely suppress its symptoms or progression. Although the causes of PD are not clearly understood, common pathophysiological pathways, such as, oxidative stress, mitochondrial dysfunction, and neuroinflammation are considered to be etiological factors, and thus, many treatments and interventions have been developed to target these pathophysiological factors. This review describes the neuroprotective strategies devised based on current understanding of the pathophysiological mechanisms of PD.
AbstractList Parkinson’s disease (PD) is the second most common progressive neurodegenerative disease after Alzheimer’s disease. PD exhibits clinical symptoms that include tremors, rigidity, and bradykinesia. Many drugs are available to treat PD, such as, L-dopa, COMT inhibitor, MAO-B inhibitor, and dopamine agonists, but these drugs simply compensate for dopamine loss in PD, and therefore, cannot completely suppress its symptoms or progression. Although the causes of PD are not clearly understood, common pathophysiological pathways, such as, oxidative stress, mitochondrial dysfunction, and neuroinflammation are considered to be etiological factors, and thus, many treatments and interventions have been developed to target these pathophysiological factors. This review describes the neuroprotective strategies devised based on current understanding of the pathophysiological mechanisms of PD.
Parkinson’s disease (PD) is the second most common progressive neurodegenerative disease after Alzheimer’s disease. PD exhibits clinical symptoms that include tremors, rigidity, and bradykinesia. Many drugs are available to treat PD, such as, l -dopa, COMT inhibitor, MAO-B inhibitor, and dopamine agonists, but these drugs simply compensate for dopamine loss in PD, and therefore, cannot completely suppress its symptoms or progression. Although the causes of PD are not clearly understood, common pathophysiological pathways, such as, oxidative stress, mitochondrial dysfunction, and neuroinflammation are considered to be etiological factors, and thus, many treatments and interventions have been developed to target these pathophysiological factors. This review describes the neuroprotective strategies devised based on current understanding of the pathophysiological mechanisms of PD.
Parkinson's disease (PD) is the second most common progressive neurodegenerative disease after Alzheimer's disease. PD exhibits clinical symptoms that include tremors, rigidity, and bradykinesia. Many drugs are available to treat PD, such as, L-dopa, COMT inhibitor, MAO-B inhibitor, and dopamine agonists, but these drugs simply compensate for dopamine loss in PD, and therefore, cannot completely suppress its symptoms or progression. Although the causes of PD are not clearly understood, common pathophysiological pathways, such as, oxidative stress, mitochondrial dysfunction, and neuroinflammation are considered to be etiological factors, and thus, many treatments and interventions have been developed to target these pathophysiological factors. This review describes the neuroprotective strategies devised based on current understanding of the pathophysiological mechanisms of PD.Parkinson's disease (PD) is the second most common progressive neurodegenerative disease after Alzheimer's disease. PD exhibits clinical symptoms that include tremors, rigidity, and bradykinesia. Many drugs are available to treat PD, such as, L-dopa, COMT inhibitor, MAO-B inhibitor, and dopamine agonists, but these drugs simply compensate for dopamine loss in PD, and therefore, cannot completely suppress its symptoms or progression. Although the causes of PD are not clearly understood, common pathophysiological pathways, such as, oxidative stress, mitochondrial dysfunction, and neuroinflammation are considered to be etiological factors, and thus, many treatments and interventions have been developed to target these pathophysiological factors. This review describes the neuroprotective strategies devised based on current understanding of the pathophysiological mechanisms of PD.
Parkinson’s disease (PD) is the second mostcommon progressive neurodegenerative disease after Alzheimer’sdisease. PD exhibits clinical symptoms thatinclude tremors, rigidity, and bradykinesia. Many drugs areavailable to treat PD, such as, L-dopa, COMT inhibitor,MAO-B inhibitor, and dopamine agonists, but these drugssimply compensate for dopamine loss in PD, and therefore,cannot completely suppress its symptoms or progression. Although the causes of PD are not clearly understood,common pathophysiological pathways, such as, oxidativestress, mitochondrial dysfunction, and neuroinflammationare considered to be etiological factors, and thus, manytreatments and interventions have been developed to targetthese pathophysiological factors. This review describes theneuroprotective strategies devised based on currentunderstanding of the pathophysiological mechanisms ofPD. KCI Citation Count: 9
Author Lee, Yujeong
Kim, Min-Sun
Lee, Jaewon
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  email: neuron@pusan.ac.kr
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Cites_doi 10.1007/s10571-013-9921-z
10.1016/j.lfs.2006.09.010
10.1016/j.lfs.2005.04.048
10.1016/j.nut.2012.03.007
10.1155/2012/921941
10.1016/j.expneurol.2005.01.013
10.1039/c0fo00103a
10.1002/bies.20471
10.1073/pnas.1015950108
10.1097/00002826-199901000-00005
10.1177/1073858415574600
10.1016/j.tox.2008.06.010
10.1016/j.neurobiolaging.2010.05.021
10.1523/JNEUROSCI.3944-09.2010
10.1186/2045-8118-9-4
10.1016/j.taap.2007.02.015
10.1016/j.bbrc.2011.05.008
10.1007/s12031-013-0222-2
10.1056/NEJM2003ra020003
10.1523/JNEUROSCI.0730-12.2012
10.1161/HYPERTENSIONAHA.108.115873
10.1016/j.freeradbiomed.2008.03.005
10.1016/j.tins.2007.06.011
10.1016/j.cbi.2013.09.016
10.3892/ijmm.2013.1375
10.1126/science.1173635
10.1016/j.freeradbiomed.2007.08.015
10.1042/BST0351127
10.1021/bi8019178
10.1016/j.bbr.2011.02.005
10.1248/bpb.b12-00127
10.1038/ncomms4557
10.1007/s40263-015-0249-8
10.1111/j.1471-4159.2009.06394.x
10.1136/jnnp.62.1.10
10.1016/j.intimp.2007.12.012
10.1073/pnas.0602493103
10.1002/emmm.200900024
10.1046/j.1471-4159.2003.01657.x
10.1007/s00702-013-1062-5
10.1016/S1474-4422(06)70471-9
10.1073/pnas.0709336105
10.1016/j.expneurol.2007.07.004
10.3892/ijmm.2013.1280
10.1124/jpet.106.110866
10.1073/pnas.0609874104
10.5607/en.2015.24.4.325
10.1016/0306-4522(96)00047-4
10.1371/journal.pone.0037564
10.1038/nature11432
10.1016/j.taap.2017.01.019
10.1016/j.neulet.2008.10.046
10.1016/j.neuropharm.2011.04.021
10.1016/j.bbr.2014.11.030
10.1016/j.neurobiolaging.2012.07.008
10.1001/archneurol.2011.1060
10.1007/s11064-008-9729-2
10.2174/138161212798918995
10.1002/syn.20163
10.1002/ana.10277
10.1016/j.neulet.2008.05.005
10.1016/j.neulet.2005.04.022
10.1007/s11064-012-0909-8
10.1016/j.pbb.2013.05.012
10.12965/jer.1734906.453
10.1016/j.brainres.2015.09.029
10.1126/science.1096284
10.1016/j.neurobiolaging.2011.11.025
10.1080/14656566.2016.1219337
10.1016/j.brainres.2003.09.004
10.1179/135100002125000424
10.1097/WNR.0b013e32821c51fe
10.1016/S1353-8020(09)70831-4
10.1179/1743132812Y.0000000056
10.1016/j.nbd.2004.12.005
10.1002/jnr.23307
10.1016/j.brainres.2014.01.047
10.1016/j.parkreldis.2011.12.004
10.1016/j.neuroscience.2013.01.032
10.1016/j.neuroscience.2007.04.029
10.1016/j.neulet.2004.10.089
10.1007/s12640-011-9295-2
10.1002/jnr.23544
10.1016/j.bbrc.2008.10.104
10.1007/s13181-011-0162-6
10.1016/S0022-510X(99)00052-0
10.1016/j.jns.2012.05.030
10.1016/j.brainres.2017.03.018
10.1186/1756-0500-7-49
10.1136/bmj.310.6979.575
10.1016/S0031-6865(99)00038-2
10.1093/brain/awv407
10.1177/1535370215576313
10.1016/j.neuint.2012.12.016
10.1212/WNL.0b013e31824f7fc4
10.1016/j.bbadis.2008.12.006
10.1016/S0197-0186(97)00031-4
10.1016/S0301-0082(01)00003-X
10.1111/j.1749-6632.2003.tb07478.x
10.1016/j.tins.2007.03.009
10.1203/PDR.0b013e31821d02aa
10.1016/j.neuropharm.2013.11.026
10.1016/j.molcel.2009.02.013
10.1002/jnr.10309
10.1016/j.nurt.2007.12.001
10.1007/s11064-013-1079-z
10.1016/j.cbi.2016.03.023
10.1007/s10863-009-9250-6
10.3390/ijms18030551
10.3233/JAD-2010-100498
10.1016/0022-510X(95)00336-Z
10.1016/j.brainres.2010.02.031
10.1002/mds.26034
10.1002/ana.10489
10.1038/aps.2010.77
10.1042/bst0290684
10.2174/1570159X13666150703154541
10.1074/jbc.272.20.12893
10.2165/00003495-199855001-00004
10.1007/s10048-008-0137-1
10.1038/nature05292
10.1016/j.nut.2014.03.024
10.1002/ana.20882
10.1016/j.expneurol.2013.05.014
10.1038/nature01960
10.1111/j.1471-4159.2009.06403.x
10.1016/j.brainres.2017.02.021
10.1101/cshperspect.a008870
10.1007/s12035-014-8689-6
