Activin receptor inhibition by Smad2 regulates Drosophila wing disc patterning through BMP-response elements

• Published in: Development (Cambridge) Vol. 140; no. 3; pp. 649 - 659
• Main Authors: Peterson, Aidan J., O'Connor, Michael B.
• Format: Journal Article
• Language: English
• Published: England Company of Biologists 01.02.2013
• Subjects: Activin Receptors - genetics; Activin Receptors - metabolism; Alleles; Animals; Body Patterning; Bone Morphogenetic Proteins - metabolism; Cell Proliferation; Cell Size; Crosses, Genetic; Drosophila; Drosophila - genetics; Drosophila - metabolism; Drosophila - physiology; Drosophila Proteins - genetics; Drosophila Proteins - metabolism; Epistasis, Genetic; Extracellular Matrix Proteins - genetics; Extracellular Matrix Proteins - metabolism; Female; Gene Expression Regulation, Developmental; Imaginal Discs - metabolism; Imaginal Discs - physiology; Immunohistochemistry; Male; Mutagenesis, Site-Directed; Mutation; Organ Size; Papio; Phenotype; Receptors, Transforming Growth Factor beta - genetics; Receptors, Transforming Growth Factor beta - metabolism; Repressor Proteins - genetics; Repressor Proteins - metabolism; RNA Interference; Signal Transduction; Smad2 Protein - genetics; Smad2 Protein - metabolism; Time Factors; Wings, Animal - metabolism; Wings, Animal - physiology
• ISSN: 0950-1991; 1477-9129; 1477-9129
• DOI: 10.1242/dev.085605

Imaginal disc development in Drosophila requires coordinated cellular proliferation and tissue patterning. In our studies of TGFβ superfamily signaling components, we found that a protein null mutation of Smad2, the only Activin subfamily R-Smad in the fruit fly, produces overgrown wing discs that r...