IL-12, but Not IL-18, Is Critical to Neutrophil Activation and Resistance to Polymicrobial Sepsis Induced by Cecal Ligation and Puncture

• Published in: Journal of Immunology Vol. 177; no. 5; pp. 3218 - 3224
• Main Authors: Moreno, Susana E, Alves-Filho, Jose C, Alfaya, Thais M, da Silva, Joao S, Ferreira, Sergio H, Liew, Foo Y
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 01.09.2006
• Subjects: Animals; Cecum - immunology; Cecum - metabolism; Cecum - microbiology; Cecum - surgery; Cell Movement; Interferon-gamma - biosynthesis; Interleukin-12 - deficiency; Interleukin-12 - genetics; Interleukin-12 - metabolism; Interleukin-12 Subunit p40; Interleukin-18 - deficiency; Interleukin-18 - genetics; Interleukin-18 - metabolism; Ligation; Mice; Mice, Knockout; Neutrophil Activation - immunology; Neutrophils - cytology; Neutrophils - immunology; Neutrophils - metabolism; Nitric Oxide - biosynthesis; Phagocytosis; Protein Subunits - deficiency; Protein Subunits - genetics; Protein Subunits - metabolism; Punctures; Sepsis - immunology; Sepsis - metabolism; Sepsis - microbiology; Sepsis - prevention & control; Survival Rate

Sepsis is a systemic inflammatory response resulting from local infection due, at least in part, to impaired neutrophil migration. IL-12 and IL-18 play an important role in neutrophil migration. We have investigated the mechanism and relative role of IL-12 and IL-18 in polymicrobial sepsis induced b...