10.1016/S0306-4522(03)00096-4
10.1038/35086067
10.5114/fn.2015.54426
10.1016/S1474-4422(07)70327-7
10.1007/s00702-004-0213-0
10.1007/s40265-014-0343-0
10.1080/07315724.1997.10718679
10.1016/j.mam.2011.07.001
10.1016/j.pnpbp.2008.03.024
10.1002/(SICI)1097-4547(19990715)57:2<195::AID-JNR5>3.0.CO;2-P
10.1523/JNEUROSCI.18-04-01363.1998
10.3233/JPD-130186
10.1523/JNEUROSCI.19-21-09654.1999
10.1159/000118538
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Parkinson’s disease
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References Ma, Wang, Jiang, Liu, Xie (CR84) 2007; 18
Chan, Suzuki, Yamamoto (CR19) 1997; 16
Lopes, Erhardt, Yao, Cooper (CR81) 1997; 272
Karuppagounder, Madathil, Pandey, Haobam, Rajamma, Mohanakumar (CR66) 2013; 236
Choi, Choi, Lee (CR24) 2011; 409
Quigney, Gorman, Samali (CR109) 2003; 993
Mattison, Roth, Beasley, Tilmont, Handy, Herbert, Longo, Allison, Young, Bryant, Barnard, Ward, Qi, Ingram, De Cabo (CR90) 2012; 489
Shin, Kim, Lee, Ji, Lim (CR123) 2017; 13
Chen, Saunders, Wei, Li, Seth, Chuang (CR20) 1999; 19
Tian, An, Jiang, Duan, Chen, Jiang (CR135) 2006; 80
Antunes, Goes, Boeira, Prigol, Jesse (CR2) 2014; 30
Perier, Bove, Wu, Dehay, Choi, Jackson-Lewis, Rathke-Hartlieb, Bouillet, Strasser, Schulz, Przedborski, Vila (CR104) 2007; 104
Blanchet, Longpre, Bureau, Morissette, Dipaolo, Bronchti, Martinoli (CR7) 2008; 32
Arun, Liu, Donmez (CR3) 2016; 14
Zhang, Ma, Wang, Xie, Xie (CR149) 2011; 61
Hirsch (CR59) 1993; 33
Maggio, Barbier, Corsini (CR87) 1995; 45
Griffioen, Rothman, Ladenheim, Wan, Vranis, Hutchison, Okun, Cadet, Mattson (CR49) 2013; 34
Im, Kim, Uddin, Chae, Lee, Kim, Lee (CR63) 2013; 33
Factor (CR37) 2008; 5
Gandhi, Wood-Kaczmar, Yao, Plun-Favreau, Deas, Klupsch, Downward, Latchman, Tabrizi, Wood, Duchen, Abramov (CR43) 2009; 33
Napolitano, Del Dotto, Petrozzi, Dell’agnello, Bellini, Gambaccini, Bonuccelli (CR98) 1999; 22
Kim, Kim, Rhie, Yoon (CR72) 2015; 24
Radad, Moldzio, Rausch (CR111) 2015; 53
Alvira, Yeste-Velasco, Folch, Verdaguer, Canudas, Pallas, Camins (CR1) 2007; 147
Chen, Jalabi, Shpargel, Farabaugh, Dutta, Yin, Kidd, Bergmann, Stohlman, Trapp (CR23) 2012; 32
Howitz, Bitterman, Cohen, Lamming, Lavu, Wood, Zipkin, Chung, Kisielewski, Zhang, Scherer, Sinclair (CR62) 2003; 425
Lee, Park, Chun, Lee (CR76) 2015; 93
Hatano, Kubo, Sato, Hattori (CR55) 2009; 111
Yang, Gehrke, Imai, Huang, Ouyang, Wang, Yang, Beal, Vogel, Lu (CR145) 2006; 103
Blum, Torch, Lambeng, Nissou, Benabid, Sadoul, Verna (CR10) 2001; 65
Golpich, Rahmani, Mohamed Ibrahim, Dargahi, Mohamed, Raymond, Ahmadiani (CR48) 2015; 51
Hernan, Takkouche, Caamano-Isorna, Gestal-Otero (CR57) 2002; 52
Cao, Qin, Huang, Wang, Yang, Shi, Wu, Zhang, Chen, Wu (CR18) 2017; 319
Piccoli, Sardanelli, Scrima, Ripoli, Quarato, D’aprile, Bellomo, Scacco, De Michele, Filla, Iuso, Boffoli, Capitanio, Papa (CR105) 2008; 33
Lee, Chun, Lee, Jung, Lee (CR75) 2015; 1627
Xiang, Kinoshita, Knudson, Korsmeyer, Schwartzkroin, Morrison (CR143) 1998; 18
Yi, He, Wang (CR146) 2013; 38
Navarro, Boveris (CR99) 2009; 41
Filomeni, Graziani, De Zio, Dini, Centonze, Rotilio, Ciriolo (CR39) 2012; 33
Deas, Plun-Favreau, Wood (CR32) 2009; 1
Franco-Iborra, Vila, Perier (CR41) 2016; 22
De Lau, Breteler (CR30) 2006; 5
Lee, Heo, Lee, Kim, Chung, Im, Chung, Lee (CR77) 2017; 1663
Shavali, Brown-Borg, Ebadi, Porter (CR122) 2008; 439
Valente, Abou-Sleiman, Caputo, Muqit, Harvey, Gispert, Ali, Del Turco, Bentivoglio, Healy, Albanese, Nussbaum, Gonzalez-Maldonado, Deller, Salvi, Cortelli, Gilks, Latchman, Harvey, Dallapiccola, Auburger, Wood (CR138) 2004; 304
Colman, Beasley, Kemnitz, Johnson, Weindruch, Anderson (CR27) 2014; 5
Massano, Bhatia (CR89) 2012; 2
Quinn (CR110) 1995; 310
Tai, Truong (CR129) 2002; 69
Grundlingh, Dargan, El-Zanfaly, Wood (CR50) 2011; 7
Sulzer (CR128) 2007; 30
Tansey, Mccoy, Frank-Cannon (CR130) 2007; 208
Magalingam, Radhakrishnan, Haleagrahara (CR85) 2013; 32
Schneider, Tschopp (CR120) 2000; 74
Federico, Cardaioli, Da Pozzo, Formichi, Gallus, Radi (CR38) 2012; 322
Patten, Germain, Kelly, Slack (CR103) 2010; 20
Khan, Raza, Javed, Ahmad, Khan, Islam, Safhi (CR69) 2012; 22
Gaballah, Zakaria, Elbatsh, Tahoon (CR42) 2016; 251
Heetun, Quigley (CR56) 2012; 18
Lou, Jing, Wei, Shi, Ren, Zhang (CR82) 2014; 79
Tillerson, Caudle, Reveron, Miller (CR136) 2003; 119
Pan, Lai, Ho (CR102) 2010; 1
Weihofen, Thomas, Ostaszewski, Cookson, Selkoe (CR140) 2009; 48
Lee, Cho, Park, Kim, Lee, Kim, Kim, Kim, Chun (CR73) 2008; 250
Stojkovska, Wagner, Morrison (CR126) 2015; 240
Kim, Ju, Ha, Lee, Kim, Oh (CR71) 2012; 35
Rinne, Bracco, Chouza, Dupont, Gershanik, Marti Masso, Montastruc, Marsden (CR115) 1998; 55
Kavitha, Nataraj, Essa, Memon, Manivasagam (CR67) 2013; 206
Zecca, Shima, Stroppolo, Goj, Battiston, Gerbasi, Sarna, Swartz (CR147) 1996; 73
Elkins (CR152) 2017
Nagatsu, Mogi, Ichinose, Togari (CR97) 2000; 58
Kim, Park, Kim, Song, Kwon, Lee, Kitada, Kim, Chung (CR70) 2008; 377
Poewe, Mahlknecht (CR106) 2009; 15
Schuler, Green (CR121) 2001; 29
Goldman, Tanner, Oakes, Bhudhikanok, Gupta, Langston (CR47) 2006; 60
Biskup, Moore (CR6) 2006; 28
Speakman, Mitchell (CR124) 2011; 32
Mythri, Bharath (CR96) 2012; 18
Tarozzi, Morroni, Merlicco, Hrelia, Angeloni, Cantelli-Forti, Hrelia (CR131) 2009; 111
Robakis, Fahn (CR116) 2015; 29
Cadet, Brannock (CR15) 1998; 32
Qiu, Spangler, Wan, Miller, Mattson, So, De Cabo, Zou, Ingram (CR108) 2012; 33
Gao, Simon, Schwarzschild, Ascherio (CR46) 2012; 69
Danielson, Andersen (CR29) 2008; 44
Weintraub, Comella, Horn (CR141) 2008; 14
Liu, Shi, Sun, Zhang, Sun (CR80) 2013; 38
Ramsey, Tansey (CR113) 2014; 256
Colman, Anderson, Johnson, Kastman, Kosmatka, Beasley, Allison, Cruzen, Simmons, Kemnitz, Weindruch (CR26) 2009; 325
Denny, Behari (CR33) 1999; 165
Chen, Jin, Wang, Xu, Deng, Zhao (CR22) 2008; 448
Lv, Hong, Yang, Zhang, Wang, Dong, Zhao, Mu, Meng (CR83) 2012; 2012
Hirsch, Breidert, Rousselet, Hunot, Hartmann, Michel (CR60) 2003; 991
Assaf, Fishbein, Gafni, Keren, Sarne (CR4) 2011; 220
Cotman, Berchtold, Christie (CR28) 2007; 30
Han, Lee, Lee, Kim, Moon, Kim, Hwang (CR53) 2007; 321
Holmer, Keyghobadi, Moore, Menashe, Meshul (CR61) 2005; 57
Magalingam, Radhakrishnan, Haleagrahara (CR86) 2014; 7
Xiao-Qing, Jun-Li, Yu, Jian-Qiang, Pei-Xi (CR144) 2005; 78
Mochizuki, Goto, Mori, Mizuno (CR94) 1996; 137
Hickey, Shi, Van Arsdell, Askalan (CR58) 2011; 70
Nussbaum, Ellis (CR101) 2003; 348
Schapira (CR119) 2008; 7
Bournival, Plouffe, Renaud, Provencher, Martinoli (CR11) 2012; 2012
Calabrese, Bachmann, Bailer, Bolger, Borak, Cai, Cedergreen, Cherian, Chiueh, Clarkson, Cook, Diamond, Doolittle, Dorato, Duke, Feinendegen, Gardner, Hart, Hastings, Hayes, Hoffmann, Ives, Jaworowski, Johnson, Jonas, Kaminski, Keller, Klaunig, Knudsen, Kozumbo, Lettieri, Liu, Maisseu, Maynard, Masoro, Mcclellan, Mehendale, Mothersill, Newlin, Nigg, Oehme, Phalen, Philbert, Rattan, Riviere, Rodricks, Sapolsky, Scott, Seymour, Sinclair, Smith-Sonneborn, Snow, Spear, Stevenson, Thomas, Tubiana, Williams, Mattson (CR16) 2007; 222
Zhang, Cao, Xiong, Wang, Huang, Sun, Wang (CR148) 2010; 31
Block, Hong (CR9) 2007; 35
White, Salzman, Schwid (CR142) 2008; 52
Poole, Thomas, Andrews, Mcbride, Whitworth, Pallanck (CR107) 2008; 105
Salat, Tolosa (CR118) 2013; 3
Lee, Park, Ji, Lee, Lee (CR74) 2014; 92
Rojas, Montes, Rojas, Serrano-Garcia, Rojas-Castaneda (CR117) 2012; 28
Khan, Ahmad, Ishrat, Khan, Hoda, Khuwaja, Raza, Khan, Javed, Vaibhav, Islam (CR68) 2010; 1328
Duan, Mattson (CR34) 1999; 57
Merritt, Rhodes (CR92) 2015; 280
Tatton, Chalmers-Redman, Brown, Tatton (CR132) 2003; 53
Ravenstijn, Drenth, O’neill, Danhof, De Lange (CR114) 2012; 9
Hald, Lotharius (CR51) 2005; 193
Lin, Beal (CR79) 2006; 443
Minault, Madigand, Sabouraud (CR93) 1981; 10
De Rijk, Tzourio, Breteler, Dartigues, Amaducci, Lopez-Pousa, Manubens-Bertran, Alperovitch, Rocca (CR31) 1997; 62
Karlsson, Lindquist (CR65) 2013; 120
Li, Wang, Pei, Liu, Hong (CR78) 2005; 112
Mcnaught, Olanow, Halliwell, Isacson, Jenner (CR91) 2001; 2
Rajeswari (CR112) 2006; 10
Erickson, Voss, Prakash, Basak, Szabo, Chaddock, Kim, Heo, Alves, White, Wojcicki, Mailey, Vieira, Martin, Pence, Woods, Mcauley, Kramer (CR36) 2011; 108
Stocchi, Torti, Fossati (CR125) 2016; 17
Cohen, Tillerson, Smith, Schallert, Zigmond (CR25) 2003; 85
Chen, Yoshida, Saito, Niki (CR21) 2005; 383
Wang, Yu, Pu, Du (CR139) 2014; 53
Muller (CR95) 2015; 75
Tsang, Chung (CR137) 2009; 1792
Baluchnejadmojarad, Rabiee, Zabihnejad, Roghani (CR5) 2017; 1662
Jiang, Zuo, Gu (CR64) 2013; 31
Malagelada, Jin, Jackson-Lewis, Przedborski, Greene (CR88) 2010; 30
Teixeira, Souza, Menezes, Carmo, Fonteles, Gurgel, Lima, Viana, Andrade (CR134) 2013; 110
Hamidi, Faraji, Zarmehri, Haghdoost-Yazdi (CR52) 2012; 34
Gao, Cassidy, Schwarzschild, Rimm, Ascherio (CR45) 2012; 78
Blesa, Trigo-Damas, Quiroga-Varela, Jackson-Lewis (CR8) 2015; 9
Cacabelos (CR14) 2017; 18
Zheng, Ock, Kwon, Suk (CR150) 2008; 8
Taylor, Main, Crack (CR133) 2013; 62
Fleming, Espay (CR40) 2014; 29
Hancock, Martin, Vance, Scott (CR54) 2008; 9
Cannon, Keep, Hua, Richardson, Schallert, Xi (CR17) 2005; 373
Duzel, Van Praag, Sendtner (CR35) 2016; 139
Boveris, Navarro (CR12) 2008; 44
Brochard, Combadiere, Prigent, Laouar, Perrin, Beray-Berthat, Bonduelle, Alvarez-Fischer, Callebert, Launay, Duyckaerts, Flavell, Hirsch, Hunot (CR13) 2009; 119
Zhou, Liu, Niu, Li, He, Wang (CR151) 2005; 18
Gandhi, Vaarmann, Yao, Duchen, Wood, Abramov (CR44) 2012; 7
Strathearn, Yousef, Grace, Roy, Tambe, Ferruzzi, Wu, Simon, Lila, Rochet (CR127) 2014; 1555
Nie, Cao, Zhao (CR100) 2002; 7
D Blum (960_CR10) 2001; 65
KS Mcnaught (960_CR91) 2001; 2
T Hatano (960_CR55) 2009; 111
R Maggio (960_CR87) 1995; 45
EC Hirsch (960_CR59) 1993; 33
M Kavitha (960_CR67) 2013; 206
KI Erickson (960_CR36) 2011; 108
JM Han (960_CR53) 2007; 321
AH Tsang (960_CR137) 2009; 1792
P Schneider (960_CR120) 2000; 74
YY Tian (960_CR135) 2006; 80
F Yi (960_CR146) 2013; 38
K Zhang (960_CR149) 2011; 61
Y Lee (960_CR76) 2015; 93
WG Tatton (960_CR132) 2003; 53
S Franco-Iborra (960_CR41) 2016; 22
M Golpich (960_CR48) 2015; 51
MS Antunes (960_CR2) 2014; 30
ZG Ma (960_CR84) 2007; 18
MC Rijk De (960_CR31) 1997; 62
AC Poole (960_CR107) 2008; 105
D Weintraub (960_CR141) 2008; 14
O Karlsson (960_CR65) 2013; 120
G Nie (960_CR100) 2002; 7
T Muller (960_CR95) 2015; 75
RW Chen (960_CR20) 1999; 19
RL Nussbaum (960_CR101) 2003; 348
RJ Colman (960_CR27) 2014; 5
W Duan (960_CR34) 1999; 57
EC Hirsch (960_CR60) 2003; 991
L Zecca (960_CR147) 1996; 73
CP Ramsey (960_CR113) 2014; 256
ZH Chen (960_CR21) 2005; 383
Y Lee (960_CR75) 2015; 1627
H Mochizuki (960_CR94) 1996; 137
YH Wang (960_CR139) 2014; 53
T Nagatsu (960_CR97) 2000; 58
P Rojas (960_CR117) 2012; 28
EM Valente (960_CR138) 2004; 304
GH Kim (960_CR72) 2015; 24
J Jiang (960_CR64) 2013; 31
T Xiao-Qing (960_CR144) 2005; 78
JM Taylor (960_CR133) 2013; 62
J Bournival (960_CR11) 2012; 2012
HG Kim (960_CR71) 2012; 35
AP Denny (960_CR33) 1999; 165
KB Magalingam (960_CR86) 2014; 7
EJ Calabrese (960_CR16) 2007; 222
Q Cao (960_CR18) 2017; 319
GR Elkins (960_CR152) 2017
D Alvira (960_CR1) 2007; 147
MA Hernan (960_CR57) 2002; 52
R Cacabelos (960_CR14) 2017; 18
M Schuler (960_CR121) 2001; 29
UK Rinne (960_CR115) 1998; 55
MG Tansey (960_CR130) 2007; 208
KB Magalingam (960_CR85) 2013; 32
HJ Lee (960_CR73) 2008; 250
JR Speakman (960_CR124) 2011; 32
N Quinn (960_CR110) 1995; 310
C Malagelada (960_CR88) 2010; 30
Z Chen (960_CR23) 2012; 32
X Gao (960_CR46) 2012; 69
SA Factor (960_CR37) 2008; 5
HK Holmer (960_CR61) 2005; 57
YC Chan (960_CR19) 1997; 16
A Federico (960_CR38) 2012; 322
Y Yang (960_CR145) 2006; 103
T Baluchnejadmojarad (960_CR5) 2017; 1662
K Liu (960_CR80) 2013; 38
AH Schapira (960_CR119) 2008; 7
MH Pan (960_CR102) 2010; 1
HH Gaballah (960_CR42) 2016; 251
DA Patten (960_CR103) 2010; 20
E Duzel (960_CR35) 2016; 139
A Navarro (960_CR99) 2009; 41
S Arun (960_CR3) 2016; 14
KT Howitz (960_CR62) 2003; 425
D Sulzer (960_CR128) 2007; 30
A Tarozzi (960_CR131) 2009; 111
JA Mattison (960_CR90) 2012; 489
LT Zheng (960_CR150) 2008; 8
A Weihofen (960_CR140) 2009; 48
SM Goldman (960_CR47) 2006; 60
MM Khan (960_CR68) 2010; 1328
C Perier (960_CR104) 2007; 104
K Radad (960_CR111) 2015; 53
JS Choi (960_CR24) 2011; 409
SM Fleming (960_CR40) 2014; 29
A Napolitano (960_CR98) 1999; 22
C Piccoli (960_CR105) 2008; 33
MS Shin (960_CR123) 2017; 13
KJ Griffioen (960_CR49) 2013; 34
HQ Chen (960_CR22) 2008; 448
MD Teixeira (960_CR134) 2013; 110
S Biskup (960_CR6) 2006; 28
RJ Colman (960_CR26) 2009; 325
G Qiu (960_CR108) 2012; 33
V Brochard (960_CR13) 2009; 119
JL Cadet (960_CR15) 1998; 32
C Lv (960_CR83) 2012; 2012
J Massano (960_CR89) 2012; 2
HF Zhou (960_CR151) 2005; 18
AD Cohen (960_CR25) 2003; 85
DJ Quigney (960_CR109) 2003; 993
LM Lau De (960_CR30) 2006; 5
H Xiang (960_CR143) 1998; 18
MM Khan (960_CR69) 2012; 22
D Robakis (960_CR116) 2015; 29
Y Lee (960_CR77) 2017; 1663
E Hickey (960_CR58) 2011; 70
FQ Li (960_CR78) 2005; 112
KE Strathearn (960_CR127) 2014; 1555
JR Merritt (960_CR92) 2015; 280
JR Cannon (960_CR17) 2005; 373
J Grundlingh (960_CR50) 2011; 7
RB Mythri (960_CR96) 2012; 18
F Stocchi (960_CR125) 2016; 17
J Blanchet (960_CR7) 2008; 32
X Gao (960_CR45) 2012; 78
W Poewe (960_CR106) 2009; 15
JL Tillerson (960_CR136) 2003; 119
A Rajeswari (960_CR112) 2006; 10
H Lou (960_CR82) 2014; 79
SR Danielson (960_CR29) 2008; 44
AR Im (960_CR63) 2013; 33
D Salat (960_CR118) 2013; 3
ZT Zhang (960_CR148) 2010; 31
MT Lin (960_CR79) 2006; 443
UG Lopes (960_CR81) 1997; 272
P Minault (960_CR93) 1981; 10
KK Tai (960_CR129) 2002; 69
Y Kim (960_CR70) 2008; 377
ML Block (960_CR9) 2007; 35
A Boveris (960_CR12) 2008; 44
PG Ravenstijn (960_CR114) 2012; 9
GA Hamidi (960_CR52) 2012; 34
CW Cotman (960_CR28) 2007; 30
A Hald (960_CR51) 2005; 193
F Assaf (960_CR4) 2011; 220
S Gandhi (960_CR44) 2012; 7
WB White (960_CR142) 2008; 52
E Lee (960_CR74) 2014; 92
S Gandhi (960_CR43) 2009; 33
ZS Heetun (960_CR56) 2012; 18
DB Hancock (960_CR54) 2008; 9
J Blesa (960_CR8) 2015; 9
E Deas (960_CR32) 2009; 1
G Filomeni (960_CR39) 2012; 33
S Shavali (960_CR122) 2008; 439
SS Karuppagounder (960_CR66) 2013; 236
I Stojkovska (960_CR126) 2015; 240
References_xml – volume: 33
  start-page: 625
  year: 2013
  end-page: 635
  ident: CR63
  article-title: Betaine protects against rotenone-induced neurotoxicity in PC12 cells
  publication-title: Cell Mol Neurobiol
  doi: 10.1007/s10571-013-9921-z
– volume: 80
  start-page: 193
  year: 2006
  end-page: 199
  ident: CR135
  article-title: Catalpol protects dopaminergic neurons from LPS-induced neurotoxicity in mesencephalic neuron-glia cultures
  publication-title: Life Sci
  doi: 10.1016/j.lfs.2006.09.010
– volume: 78
  start-page: 61
  year: 2005
  end-page: 66
  ident: CR144
  article-title: Hydrogen peroxide preconditioning protects PC12 cells against apoptosis induced by dopamine
  publication-title: Life Sci
  doi: 10.1016/j.lfs.2005.04.048
– volume: 28
  start-page: 1081
  year: 2012
  end-page: 1088
  ident: CR117
  article-title: Effect of a phytopharmaceutical medicine, Ginko biloba extract 761, in an animal model of Parkinson’s disease: therapeutic perspectives
  publication-title: Nutrition
  doi: 10.1016/j.nut.2012.03.007
– volume: 2012
  start-page: 921941
  year: 2012
  ident: CR11
  article-title: Quercetin and sesamin protect dopaminergic cells from MPP+-induced neuroinflammation in a microglial (N9)-neuronal (PC12) coculture system
  publication-title: Oxid Med Cell Longev
  doi: 10.1155/2012/921941
– volume: 193
  start-page: 279
  year: 2005
  end-page: 290
  ident: CR51
  article-title: Oxidative stress and inflammation in Parkinson’s disease: is there a causal link?
  publication-title: Exp Neurol
  doi: 10.1016/j.expneurol.2005.01.013
– volume: 1
  start-page: 15
  year: 2010
  end-page: 31
  ident: CR102
  article-title: Anti-inflammatory activity of natural dietary flavonoids
  publication-title: Food Funct
  doi: 10.1039/c0fo00103a
– volume: 28
  start-page: 963
  year: 2006
  end-page: 967
  ident: CR6
  article-title: Detrimental deletions: mitochondria, aging and Parkinson’s disease
  publication-title: BioEssays
  doi: 10.1002/bies.20471
– volume: 108
  start-page: 3017
  year: 2011
  end-page: 3022
  ident: CR36
  article-title: Exercise training increases size of hippocampus and improves memory
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1015950108
– volume: 22
  start-page: 24
  year: 1999
  end-page: 29
  ident: CR98
  article-title: Pharmacokinetics and pharmacodynamics of -Dopa after acute and 6-week tolcapone administration in patients with Parkinson’s disease
  publication-title: Clin Neuropharmacol
  doi: 10.1097/00002826-199901000-00005
– volume: 10
  start-page: 157
  year: 2006
  end-page: 161
  ident: CR112
  article-title: Curcumin protects mouse brain from oxidative stress caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  publication-title: Eur Rev Med Pharmacol Sci
– volume: 119
  start-page: 182
  year: 2009
  end-page: 192
  ident: CR13
  article-title: Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease
  publication-title: J Clin Invest
– volume: 22
  start-page: 266
  year: 2016
  end-page: 277
  ident: CR41
  article-title: The Parkinson disease mitochondrial hypothesis: where are we at?
  publication-title: Neuroscientist
  doi: 10.1177/1073858415574600
– volume: 250
  start-page: 109
  year: 2008
  end-page: 115
  ident: CR73
  article-title: Rosmarinic acid protects human dopaminergic neuronal cells against hydrogen peroxide-induced apoptosis
  publication-title: Toxicology
  doi: 10.1016/j.tox.2008.06.010
– volume: 33
  start-page: 767
  year: 2012
  end-page: 785
  ident: CR39
  article-title: Neuroprotection of kaempferol by autophagy in models of rotenone-mediated acute toxicity: possible implications for Parkinson’s disease
  publication-title: Neurobiol Aging
  doi: 10.1016/j.neurobiolaging.2010.05.021
– volume: 30
  start-page: 1166
  year: 2010
  end-page: 1175
  ident: CR88
  article-title: Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson’s disease
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.3944-09.2010
– volume: 9
  start-page: 4
  year: 2012
  ident: CR114
  article-title: Evaluation of blood-brain barrier transport and CNS drug metabolism in diseased and control brain after intravenous -DOPA in a unilateral rat model of Parkinson’s disease
  publication-title: Fluids Barriers CNS
  doi: 10.1186/2045-8118-9-4
– volume: 222
  start-page: 122
  year: 2007
  end-page: 128
  ident: CR16
  article-title: Biological stress response terminology: integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework
  publication-title: Toxicol Appl Pharmacol
  doi: 10.1016/j.taap.2007.02.015
– volume: 409
  start-page: 308
  year: 2011
  end-page: 314
  ident: CR24
  article-title: Caloric restriction improves efficiency and capacity of the mitochondrial electron transport chain in Saccharomyces cerevisiae
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2011.05.008
– volume: 53
  start-page: 562
  year: 2014
  end-page: 570
  ident: CR139
  article-title: Myricitrin alleviates methylglyoxal-induced mitochondrial dysfunction and AGEs/RAGE/NF-kappaB pathway activation in SH-SY5Y cells
  publication-title: J Mol Neurosci
  doi: 10.1007/s12031-013-0222-2
– volume: 348
  start-page: 1356
  year: 2003
  end-page: 1364
  ident: CR101
  article-title: Alzheimer’s disease and Parkinson’s disease
  publication-title: N Engl J Med
  doi: 10.1056/NEJM2003ra020003
– volume: 32
  start-page: 11706
  year: 2012
  end-page: 11715
  ident: CR23
  article-title: Lipopolysaccharide-induced microglial activation and neuroprotection against experimental brain injury is independent of hematogenous TLR4
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.0730-12.2012
– volume: 52
  start-page: 587
  year: 2008
  end-page: 593
  ident: CR142
  article-title: Transtelephonic home blood pressure to assess the monoamine oxidase-B inhibitor rasagiline in Parkinson disease
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.108.115873
– volume: 44
  start-page: 1787
  year: 2008
  end-page: 1794
  ident: CR29
  article-title: Oxidative and nitrative protein modifications in Parkinson’s disease
  publication-title: Free Radic Biol Med
  doi: 10.1016/j.freeradbiomed.2008.03.005
– volume: 30
  start-page: 464
  year: 2007
  end-page: 472
  ident: CR28
  article-title: Exercise builds brain health: key roles of growth factor cascades and inflammation
  publication-title: Trends Neurosci
  doi: 10.1016/j.tins.2007.06.011
– volume: 206
  start-page: 239
  year: 2013
  end-page: 247
  ident: CR67
  article-title: Mangiferin attenuates MPTP induced dopaminergic neurodegeneration and improves motor impairment, redox balance and Bcl-2/Bax expression in experimental Parkinson’s disease mice
  publication-title: Chem Biol Interact
  doi: 10.1016/j.cbi.2013.09.016
– volume: 32
  start-page: 235
  year: 2013
  end-page: 240
  ident: CR85
  article-title: Rutin, a bioflavonoid antioxidant protects rat pheochromocytoma (PC-12) cells against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity
  publication-title: Int J Mol Med
  doi: 10.3892/ijmm.2013.1375
– volume: 325
  start-page: 201
  year: 2009
  end-page: 204
  ident: CR26
  article-title: Caloric restriction delays disease onset and mortality in rhesus monkeys
  publication-title: Science
  doi: 10.1126/science.1173635
– volume: 44
  start-page: 224
  year: 2008
  end-page: 229
  ident: CR12
  article-title: Systemic and mitochondrial adaptive responses to moderate exercise in rodents
  publication-title: Free Radic Biol Med
  doi: 10.1016/j.freeradbiomed.2007.08.015
– volume: 35
  start-page: 1127
  year: 2007
  end-page: 1132
  ident: CR9
  article-title: Chronic microglial activation and progressive dopaminergic neurotoxicity
  publication-title: Biochem Soc Trans
  doi: 10.1042/BST0351127
– volume: 10
  start-page: 3725
  year: 1981
  end-page: 3726
  ident: CR93
  article-title: Pallidostriatal necrosis after Hymenoptera sting. Parkinsonian syndrome
  publication-title: Nouv Presse Med
– volume: 48
  start-page: 2045
  year: 2009
  end-page: 2052
  ident: CR140
  article-title: Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking
  publication-title: Biochemistry
  doi: 10.1021/bi8019178
– volume: 220
  start-page: 194
  year: 2011
  end-page: 201
  ident: CR4
  article-title: Pre- and post-conditioning treatment with an ultra-low dose of Delta9-tetrahydrocannabinol (THC) protects against pentylenetetrazole (PTZ)-induced cognitive damage
  publication-title: Behav Brain Res
  doi: 10.1016/j.bbr.2011.02.005
– volume: 35
  start-page: 1287
  year: 2012
  end-page: 1294
  ident: CR71
  article-title: Acacetin protects dopaminergic cells against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neuroinflammation in vitro and in vivo
  publication-title: Biol Pharm Bull
  doi: 10.1248/bpb.b12-00127
– volume: 5
  start-page: 3557
  year: 2014
  ident: CR27
  article-title: Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys
  publication-title: Nat Commun
  doi: 10.1038/ncomms4557
– volume: 29
  start-page: 433
  year: 2015
  end-page: 441
  ident: CR116
  article-title: Defining the role of the monoamine oxidase-B inhibitors for Parkinson’s disease
  publication-title: CNS Drugs
  doi: 10.1007/s40263-015-0249-8
– volume: 111
  start-page: 1161
  year: 2009
  end-page: 1171
  ident: CR131
  article-title: Sulforaphane as an inducer of glutathione prevents oxidative stress-induced cell death in a dopaminergic-like neuroblastoma cell line
  publication-title: J Neurochem
  doi: 10.1111/j.1471-4159.2009.06394.x
– volume: 62
  start-page: 10
  year: 1997
  end-page: 15
  ident: CR31
  article-title: Prevalence of parkinsonism and Parkinson’s disease in Europe: the EUROPARKINSON Collaborative Study. European Community Concerted Action on the Epidemiology of Parkinson’s disease
  publication-title: J Neurol Neurosurg Psychiatry
  doi: 10.1136/jnnp.62.1.10
– volume: 8
  start-page: 484
  year: 2008
  end-page: 494
  ident: CR150
  article-title: Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity
  publication-title: Int Immunopharmacol
  doi: 10.1016/j.intimp.2007.12.012
– volume: 103
  start-page: 10793
  year: 2006
  end-page: 10798
  ident: CR145
  article-title: Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0602493103
– volume: 1
  start-page: 152
  year: 2009
  end-page: 165
  ident: CR32
  article-title: PINK1 function in health and disease
  publication-title: EMBO Mol Med
  doi: 10.1002/emmm.200900024
– volume: 85
  start-page: 299
  year: 2003
  end-page: 305
  ident: CR25
  article-title: Neuroprotective effects of prior limb use in 6-hydroxydopamine-treated rats: possible role of GDNF
  publication-title: J Neurochem
  doi: 10.1046/j.1471-4159.2003.01657.x
– volume: 120
  start-page: 1623
  year: 2013
  end-page: 1630
  ident: CR65
  article-title: Melanin affinity and its possible role in neurodegeneration
  publication-title: J Neural Transm (Vienna)
  doi: 10.1007/s00702-013-1062-5
– volume: 5
  start-page: 525
  year: 2006
  end-page: 535
  ident: CR30
  article-title: Epidemiology of Parkinson’s disease
  publication-title: Lancet Neurol
  doi: 10.1016/S1474-4422(06)70471-9
– volume: 105
  start-page: 1638
  year: 2008
  end-page: 1643
  ident: CR107
  article-title: The PINK1/Parkin pathway regulates mitochondrial morphology
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0709336105
– volume: 208
  start-page: 1
  year: 2007
  end-page: 25
  ident: CR130
  article-title: Neuroinflammatory mechanisms in Parkinson’s disease: potential environmental triggers, pathways, and targets for early therapeutic intervention
  publication-title: Exp Neurol
  doi: 10.1016/j.expneurol.2007.07.004
– volume: 31
  start-page: 825
  year: 2013
  end-page: 832
  ident: CR64
  article-title: Rapamycin protects the mitochondria against oxidative stress and apoptosis in a rat model of Parkinson’s disease
  publication-title: Int J Mol Med
  doi: 10.3892/ijmm.2013.1280
– volume: 321
  start-page: 249
  year: 2007
  end-page: 256
  ident: CR53
  article-title: Protective effect of sulforaphane against dopaminergic cell death
  publication-title: J Pharmacol Exp Ther
  doi: 10.1124/jpet.106.110866
– volume: 104
  start-page: 8161
  year: 2007
  end-page: 8166
  ident: CR104
  article-title: Two molecular pathways initiate mitochondria-dependent dopaminergic neurodegeneration in experimental Parkinson’s disease
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0609874104
– volume: 33
  start-page: 52
  issue: Suppl 1
  year: 1993
  end-page: 59
  ident: CR59
  article-title: Does oxidative stress participate in nerve cell death in Parkinson’s disease?
  publication-title: Eur Neurol
– volume: 24
  start-page: 325
  year: 2015
  end-page: 340
  ident: CR72
  article-title: The Role of Oxidative Stress in Neurodegenerative Diseases
  publication-title: Exp Neurobiol
  doi: 10.5607/en.2015.24.4.325
– volume: 73
  start-page: 407
  year: 1996
  end-page: 415
  ident: CR147
  article-title: Interaction of neuromelanin and iron in substantia nigra and other areas of human brain
  publication-title: Neuroscience
  doi: 10.1016/0306-4522(96)00047-4
– volume: 14
  start-page: S40
  year: 2008
  end-page: 48
  ident: CR141
  article-title: Parkinson’s disease–Part 1: pathophysiology, symptoms, burden, diagnosis, and assessment
  publication-title: Am J Manag Care
– volume: 7
  start-page: e37564
  year: 2012
  ident: CR44
  article-title: Dopamine induced neurodegeneration in a PINK1 model of Parkinson’s disease
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0037564
– volume: 489
  start-page: 318
  year: 2012
  end-page: 321
  ident: CR90
  article-title: Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
  publication-title: Nature
  doi: 10.1038/nature11432
– volume: 319
  start-page: 80
  year: 2017
  end-page: 90
  ident: CR18
  article-title: Amentoflavone protects dopaminergic neurons in MPTP-induced Parkinson’s disease model mice through PI3K/Akt and ERK signaling pathways
  publication-title: Toxicol Appl Pharmacol
  doi: 10.1016/j.taap.2017.01.019
– volume: 448
  start-page: 175
  year: 2008
  end-page: 179
  ident: CR22
  article-title: Luteolin protects dopaminergic neurons from inflammation-induced injury through inhibition of microglial activation
  publication-title: Neurosci Lett
  doi: 10.1016/j.neulet.2008.10.046
– volume: 58
  start-page: 143
  year: 2000
  end-page: 151
  ident: CR97
  article-title: Cytokines in Parkinson’s disease
  publication-title: J Neural Transm Suppl
– volume: 61
  start-page: 329
  year: 2011
  end-page: 335
  ident: CR149
  article-title: Myricetin attenuated MPP(+)-induced cytotoxicity by anti-oxidation and inhibition of MKK4 and JNK activation in MES23.5 cells
  publication-title: Neuropharmacology
  doi: 10.1016/j.neuropharm.2011.04.021
– volume: 280
  start-page: 62
  year: 2015
  end-page: 71
  ident: CR92
  article-title: Mouse genetic differences in voluntary wheel running, adult hippocampal neurogenesis and learning on the multi-strain-adapted plus water maze
  publication-title: Behav Brain Res
  doi: 10.1016/j.bbr.2014.11.030
– volume: 34
  start-page: 928
  year: 2013
  end-page: 935
  ident: CR49
  article-title: Dietary energy intake modifies brainstem autonomic dysfunction caused by mutant alpha-synuclein
  publication-title: Neurobiol Aging
  doi: 10.1016/j.neurobiolaging.2012.07.008
– volume: 69
  start-page: 380
  year: 2012
  end-page: 384
  ident: CR46
  article-title: Prospective study of statin use and risk of Parkinson disease
  publication-title: Arch Neurol
  doi: 10.1001/archneurol.2011.1060
– volume: 33
  start-page: 2565
  year: 2008
  end-page: 2574
  ident: CR105
  article-title: Mitochondrial respiratory dysfunction in familiar parkinsonism associated with PINK1 mutation
  publication-title: Neurochem Res
  doi: 10.1007/s11064-008-9729-2
– volume: 18
  start-page: 91
  year: 2012
  end-page: 99
  ident: CR96
  article-title: Curcumin: a potential neuroprotective agent in Parkinson’s disease
  publication-title: Curr Pharm Des
  doi: 10.2174/138161212798918995
– year: 2017
  ident: CR152
  publication-title: Parkinson's disease
– volume: 57
  start-page: 100
  year: 2005
  end-page: 112
  ident: CR61
  article-title: Dietary restriction affects striatal glutamate in the MPTP-induced mouse model of nigrostriatal degeneration
  publication-title: Synapse
  doi: 10.1002/syn.20163
– volume: 52
  start-page: 276
  year: 2002
  end-page: 284
  ident: CR57
  article-title: A meta-analysis of coffee drinking, cigarette smoking, and the risk of Parkinson’s disease
  publication-title: Ann Neurol
  doi: 10.1002/ana.10277
– volume: 439
  start-page: 125
  year: 2008
  end-page: 128
  ident: CR122
  article-title: Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells
  publication-title: Neurosci Lett
  doi: 10.1016/j.neulet.2008.05.005
– volume: 383
  start-page: 256
  year: 2005
  end-page: 259
  ident: CR21
  article-title: Adaptation to hydrogen peroxide enhances PC12 cell tolerance against oxidative damage
  publication-title: Neurosci Lett
  doi: 10.1016/j.neulet.2005.04.022
– volume: 38
  start-page: 201
  year: 2013
  end-page: 207
  ident: CR80
  article-title: Therapeutic effects of rapamycin on MPTP-induced Parkinsonism in mice
  publication-title: Neurochem Res
  doi: 10.1007/s11064-012-0909-8
– volume: 110
  start-page: 1
  year: 2013
  end-page: 7
  ident: CR134
  article-title: Catechin attenuates behavioral neurotoxicity induced by 6-OHDA in rats
  publication-title: Pharmacol Biochem Behav
  doi: 10.1016/j.pbb.2013.05.012
– volume: 13
  start-page: 30
  year: 2017
  end-page: 35
  ident: CR123
  article-title: Treadmill exercise alleviates nigrostriatal dopaminergic loss of neurons and fibers in rotenone-induced Parkinson rats
  publication-title: J Exerc Rehabil
  doi: 10.12965/jer.1734906.453
– volume: 1627
  start-page: 233
  year: 2015
  end-page: 242
  ident: CR75
  article-title: Silibinin suppresses astroglial activation in a mouse model of acute Parkinson’s disease by modulating the ERK and JNK signaling pathways
  publication-title: Brain Res
  doi: 10.1016/j.brainres.2015.09.029
– volume: 304
  start-page: 1158
  year: 2004
  end-page: 1160
  ident: CR138
  article-title: Hereditary early-onset Parkinson’s disease caused by mutations in PINK1
  publication-title: Science
  doi: 10.1126/science.1096284
– volume: 33
  start-page: 2398
  year: 2012
  end-page: 2410
  ident: CR108
  article-title: Neuroprotection provided by dietary restriction in rats is further enhanced by reducing glucocortocoids
  publication-title: Neurobiol Aging
  doi: 10.1016/j.neurobiolaging.2011.11.025
– volume: 17
  start-page: 1889
  year: 2016
  end-page: 1902
  ident: CR125
  article-title: Advances in dopamine receptor agonists for the treatment of Parkinson’s disease
  publication-title: Expert Opin Pharmacother
  doi: 10.1080/14656566.2016.1219337
– volume: 993
  start-page: 133
  year: 2003
  end-page: 139
  ident: CR109
  article-title: Heat shock protects PC12 cells against MPP+ toxicity
  publication-title: Brain Res
  doi: 10.1016/j.brainres.2003.09.004
– volume: 7
  start-page: 171
  year: 2002
  end-page: 177
  ident: CR100
  article-title: Protective effects of green tea polyphenols and their major component, (-)-epigallocatechin-3-gallate (EGCG), on 6-hydroxydopamine-induced apoptosis in PC12 cells
  publication-title: Redox Rep
  doi: 10.1179/135100002125000424
– volume: 18
  start-page: 1181
  year: 2007
  end-page: 1185
  ident: CR84
  article-title: Myricetin reduces 6-hydroxydopamine-induced dopamine neuron degeneration in rats
  publication-title: NeuroReport
  doi: 10.1097/WNR.0b013e32821c51fe
– volume: 15
  start-page: S28
  issue: Suppl 4
  year: 2009
  end-page: 32
  ident: CR106
  article-title: The clinical progression of Parkinson’s disease
  publication-title: Parkinsonism Relat Disord
  doi: 10.1016/S1353-8020(09)70831-4
– volume: 34
  start-page: 636
  year: 2012
  end-page: 642
  ident: CR52
  article-title: Prolonged hyperoxia preconditioning attenuates behavioral symptoms of 6-hydroxydopamine-induced Parkinsonism
  publication-title: Neurol Res
  doi: 10.1179/1743132812Y.0000000056
– volume: 18
  start-page: 441
  year: 2005
  end-page: 449
  ident: CR151
  article-title: Triptolide protects dopaminergic neurons from inflammation-mediated damage induced by lipopolysaccharide intranigral injection
  publication-title: Neurobiol Dis
  doi: 10.1016/j.nbd.2004.12.005
– volume: 92
  start-page: 130
  year: 2014
  end-page: 139
  ident: CR74
  article-title: Baicalein attenuates astroglial activation in the 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine-induced Parkinson’s disease model by downregulating the activations of nuclear factor-kappaB, ERK, and JNK
  publication-title: J Neurosci Res
  doi: 10.1002/jnr.23307
– volume: 1555
  start-page: 60
  year: 2014
  end-page: 77
  ident: CR127
  article-title: Neuroprotective effects of anthocyanin- and proanthocyanidin-rich extracts in cellular models of Parkinsons disease
  publication-title: Brain Res
  doi: 10.1016/j.brainres.2014.01.047
– volume: 18
  start-page: 433
  year: 2012
  end-page: 440
  ident: CR56
  article-title: Gastroparesis and Parkinson’s disease: a systematic review
  publication-title: Parkinsonism Relat Disord
  doi: 10.1016/j.parkreldis.2011.12.004
– volume: 236
  start-page: 136
  year: 2013
  end-page: 148
  ident: CR66
  article-title: Quercetin up-regulates mitochondrial complex-I activity to protect against programmed cell death in rotenone model of Parkinson’s disease in rats
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2013.01.032
– volume: 3
  start-page: 255
  year: 2013
  end-page: 269
  ident: CR118
  article-title: Levodopa in the treatment of Parkinson’s disease: current status and new developments
  publication-title: J Parkinsons Dis
– volume: 147
  start-page: 746
  year: 2007
  end-page: 756
  ident: CR1
  article-title: Comparative analysis of the effects of resveratrol in two apoptotic models: inhibition of complex I and potassium deprivation in cerebellar neurons
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2007.04.029
– volume: 373
  start-page: 189
  year: 2005
  end-page: 194
  ident: CR17
  article-title: Thrombin preconditioning provides protection in a 6-hydroxydopamine Parkinson’s disease model
  publication-title: Neurosci Lett
  doi: 10.1016/j.neulet.2004.10.089
– volume: 22
  start-page: 1
  year: 2012
  end-page: 15
  ident: CR69
  article-title: Rutin protects dopaminergic neurons from oxidative stress in an animal model of Parkinson’s disease
  publication-title: Neurotox Res
  doi: 10.1007/s12640-011-9295-2
– volume: 93
  start-page: 755
  year: 2015
  end-page: 765
  ident: CR76
  article-title: Silibinin prevents dopaminergic neuronal loss in a mouse model of Parkinson’s disease via mitochondrial stabilization
  publication-title: J Neurosci Res
  doi: 10.1002/jnr.23544
– volume: 377
  start-page: 975
  year: 2008
  end-page: 980
  ident: CR70
  article-title: PINK1 controls mitochondrial localization of Parkin through direct phosphorylation
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2008.10.104
– volume: 7
  start-page: 205
  year: 2011
  end-page: 212
  ident: CR50
  article-title: 2,4-dinitrophenol (DNP): a weight loss agent with significant acute toxicity and risk of death
  publication-title: J Med Toxicol
  doi: 10.1007/s13181-011-0162-6
– volume: 165
  start-page: 18
  year: 1999
  end-page: 23
  ident: CR33
  article-title: Motor fluctuations in Parkinson’s disease
  publication-title: J Neurol Sci
  doi: 10.1016/S0022-510X(99)00052-0
– volume: 322
  start-page: 254
  year: 2012
  end-page: 262
  ident: CR38
  article-title: Mitochondria, oxidative stress and neurodegeneration
  publication-title: J Neurol Sci
  doi: 10.1016/j.jns.2012.05.030
– volume: 1663
  start-page: 184
  year: 2017
  end-page: 193
  ident: CR77
  article-title: Neuroprotective effects of 2,4-dinitrophenol in an acute model of Parkinson’s disease
  publication-title: Brain Res
  doi: 10.1016/j.brainres.2017.03.018
– volume: 7
  start-page: 49
  year: 2014
  ident: CR86
  article-title: Protective effects of flavonol isoquercitrin, against 6-hydroxy dopamine (6-OHDA)-induced toxicity in PC12 cells
  publication-title: BMC Res Notes
  doi: 10.1186/1756-0500-7-49
– volume: 310
  start-page: 575
  year: 1995
  end-page: 579
  ident: CR110
  article-title: Drug treatment of Parkinson’s disease
  publication-title: BMJ
  doi: 10.1136/bmj.310.6979.575
– volume: 74
  start-page: 281
  year: 2000
  end-page: 286
  ident: CR120
  article-title: Apoptosis induced by death receptors
  publication-title: Pharm Acta Helv
  doi: 10.1016/S0031-6865(99)00038-2
– volume: 139
  start-page: 662
  year: 2016
  end-page: 673
  ident: CR35
  article-title: Can physical exercise in old age improve memory and hippocampal function?
  publication-title: Brain
  doi: 10.1093/brain/awv407
– volume: 19
  start-page: 9654
  year: 1999
  end-page: 9662
  ident: CR20
  article-title: Involvement of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and p53 in neuronal apoptosis: evidence that GAPDH is upregulated by p53
  publication-title: J Neurosci
– volume: 240
  start-page: 1387
  year: 2015
  end-page: 1395
  ident: CR126
  article-title: Parkinson’s disease and enhanced inflammatory response
  publication-title: Exp Biol Med (Maywood)
  doi: 10.1177/1535370215576313
– volume: 62
  start-page: 803
  year: 2013
  end-page: 819
  ident: CR133
  article-title: Neuroinflammation and oxidative stress: co-conspirators in the pathology of Parkinson’s disease
  publication-title: Neurochem Int
  doi: 10.1016/j.neuint.2012.12.016
– volume: 78
  start-page: 1138
  year: 2012
  end-page: 1145
  ident: CR45
  article-title: Habitual intake of dietary flavonoids and risk of Parkinson disease
  publication-title: Neurology
  doi: 10.1212/WNL.0b013e31824f7fc4
– volume: 1792
  start-page: 643
  year: 2009
  end-page: 650
  ident: CR137
  article-title: Oxidative and nitrosative stress in Parkinson’s disease
  publication-title: Biochim Biophys Acta
  doi: 10.1016/j.bbadis.2008.12.006
– volume: 32
  start-page: 117
  year: 1998
  end-page: 131
  ident: CR15
  article-title: Free radicals and the pathobiology of brain dopamine systems
  publication-title: Neurochem Int
  doi: 10.1016/S0197-0186(97)00031-4
– volume: 65
  start-page: 135
  year: 2001
  end-page: 172
  ident: CR10
  article-title: Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson’s disease
  publication-title: Prog Neurobiol
  doi: 10.1016/S0301-0082(01)00003-X
– volume: 991
  start-page: 214
  year: 2003
  end-page: 228
  ident: CR60
  article-title: The role of glial reaction and inflammation in Parkinson’s disease
  publication-title: Ann N Y Acad Sci
  doi: 10.1111/j.1749-6632.2003.tb07478.x
– volume: 30
  start-page: 244
  year: 2007
  end-page: 250
  ident: CR128
  article-title: Multiple hit hypotheses for dopamine neuron loss in Parkinson’s disease
  publication-title: Trends Neurosci
  doi: 10.1016/j.tins.2007.03.009
– volume: 70
  start-page: 10
  year: 2011
  end-page: 14
  ident: CR58
  article-title: Lipopolysaccharide-induced preconditioning against ischemic injury is associated with changes in toll-like receptor 4 expression in the rat developing brain
  publication-title: Pediatr Res
  doi: 10.1203/PDR.0b013e31821d02aa
– volume: 79
  start-page: 380
  year: 2014
  end-page: 388
  ident: CR82
  article-title: Naringenin protects against 6-OHDA-induced neurotoxicity via activation of the Nrf2/ARE signaling pathway
  publication-title: Neuropharmacology
  doi: 10.1016/j.neuropharm.2013.11.026
– volume: 33
  start-page: 627
  year: 2009
  end-page: 638
  ident: CR43
  article-title: PINK1-associated Parkinson’s disease is caused by neuronal vulnerability to calcium-induced cell death
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2009.02.013
– volume: 69
  start-page: 559
  year: 2002
  end-page: 566
  ident: CR129
  article-title: Activation of adenosine triphosphate-sensitive potassium channels confers protection against rotenone-induced cell death: therapeutic implications for Parkinson’s disease
  publication-title: J Neurosci Res
  doi: 10.1002/jnr.10309
– volume: 5
  start-page: 164
  year: 2008
  end-page: 180
  ident: CR37
  article-title: Current status of symptomatic medical therapy in Parkinson’s disease
  publication-title: Neurotherapeutics
  doi: 10.1016/j.nurt.2007.12.001
– volume: 38
  start-page: 1747
  year: 2013
  end-page: 1757
  ident: CR146
  article-title: Lycopene protects against MPP(+)-induced cytotoxicity by maintaining mitochondrial function in SH-SY5Y cells
  publication-title: Neurochem Res
  doi: 10.1007/s11064-013-1079-z
– volume: 251
  start-page: 10
  year: 2016
  end-page: 16
  ident: CR42
  article-title: Modulatory effects of resveratrol on endoplasmic reticulum stress-associated apoptosis and oxido-inflammatory markers in a rat model of rotenone-induced Parkinson’s disease
  publication-title: Chem Biol Interact
  doi: 10.1016/j.cbi.2016.03.023
– volume: 41
  start-page: 517
  year: 2009
  end-page: 521
  ident: CR99
  article-title: Brain mitochondrial dysfunction and oxidative damage in Parkinson’s disease
  publication-title: J Bioenerg Biomembr
  doi: 10.1007/s10863-009-9250-6
– volume: 18
  start-page: 551
  year: 2017
  ident: CR14
  article-title: Parkinson’s disease: from pathogenesis to pharmacogenomics
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms18030551
– volume: 20
  start-page: S357
  issue: Suppl 2
  year: 2010
  end-page: 367
  ident: CR103
  article-title: Reactive oxygen species: stuck in the middle of neurodegeneration
  publication-title: J Alzheimers Dis
  doi: 10.3233/JAD-2010-100498
– volume: 137
  start-page: 120
  year: 1996
  end-page: 123
  ident: CR94
  article-title: Histochemical detection of apoptosis in Parkinson’s disease
  publication-title: J Neurol Sci
  doi: 10.1016/0022-510X(95)00336-Z
– volume: 1328
  start-page: 139
  year: 2010
  end-page: 151
  ident: CR68
  article-title: Resveratrol attenuates 6-hydroxydopamine-induced oxidative damage and dopamine depletion in rat model of Parkinson’s disease
  publication-title: Brain Res
  doi: 10.1016/j.brainres.2010.02.031
– volume: 18
  start-page: 1363
  year: 1998
  end-page: 1373
  ident: CR143
  article-title: Bax involvement in p53-mediated neuronal cell death
  publication-title: J Neurosci
– volume: 29
  start-page: 1466
  year: 2014
  ident: CR40
  article-title: Cinnamon in a mouse model of PD: Khasnavis S, Pahan K. Cinnamon protects dopaminergic neurons in a mouse model of Parkinson’s disease. J Neuroimmune Pharmacol 2014;9:569-581
  publication-title: Mov Disord
  doi: 10.1002/mds.26034
– volume: 53
  start-page: S61
  issue: Suppl 3
  year: 2003
  end-page: S70
  ident: CR132
  article-title: Apoptosis in Parkinson’s disease: signals for neuronal degradation
  publication-title: Ann Neurol
  doi: 10.1002/ana.10489
– volume: 31
  start-page: 900
  year: 2010
  end-page: 906
  ident: CR148
  article-title: Morin exerts neuroprotective actions in Parkinson disease models in vitro and in vivo
  publication-title: Acta Pharmacol Sin
  doi: 10.1038/aps.2010.77
– volume: 29
  start-page: 684
  year: 2001
  end-page: 688
  ident: CR121
  article-title: Mechanisms of p53-dependent apoptosis
  publication-title: Biochem Soc Trans
  doi: 10.1042/bst0290684
– volume: 14
  start-page: 143
  year: 2016
  end-page: 154
  ident: CR3
  article-title: Mitochondrial biology and neurological diseases
  publication-title: Curr Neuropharmacol
  doi: 10.2174/1570159X13666150703154541
– volume: 272
  start-page: 12893
  year: 1997
  end-page: 12896
  ident: CR81
  article-title: p53-dependent induction of apoptosis by proteasome inhibitors
  publication-title: J Biol Chem
  doi: 10.1074/jbc.272.20.12893
– volume: 55
  start-page: 23
  issue: Suppl 1
  year: 1998
  end-page: 30
  ident: CR115
  article-title: Early treatment of Parkinson’s disease with cabergoline delays the onset of motor complications. Results of a double-blind levodopa controlled trial. The PKDS009 Study Group
  publication-title: Drugs
  doi: 10.2165/00003495-199855001-00004
– volume: 9
  start-page: 249
  year: 2008
  end-page: 262
  ident: CR54
  article-title: Nitric oxide synthase genes and their interactions with environmental factors in Parkinson’s disease
  publication-title: Neurogenetics
  doi: 10.1007/s10048-008-0137-1
– volume: 443
  start-page: 787
  year: 2006
  end-page: 795
  ident: CR79
  article-title: Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
  publication-title: Nature
  doi: 10.1038/nature05292
– volume: 30
  start-page: 1415
  year: 2014
  end-page: 1422
  ident: CR2
  article-title: Protective effect of hesperidin in a model of Parkinson’s disease induced by 6-hydroxydopamine in aged mice
  publication-title: Nutrition
  doi: 10.1016/j.nut.2014.03.024
– volume: 60
  start-page: 65
  year: 2006
  end-page: 72
  ident: CR47
  article-title: Head injury and Parkinson’s disease risk in twins
  publication-title: Ann Neurol
  doi: 10.1002/ana.20882
– volume: 256
  start-page: 126
  year: 2014
  end-page: 132
  ident: CR113
  article-title: A survey from 2012 of evidence for the role of neuroinflammation in neurotoxin animal models of Parkinson’s disease and potential molecular targets
  publication-title: Exp Neurol
  doi: 10.1016/j.expneurol.2013.05.014
– volume: 425
  start-page: 191
  year: 2003
  end-page: 196
  ident: CR62
  article-title: Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
  publication-title: Nature
  doi: 10.1038/nature01960
– volume: 111
  start-page: 1075
  year: 2009
  end-page: 1093
  ident: CR55
  article-title: Pathogenesis of familial Parkinson’s disease: new insights based on monogenic forms of Parkinson’s disease
  publication-title: J Neurochem
  doi: 10.1111/j.1471-4159.2009.06403.x
– volume: 1662
  start-page: 23
  year: 2017
  end-page: 30
  ident: CR5
  article-title: Ellagic acid exerts protective effect in intrastriatal 6-hydroxydopamine rat model of Parkinson’s disease: possible involvement of ERbeta/Nrf2/HO-1 signaling
  publication-title: Brain Res
  doi: 10.1016/j.brainres.2017.02.021
– volume: 9
  start-page: 91
  year: 2015
  ident: CR8
  article-title: Oxidative stress and Parkinson’s disease
  publication-title: Front Neuroanat
– volume: 2
  start-page: a008870
  year: 2012
  ident: CR89
  article-title: Clinical approach to Parkinson’s disease: features, diagnosis, and principles of management
  publication-title: Cold Spring Harb Perspect Med
  doi: 10.1101/cshperspect.a008870
– volume: 51
  start-page: 313
  year: 2015
  end-page: 330
  ident: CR48
  article-title: Preconditioning as a potential strategy for the prevention of Parkinson’s disease
  publication-title: Mol Neurobiol
  doi: 10.1007/s12035-014-8689-6
– volume: 119
  start-page: 899
  year: 2003
  end-page: 911
  ident: CR136
  article-title: Exercise induces behavioral recovery and attenuates neurochemical deficits in rodent models of Parkinson’s disease
  publication-title: Neuroscience
  doi: 10.1016/S0306-4522(03)00096-4
– volume: 2
  start-page: 589
  year: 2001
  end-page: 594
  ident: CR91
  article-title: Failure of the ubiquitin-proteasome system in Parkinson’s disease
  publication-title: Nat Rev Neurosci
  doi: 10.1038/35086067
– volume: 45
  start-page: 133
  year: 1995
  end-page: 136
  ident: CR87
  article-title: Apomorphine continuous stimulation in Parkinson’s disease: receptor desensitization as a possible mechanism of reduced motor response
  publication-title: J Neural Transm Suppl
– volume: 2012
  start-page: 928643
  year: 2012
  ident: CR83
  article-title: Effect of quercetin in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced mouse model of Parkinson’s disease
  publication-title: Evid Complement Altern Med
– volume: 53
  start-page: 250
  year: 2015
  end-page: 261
  ident: CR111
  article-title: Rapamycin protects dopaminergic neurons against rotenone-induced cell death in primary mesencephalic cell culture
  publication-title: Folia Neuropathol
  doi: 10.5114/fn.2015.54426
– volume: 7
  start-page: 97
  year: 2008
  end-page: 109
  ident: CR119
  article-title: Mitochondria in the aetiology and pathogenesis of Parkinson’s disease
  publication-title: Lancet Neurol
  doi: 10.1016/S1474-4422(07)70327-7
– volume: 112
  start-page: 331
  year: 2005
  end-page: 347
  ident: CR78
  article-title: Inhibition of microglial activation by the herbal flavonoid baicalein attenuates inflammation-mediated degeneration of dopaminergic neurons
  publication-title: J Neural Transm (Vienna)
  doi: 10.1007/s00702-004-0213-0
– volume: 75
  start-page: 157
  year: 2015
  end-page: 174
  ident: CR95
  article-title: Catechol-O-methyltransferase inhibitors in Parkinson’s disease
  publication-title: Drugs
  doi: 10.1007/s40265-014-0343-0
– volume: 16
  start-page: 229
  year: 1997
  end-page: 235
  ident: CR19
  article-title: Dietary, anthropometric, hematological and biochemical assessment of the nutritional status of centenarians and elderly people in Okinawa, Japan
  publication-title: J Am Coll Nutr
  doi: 10.1080/07315724.1997.10718679
– volume: 32
  start-page: 159
  year: 2011
  end-page: 221
  ident: CR124
  article-title: Caloric restriction
  publication-title: Mol Aspects Med
  doi: 10.1016/j.mam.2011.07.001
– volume: 32
  start-page: 1243
  year: 2008
  end-page: 1250
  ident: CR7
  article-title: Resveratrol, a red wine polyphenol, protects dopaminergic neurons in MPTP-treated mice
  publication-title: Prog Neuropsychopharmacol Biol Psychiatry
  doi: 10.1016/j.pnpbp.2008.03.024
– volume: 57
  start-page: 195
  year: 1999
  end-page: 206
  ident: CR34
  article-title: Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson’s disease
  publication-title: J Neurosci Res
  doi: 10.1002/(SICI)1097-4547(19990715)57:2<195::AID-JNR5>3.0.CO;2-P
– volume: 16
  start-page: 229
  year: 1997
  ident: 960_CR19
  publication-title: J Am Coll Nutr
  doi: 10.1080/07315724.1997.10718679
– volume: 32
  start-page: 159
  year: 2011
  ident: 960_CR124
  publication-title: Mol Aspects Med
  doi: 10.1016/j.mam.2011.07.001
– volume: 18
  start-page: 551
  year: 2017
  ident: 960_CR14
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms18030551
– volume: 33
  start-page: 2565
  year: 2008
  ident: 960_CR105
  publication-title: Neurochem Res
  doi: 10.1007/s11064-008-9729-2
– volume: 8
  start-page: 484
  year: 2008
  ident: 960_CR150
  publication-title: Int Immunopharmacol
  doi: 10.1016/j.intimp.2007.12.012
– volume: 30
  start-page: 1415
  year: 2014
  ident: 960_CR2
  publication-title: Nutrition
  doi: 10.1016/j.nut.2014.03.024
– volume: 9
  start-page: 249
  year: 2008
  ident: 960_CR54
  publication-title: Neurogenetics
  doi: 10.1007/s10048-008-0137-1
– volume: 991
  start-page: 214
  year: 2003
  ident: 960_CR60
  publication-title: Ann N Y Acad Sci
  doi: 10.1111/j.1749-6632.2003.tb07478.x
– volume: 34
  start-page: 636
  year: 2012
  ident: 960_CR52
  publication-title: Neurol Res
  doi: 10.1179/1743132812Y.0000000056
– volume: 119
  start-page: 899
  year: 2003
  ident: 960_CR136
  publication-title: Neuroscience
  doi: 10.1016/S0306-4522(03)00096-4
– volume: 38
  start-page: 1747
  year: 2013
  ident: 960_CR146
  publication-title: Neurochem Res
  doi: 10.1007/s11064-013-1079-z
– volume: 373
  start-page: 189
  year: 2005
  ident: 960_CR17
  publication-title: Neurosci Lett
  doi: 10.1016/j.neulet.2004.10.089
– volume: 112
  start-page: 331
  year: 2005
  ident: 960_CR78
  publication-title: J Neural Transm (Vienna)
  doi: 10.1007/s00702-004-0213-0
– volume: 73
  start-page: 407
  year: 1996
  ident: 960_CR147
  publication-title: Neuroscience
  doi: 10.1016/0306-4522(96)00047-4
– volume: 33
  start-page: 767
  year: 2012
  ident: 960_CR39
  publication-title: Neurobiol Aging
  doi: 10.1016/j.neurobiolaging.2010.05.021
– volume: 31
  start-page: 825
  year: 2013
  ident: 960_CR64
  publication-title: Int J Mol Med
  doi: 10.3892/ijmm.2013.1280
– volume: 1328
  start-page: 139
  year: 2010
  ident: 960_CR68
  publication-title: Brain Res
  doi: 10.1016/j.brainres.2010.02.031
– volume: 139
  start-page: 662
  year: 2016
  ident: 960_CR35
  publication-title: Brain
  doi: 10.1093/brain/awv407
– volume: 105
  start-page: 1638
  year: 2008
  ident: 960_CR107
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0709336105
– volume: 7
  start-page: 205
  year: 2011
  ident: 960_CR50
  publication-title: J Med Toxicol
  doi: 10.1007/s13181-011-0162-6
– volume: 48
  start-page: 2045
  year: 2009
  ident: 960_CR140
  publication-title: Biochemistry
  doi: 10.1021/bi8019178
– volume: 165
  start-page: 18
  year: 1999
  ident: 960_CR33
  publication-title: J Neurol Sci
  doi: 10.1016/S0022-510X(99)00052-0
– volume: 22
  start-page: 266
  year: 2016
  ident: 960_CR41
  publication-title: Neuroscientist
  doi: 10.1177/1073858415574600
– volume: 18
  start-page: 1181
  year: 2007
  ident: 960_CR84
  publication-title: NeuroReport
  doi: 10.1097/WNR.0b013e32821c51fe
– volume: 236
  start-page: 136
  year: 2013
  ident: 960_CR66
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2013.01.032
– volume: 69
  start-page: 559
  year: 2002
  ident: 960_CR129
  publication-title: J Neurosci Res
  doi: 10.1002/jnr.10309
– volume: 321
  start-page: 249
  year: 2007
  ident: 960_CR53
  publication-title: J Pharmacol Exp Ther
  doi: 10.1124/jpet.106.110866
– volume: 53
  start-page: 562
  year: 2014
  ident: 960_CR139
  publication-title: J Mol Neurosci
  doi: 10.1007/s12031-013-0222-2
– volume: 32
  start-page: 1243
  year: 2008
  ident: 960_CR7
  publication-title: Prog Neuropsychopharmacol Biol Psychiatry
  doi: 10.1016/j.pnpbp.2008.03.024
– volume: 35
  start-page: 1127
  year: 2007
  ident: 960_CR9
  publication-title: Biochem Soc Trans
  doi: 10.1042/BST0351127
– volume: 55
  start-page: 23
  issue: Suppl 1
  year: 1998
  ident: 960_CR115
  publication-title: Drugs
  doi: 10.2165/00003495-199855001-00004
– volume: 18
  start-page: 1363
  year: 1998
  ident: 960_CR143
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.18-04-01363.1998
– volume: 34
  start-page: 928
  year: 2013
  ident: 960_CR49
  publication-title: Neurobiol Aging
  doi: 10.1016/j.neurobiolaging.2012.07.008
– volume: 79
  start-page: 380
  year: 2014
  ident: 960_CR82
  publication-title: Neuropharmacology
  doi: 10.1016/j.neuropharm.2013.11.026
– volume: 74
  start-page: 281
  year: 2000
  ident: 960_CR120
  publication-title: Pharm Acta Helv
  doi: 10.1016/S0031-6865(99)00038-2
– volume: 1555
  start-page: 60
  year: 2014
  ident: 960_CR127
  publication-title: Brain Res
  doi: 10.1016/j.brainres.2014.01.047
– volume: 22
  start-page: 24
  year: 1999
  ident: 960_CR98
  publication-title: Clin Neuropharmacol
  doi: 10.1097/00002826-199901000-00005
– volume: 7
  start-page: 171
  year: 2002
  ident: 960_CR100
  publication-title: Redox Rep
  doi: 10.1179/135100002125000424
– volume: 110
  start-page: 1
  year: 2013
  ident: 960_CR134
  publication-title: Pharmacol Biochem Behav
  doi: 10.1016/j.pbb.2013.05.012
– volume: 111
  start-page: 1161
  year: 2009
  ident: 960_CR131
  publication-title: J Neurochem
  doi: 10.1111/j.1471-4159.2009.06394.x
– volume: 31
  start-page: 900
  year: 2010
  ident: 960_CR148
  publication-title: Acta Pharmacol Sin
  doi: 10.1038/aps.2010.77
– volume: 78
  start-page: 61
  year: 2005
  ident: 960_CR144
  publication-title: Life Sci
  doi: 10.1016/j.lfs.2005.04.048
– volume: 251
  start-page: 10
  year: 2016
  ident: 960_CR42
  publication-title: Chem Biol Interact
  doi: 10.1016/j.cbi.2016.03.023
– volume: 18
  start-page: 433
  year: 2012
  ident: 960_CR56
  publication-title: Parkinsonism Relat Disord
  doi: 10.1016/j.parkreldis.2011.12.004
– volume: 69
  start-page: 380
  year: 2012
  ident: 960_CR46
  publication-title: Arch Neurol
  doi: 10.1001/archneurol.2011.1060
– volume: 7
  start-page: e37564
  year: 2012
  ident: 960_CR44
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0037564
– volume: 14
  start-page: 143
  year: 2016
  ident: 960_CR3
  publication-title: Curr Neuropharmacol
  doi: 10.2174/1570159X13666150703154541
– volume: 53
  start-page: 250
  year: 2015
  ident: 960_CR111
  publication-title: Folia Neuropathol
  doi: 10.5114/fn.2015.54426
– volume: 61
  start-page: 329
  year: 2011
  ident: 960_CR149
  publication-title: Neuropharmacology
  doi: 10.1016/j.neuropharm.2011.04.021
– volume: 5
  start-page: 164
  year: 2008
  ident: 960_CR37
  publication-title: Neurotherapeutics
  doi: 10.1016/j.nurt.2007.12.001
– volume: 111
  start-page: 1075
  year: 2009
  ident: 960_CR55
  publication-title: J Neurochem
  doi: 10.1111/j.1471-4159.2009.06403.x
– volume: 377
  start-page: 975
  year: 2008
  ident: 960_CR70
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2008.10.104
– volume: 2
  start-page: a008870
  year: 2012
  ident: 960_CR89
  publication-title: Cold Spring Harb Perspect Med
  doi: 10.1101/cshperspect.a008870
– volume: 78
  start-page: 1138
  year: 2012
  ident: 960_CR45
  publication-title: Neurology
  doi: 10.1212/WNL.0b013e31824f7fc4
– volume: 10
  start-page: 3725
  year: 1981
  ident: 960_CR93
  publication-title: Nouv Presse Med
– volume: 220
  start-page: 194
  year: 2011
  ident: 960_CR4
  publication-title: Behav Brain Res
  doi: 10.1016/j.bbr.2011.02.005
– volume: 62
  start-page: 803
  year: 2013
  ident: 960_CR133
  publication-title: Neurochem Int
  doi: 10.1016/j.neuint.2012.12.016
– volume: 5
  start-page: 3557
  year: 2014
  ident: 960_CR27
  publication-title: Nat Commun
  doi: 10.1038/ncomms4557
– volume: 108
  start-page: 3017
  year: 2011
  ident: 960_CR36
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1015950108
– volume: 425
  start-page: 191
  year: 2003
  ident: 960_CR62
  publication-title: Nature
  doi: 10.1038/nature01960
– volume: 1792
  start-page: 643
  year: 2009
  ident: 960_CR137
  publication-title: Biochim Biophys Acta
  doi: 10.1016/j.bbadis.2008.12.006
– volume: 3
  start-page: 255
  year: 2013
  ident: 960_CR118
  publication-title: J Parkinsons Dis
  doi: 10.3233/JPD-130186
– volume: 119
  start-page: 182
  year: 2009
  ident: 960_CR13
  publication-title: J Clin Invest
– volume: 70
  start-page: 10
  year: 2011
  ident: 960_CR58
  publication-title: Pediatr Res
  doi: 10.1203/PDR.0b013e31821d02aa
– volume: 147
  start-page: 746
  year: 2007
  ident: 960_CR1
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2007.04.029
– volume: 52
  start-page: 587
  year: 2008
  ident: 960_CR142
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.108.115873
– volume: 319
  start-page: 80
  year: 2017
  ident: 960_CR18
  publication-title: Toxicol Appl Pharmacol
  doi: 10.1016/j.taap.2017.01.019
– volume: 33
  start-page: 627
  year: 2009
  ident: 960_CR43
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2009.02.013
– volume: 304
  start-page: 1158
  year: 2004
  ident: 960_CR138
  publication-title: Science
  doi: 10.1126/science.1096284
– volume: 29
  start-page: 1466
  year: 2014
  ident: 960_CR40
  publication-title: Mov Disord
  doi: 10.1002/mds.26034
– volume: 30
  start-page: 464
  year: 2007
  ident: 960_CR28
  publication-title: Trends Neurosci
  doi: 10.1016/j.tins.2007.06.011
– volume: 75
  start-page: 157
  year: 2015
  ident: 960_CR95
  publication-title: Drugs
  doi: 10.1007/s40265-014-0343-0
– volume: 30
  start-page: 244
  year: 2007
  ident: 960_CR128
  publication-title: Trends Neurosci
  doi: 10.1016/j.tins.2007.03.009
– volume: 28
  start-page: 963
  year: 2006
  ident: 960_CR6
  publication-title: BioEssays
  doi: 10.1002/bies.20471
– volume: 1662
  start-page: 23
  year: 2017
  ident: 960_CR5
  publication-title: Brain Res
  doi: 10.1016/j.brainres.2017.02.021
– volume: 193
  start-page: 279
  year: 2005
  ident: 960_CR51
  publication-title: Exp Neurol
  doi: 10.1016/j.expneurol.2005.01.013
– volume: 57
  start-page: 100
  year: 2005
  ident: 960_CR61
  publication-title: Synapse
  doi: 10.1002/syn.20163
– volume: 92
  start-page: 130
  year: 2014
  ident: 960_CR74
  publication-title: J Neurosci Res
  doi: 10.1002/jnr.23307
– volume: 489
  start-page: 318
  year: 2012
  ident: 960_CR90
  publication-title: Nature
  doi: 10.1038/nature11432
– volume: 240
  start-page: 1387
  year: 2015
  ident: 960_CR126
  publication-title: Exp Biol Med (Maywood)
  doi: 10.1177/1535370215576313
– volume: 2012
  start-page: 921941
  year: 2012
  ident: 960_CR11
  publication-title: Oxid Med Cell Longev
  doi: 10.1155/2012/921941
– volume: 409
  start-page: 308
  year: 2011
  ident: 960_CR24
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2011.05.008
– volume: 17
  start-page: 1889
  year: 2016
  ident: 960_CR125
  publication-title: Expert Opin Pharmacother
  doi: 10.1080/14656566.2016.1219337
– volume: 60
  start-page: 65
  year: 2006
  ident: 960_CR47
  publication-title: Ann Neurol
  doi: 10.1002/ana.20882
– volume: 120
  start-page: 1623
  year: 2013
  ident: 960_CR65
  publication-title: J Neural Transm (Vienna)
  doi: 10.1007/s00702-013-1062-5
– volume: 5
  start-page: 525
  year: 2006
  ident: 960_CR30
  publication-title: Lancet Neurol
  doi: 10.1016/S1474-4422(06)70471-9
– volume: 348
  start-page: 1356
  year: 2003
  ident: 960_CR101
  publication-title: N Engl J Med
  doi: 10.1056/NEJM2003ra020003
– volume: 32
  start-page: 11706
  year: 2012
  ident: 960_CR23
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.0730-12.2012
– volume-title: Parkinson's disease
  year: 2017
  ident: 960_CR152
– volume: 14
  start-page: S40
  year: 2008
  ident: 960_CR141
  publication-title: Am J Manag Care
– volume: 20
  start-page: S357
  issue: Suppl 2
  year: 2010
  ident: 960_CR103
  publication-title: J Alzheimers Dis
  doi: 10.3233/JAD-2010-100498
– volume: 33
  start-page: 2398
  year: 2012
  ident: 960_CR108
  publication-title: Neurobiol Aging
  doi: 10.1016/j.neurobiolaging.2011.11.025
– volume: 2
  start-page: 589
  year: 2001
  ident: 960_CR91
  publication-title: Nat Rev Neurosci
  doi: 10.1038/35086067
– volume: 250
  start-page: 109
  year: 2008
  ident: 960_CR73
  publication-title: Toxicology
  doi: 10.1016/j.tox.2008.06.010
– volume: 383
  start-page: 256
  year: 2005
  ident: 960_CR21
  publication-title: Neurosci Lett
  doi: 10.1016/j.neulet.2005.04.022
– volume: 18
  start-page: 441
  year: 2005
  ident: 960_CR151
  publication-title: Neurobiol Dis
  doi: 10.1016/j.nbd.2004.12.005
– volume: 80
  start-page: 193
  year: 2006
  ident: 960_CR135
  publication-title: Life Sci
  doi: 10.1016/j.lfs.2006.09.010
– volume: 33
  start-page: 625
  year: 2013
  ident: 960_CR63
  publication-title: Cell Mol Neurobiol
  doi: 10.1007/s10571-013-9921-z
– volume: 256
  start-page: 126
  year: 2014
  ident: 960_CR113
  publication-title: Exp Neurol
  doi: 10.1016/j.expneurol.2013.05.014
– volume: 439
  start-page: 125
  year: 2008
  ident: 960_CR122
  publication-title: Neurosci Lett
  doi: 10.1016/j.neulet.2008.05.005
– volume: 208
  start-page: 1
  year: 2007
  ident: 960_CR130
  publication-title: Exp Neurol
  doi: 10.1016/j.expneurol.2007.07.004
– volume: 1627
  start-page: 233
  year: 2015
  ident: 960_CR75
  publication-title: Brain Res
  doi: 10.1016/j.brainres.2015.09.029
– volume: 310
  start-page: 575
  year: 1995
  ident: 960_CR110
  publication-title: BMJ
  doi: 10.1136/bmj.310.6979.575
– volume: 448
  start-page: 175
  year: 2008
  ident: 960_CR22
  publication-title: Neurosci Lett
  doi: 10.1016/j.neulet.2008.10.046
– volume: 10
  start-page: 157
  year: 2006
  ident: 960_CR112
  publication-title: Eur Rev Med Pharmacol Sci
– volume: 93
  start-page: 755
  year: 2015
  ident: 960_CR76
  publication-title: J Neurosci Res
  doi: 10.1002/jnr.23544
– volume: 7
  start-page: 97
  year: 2008
  ident: 960_CR119
  publication-title: Lancet Neurol
  doi: 10.1016/S1474-4422(07)70327-7
– volume: 9
  start-page: 4
  year: 2012
  ident: 960_CR114
  publication-title: Fluids Barriers CNS
  doi: 10.1186/2045-8118-9-4
– volume: 7
  start-page: 49
  year: 2014
  ident: 960_CR86
  publication-title: BMC Res Notes
  doi: 10.1186/1756-0500-7-49
– volume: 13
  start-page: 30
  year: 2017
  ident: 960_CR123
  publication-title: J Exerc Rehabil
  doi: 10.12965/jer.1734906.453
– volume: 322
  start-page: 254
  year: 2012
  ident: 960_CR38
  publication-title: J Neurol Sci
  doi: 10.1016/j.jns.2012.05.030
– volume: 65
  start-page: 135
  year: 2001
  ident: 960_CR10
  publication-title: Prog Neurobiol
  doi: 10.1016/S0301-0082(01)00003-X
– volume: 53
  start-page: S61
  issue: Suppl 3
  year: 2003
  ident: 960_CR132
  publication-title: Ann Neurol
  doi: 10.1002/ana.10489
– volume: 206
  start-page: 239
  year: 2013
  ident: 960_CR67
  publication-title: Chem Biol Interact
  doi: 10.1016/j.cbi.2013.09.016
– volume: 1663
  start-page: 184
  year: 2017
  ident: 960_CR77
  publication-title: Brain Res
  doi: 10.1016/j.brainres.2017.03.018
– volume: 35
  start-page: 1287
  year: 2012
  ident: 960_CR71
  publication-title: Biol Pharm Bull
  doi: 10.1248/bpb.b12-00127
– volume: 280
  start-page: 62
  year: 2015
  ident: 960_CR92
  publication-title: Behav Brain Res
  doi: 10.1016/j.bbr.2014.11.030
– volume: 103
  start-page: 10793
  year: 2006
  ident: 960_CR145
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0602493103
– volume: 24
  start-page: 325
  year: 2015
  ident: 960_CR72
  publication-title: Exp Neurobiol
  doi: 10.5607/en.2015.24.4.325
– volume: 32
  start-page: 117
  year: 1998
  ident: 960_CR15
  publication-title: Neurochem Int
  doi: 10.1016/S0197-0186(97)00031-4
– volume: 62
  start-page: 10
  year: 1997
  ident: 960_CR31
  publication-title: J Neurol Neurosurg Psychiatry
  doi: 10.1136/jnnp.62.1.10
– volume: 137
  start-page: 120
  year: 1996
  ident: 960_CR94
  publication-title: J Neurol Sci
  doi: 10.1016/0022-510X(95)00336-Z
– volume: 2012
  start-page: 928643
  year: 2012
  ident: 960_CR83
  publication-title: Evid Complement Altern Med
– volume: 272
  start-page: 12893
  year: 1997
  ident: 960_CR81
  publication-title: J Biol Chem
  doi: 10.1074/jbc.272.20.12893
– volume: 58
  start-page: 143
  year: 2000
  ident: 960_CR97
  publication-title: J Neural Transm Suppl
– volume: 325
  start-page: 201
  year: 2009
  ident: 960_CR26
  publication-title: Science
  doi: 10.1126/science.1173635
– volume: 32
  start-page: 235
  year: 2013
  ident: 960_CR85
  publication-title: Int J Mol Med
  doi: 10.3892/ijmm.2013.1375
– volume: 57
  start-page: 195
  year: 1999
  ident: 960_CR34
  publication-title: J Neurosci Res
  doi: 10.1002/(SICI)1097-4547(19990715)57:2<195::AID-JNR5>3.0.CO;2-P
– volume: 15
  start-page: S28
  issue: Suppl 4
  year: 2009
  ident: 960_CR106
  publication-title: Parkinsonism Relat Disord
  doi: 10.1016/S1353-8020(09)70831-4
– volume: 18
  start-page: 91
  year: 2012
  ident: 960_CR96
  publication-title: Curr Pharm Des
  doi: 10.2174/138161212798918995
– volume: 993
  start-page: 133
  year: 2003
  ident: 960_CR109
  publication-title: Brain Res
  doi: 10.1016/j.brainres.2003.09.004
– volume: 9
  start-page: 91
  year: 2015
  ident: 960_CR8
  publication-title: Front Neuroanat
– volume: 51
  start-page: 313
  year: 2015
  ident: 960_CR48
  publication-title: Mol Neurobiol
  doi: 10.1007/s12035-014-8689-6
– volume: 41
  start-page: 517
  year: 2009
  ident: 960_CR99
  publication-title: J Bioenerg Biomembr
  doi: 10.1007/s10863-009-9250-6
– volume: 44
  start-page: 1787
  year: 2008
  ident: 960_CR29
  publication-title: Free Radic Biol Med
  doi: 10.1016/j.freeradbiomed.2008.03.005
– volume: 52
  start-page: 276
  year: 2002
  ident: 960_CR57
  publication-title: Ann Neurol
  doi: 10.1002/ana.10277
– volume: 45
  start-page: 133
  year: 1995
  ident: 960_CR87
  publication-title: J Neural Transm Suppl
– volume: 1
  start-page: 15
  year: 2010
  ident: 960_CR102
  publication-title: Food Funct
  doi: 10.1039/c0fo00103a
– volume: 28
  start-page: 1081
  year: 2012
  ident: 960_CR117
  publication-title: Nutrition
  doi: 10.1016/j.nut.2012.03.007
– volume: 222
  start-page: 122
  year: 2007
  ident: 960_CR16
  publication-title: Toxicol Appl Pharmacol
  doi: 10.1016/j.taap.2007.02.015
– volume: 443
  start-page: 787
  year: 2006
  ident: 960_CR79
  publication-title: Nature
  doi: 10.1038/nature05292
– volume: 104
  start-page: 8161
  year: 2007
  ident: 960_CR104
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0609874104
– volume: 19
  start-page: 9654
  year: 1999
  ident: 960_CR20
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.19-21-09654.1999
– volume: 33
  start-page: 52
  issue: Suppl 1
  year: 1993
  ident: 960_CR59
  publication-title: Eur Neurol
  doi: 10.1159/000118538
– volume: 30
  start-page: 1166
  year: 2010
  ident: 960_CR88
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.3944-09.2010
– volume: 29
  start-page: 684
  year: 2001
  ident: 960_CR121
  publication-title: Biochem Soc Trans
  doi: 10.1042/bst0290684
– volume: 29
  start-page: 433
  year: 2015
  ident: 960_CR116
  publication-title: CNS Drugs
  doi: 10.1007/s40263-015-0249-8
– volume: 22
  start-page: 1
  year: 2012
  ident: 960_CR69
  publication-title: Neurotox Res
  doi: 10.1007/s12640-011-9295-2
– volume: 44
  start-page: 224
  year: 2008
  ident: 960_CR12
  publication-title: Free Radic Biol Med
  doi: 10.1016/j.freeradbiomed.2007.08.015
– volume: 85
  start-page: 299
  year: 2003
  ident: 960_CR25
  publication-title: J Neurochem
  doi: 10.1046/j.1471-4159.2003.01657.x
– volume: 1
  start-page: 152
  year: 2009
  ident: 960_CR32
  publication-title: EMBO Mol Med
  doi: 10.1002/emmm.200900024
– volume: 38
  start-page: 201
  year: 2013
  ident: 960_CR80
  publication-title: Neurochem Res
  doi: 10.1007/s11064-012-0909-8
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Snippet Parkinson’s disease (PD) is the second most common progressive neurodegenerative disease after Alzheimer’s disease. PD exhibits clinical symptoms that include...
Parkinson's disease (PD) is the second most common progressive neurodegenerative disease after Alzheimer's disease. PD exhibits clinical symptoms that include...
Parkinson’s disease (PD) is the second mostcommon progressive neurodegenerative disease after Alzheimer’sdisease. PD exhibits clinical symptoms thatinclude...
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SubjectTerms agonists
Alzheimer disease
Cytokines - metabolism
dopamine
Dopaminergic Neurons - drug effects
Dopaminergic Neurons - immunology
drugs
etiology
Humans
Inflammation
L-dopa
Medicine
Membrane Potential, Mitochondrial - drug effects
Microglia - drug effects
Microglia - immunology
mitochondria
Neuroprotective Agents - therapeutic use
oxidative stress
Oxidative Stress - drug effects
Parkinson disease
Parkinson Disease - drug therapy
Parkinson Disease - etiology
Parkinson Disease - immunology
Pharmacology/Toxicology
Pharmacy
Plant Preparations - therapeutic use
Review
약학
Title Neuroprotective strategies to prevent and treat Parkinson’s disease based on its pathophysiological mechanism
URI https://link.springer.com/article/10.1007/s12272-017-0960-8
https://www.ncbi.nlm.nih.gov/pubmed/28952032
https://www.proquest.com/docview/1943641311
https://www.proquest.com/docview/2000573850
https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002274726
Volume 40
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